Results 51 to 60 of about 113,265 (275)

Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation

Scientific Reports, 2017
MicroRNA (miR)-132 brain-to-body messages suppress inflammation by targeting acetylcholinesterase (AChE), but the target specificity of 3’-AChE splice variants and the signaling pathways involved remain unknown.

semanticscholar   +1 more source

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

The Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna, Donald B. Hoover, Logan G. Kirkland, Elizabeth H. Smith, Megan D. Poston, Stanley G. Peirce, Chloe G. Garbe, Steven Cha, Shumpei Mori, Jaclyn A. Brennan, John Andrew Armour, Eric Rytkin, Igor R. Efimov, Olujimi A. Ajijola, Jeffrey L. Ardell, Kalyanam Shivkumar   +15 more
wiley   +1 more source

El genocidio aché: de la protección internacional a la jurisdicción universal

Revista de Estudios sobre Genocidio, 2020
El genocidio aché es un caso paradigmático de exterminio de un pueblo indígena americano en el marco de procesos de colonización del siglo XX. Su tratamiento en el marco de los sistemas internacionales de protección de derechos humanos y en las medidas ...
Hugo Valiente
doaj  

A randomized, double‐blind, placebo‐controlled trial of abatacept for the treatment of relapsing, non‐severe, granulomatosis with polyangiitis

Arthritis &Rheumatology, Accepted Article.
Objective To compare the efficacy of abatacept to placebo for the treatment of relapsing, non‐severe granulomatosis with polyangiitis (GPA). Methods In this multicenter trial, eligible patients with relapsing, non‐severe GPA were randomized to receive abatacept 125 mg subcutaneously once a week or placebo, both together with prednisone 30 mg/day (or ...
Carol A. Langford, Nader Khalidi, Jason Springer, Marcia Friedman, Bernhard Hellmich, Christian Pagnoux, Natasha Dehghan, Ora Gewurz‐Singer, Curry L Koening, Yih Chang Lin, Paul A. Monach, Larry W. Moreland, Aurore Fifi‐Mah, Oliver Flossmann, Lindsy J. Forbess, Peter Lanyon, Eamonn Molloy, Ulrich Specks, Robert Spiera, Elaine Yacyshyn, Carol A. McAlear, Cristina Burroughs, Rachel B. Jones, Rennie L. Rhee, Rula Hajj‐Ali, Kenneth J. Warrington, David Cuthbertson, Jeffrey P. Krischer, David Jayne, Peter A. Merkel, for the Vasculitis Clinical Research Consortium and the European Vasculitis Society   +30 more
wiley   +1 more source

Estrés en profesores de enseñanza secundaria: un análisis desde el optimismo

European Journal of Investigation in Health, Psychology and Education, 2012
En los últimos años parece existir un notable consenso acerca de la importancia de las conductas y/o actitudes problemáticas de los alumnos, las situaciones conflictivas y la ausencia de apoyo social como factores que dificultan la convivencia escolar y ...
Estíbaliz Villardefrancos Pol, María José Santiago Mariño, Cristina Castro Bolaño, Sofía Aché Reinoso, José Manuel Otero-López   +4 more
doaj   +1 more source

Integrative Characterization of Toxic Response of Zebra Fish (Danio rerio) to Deltamethrin Based on AChE Activity and Behavior Strength

BioMed Research International, 2016
In order to characterize the toxic response of zebra fish (Danio rerio) to Deltamethrin (DM), behavior strength (BS) and muscle AChE activity of zebra fish were investigated.
Qing Ren, Tingting Zhang, Shangge Li, Zongming Ren, Meiyi Yang, H. Pan, Shiguo Xu, L. Qi, T. Chon   +8 more
semanticscholar   +1 more source

Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk, Neslihan Balci, Osman Nuri Aslan, Erbay Kalay   +3 more
wiley   +1 more source

The Role of AChE in Swimming Behavior of Daphnia magna: Correlation Analysis of Both Parameters Affected by Deltamethrin and Methomyl Exposure

Journal of Toxicology, 2017
The unpredictable toxicity of insecticides may cause behavior disorder of biological organisms. In order to assess the role of acetylcholinesterase (AChE) in swimming behavior of Daphnia magna, a correlation analysis of both parameters in 24 h exposure ...
Qing Ren, Ruibin Zhao, Cheng Wang, Shangge Li, Tingting Zhang, Zongming Ren, Meiyi Yang, H. Pan, Shiguo Xu, Jianping Zhu, Xun Wang   +10 more
semanticscholar   +1 more source

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen, Oguz Özbek, Meryem Topal, Hatice Şahin, Ümit M. Koçyiğit   +4 more
wiley   +1 more source

Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.

ACS Chemical Neuroscience, 2016
Sunitinib, a tyrosine kinase inhibitor, is clinically used for the treatment of cancer. In this study, we found for the first time that sunitinib inhibits acetylcholinesterase (AChE) at submicromolar concentrations in vitro.
Ling Huang, Jiajia Lin, Siying Xiang, Kan Zhao, Jie Yu, Jiachen Zheng, Daping Xu, Shinghung Mak, Sheng-quan Hu, Shehani Nirasha, Chuang Wang, Xiaowei Chen, Junfang Zhang, Shujun Xu, Xiaofei Wei, Zaijun Zhang, Dongsheng Zhou, Wenhua Zhou, W. Cui, Yifan Han, Zhenyu Hu, Qinwen Wang   +21 more
semanticscholar   +1 more source