Results 81 to 90 of about 64,209 (243)

OS NOVOS RUMOS DA ESTRATÉGIA DE MARKETING NO MERCADO FARMACÊUTICO [PDF]

The pharmaceutical industry invests its sales force in contacts with doctors, making visits and publicizing its drugs, in order for them to prescribe these products to their patients. This work discusses the structure of the pharmaceutical market and how
Correa, Gisleine Fregoneze, Oliveira, Luciel Henrique de   +1 more
core   +1 more source

Brasil: La política pública de producción, distribución y venta de los medicamentos genéricos. [PDF]

, 2013
Resumen:Una política de salud signi ca todo el proceso elaborado por los agentes gubernamentales, civiles y la comunidad participativa de una sociedad para el progreso de una buena calidad de salud a todos los ciudadanos.
Moreira Saboya, Ricardina María Batista, Ruano Casado, Luisa   +1 more
core   +1 more source

Synthesized flavone attenuates diabetes‐induced neurodegeneration through regulation of oxidative stress and metabolic‐neurodegenerative molecular pathways

Ibrain, EarlyView.
Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen, Anita Sakarwal, Heera Ram, Suman K. Saha, Nirmal K. Rana, Dharmveer Yadav, Sunil Dutt Shukla, Mukesh Kumar Yadav, Balachandar Vellingiri, Vikas Kumar   +9 more
wiley   +1 more source

Model acetylcholinesterase‐Fc fusion glycoprotein biotechnology system for the manufacture of an organophosphorus toxicant bioscavenging countermeasure

Bioengineering & Translational Medicine
Organophosphate (OP) toxicants remain an active threat to public health and to warfighters in the military. Current countermeasures require near immediate administration following OP exposure and are reported to have controversial efficacies ...
Thomas G. Biel, Talia Faison, Alicia M. Matthews, Uriel Ortega‐Rodriguez, Vincent M. Falkowski, Edward Meek, Xin Bush, Matthew Flores, Sarah Johnson, Wells W. Wu, Mari Lehtimaki, Rong‐Fong Shen, Cyrus Agarabi, V. Ashutosh Rao, Janice E. Chambers, Tongzhong Ju   +15 more
doaj   +1 more source

Inhibition of Muscle-Specific Protein Kinase (MuSK) Releases Organophosphate-Aged Acetylcholinesterase (AChE) from C2C12 Cells

Toxics
Mechanistically, OPs inhibit acetylcholinesterase (AChE), an enzyme that terminates cholinergic transmission, triggering a sustained activation of acetylcholine receptors.
Monica Moncada-Restrepo, Sarah Eysoldt, Jeronimo Medina, Valentina Di Guida, Jeremy W. Chambers   +4 more
doaj   +1 more source

Differential Inhibition of the Brain Acetylcholinesterase Molecular Forms Following Sarin, Soman and VX Intoxication in Laboratory Rats

Acta Medica, 1997
The female Wistar rats were intoxicated (i.m.) with sarin, soman and VX in doses equal to 1xLD50 and pontomedullar areas of the brain were prepared, homogenized, centrifuged and in these samples, acetylcholinesterase (AChE, EC 3.1.1.7) activities were ...
Jiří Bajgar
doaj   +1 more source

Pelvic venous disorders in women: Diagnosis and management for gynecologists

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive‐aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview of PeVD for gynecologists, outlining its pathophysiology, common presentations, diagnostic approach, and ...
Tiffany Ni, Inbar Friedman, Jessica Smith, Brian Liu, Mary Melchior, Andrew D. Brown   +5 more
wiley   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Developmental dynamics of symptoms of emotional problems in childhood and adolescence: A longitudinal network analysis

JCPP Advances, EarlyView.
This study examined how emotional symptoms co‐develop from childhood to adolescence using longitudinal data from over 11,000 children and adolescents. Network analyses revealed reciprocal links between core symptoms of anxiety and depression, with no significant differences between males and females.
Eira R. Aksnes, Marianne Skogbrott Birkeland, Omid V. Ebrahimi, Mona Bekkhus, Lia Ferschmann, Dani Beck, Trude Fixdal, Alexandra Havdahl, Lydia Gabriela Speyer, Lars T. Westlye, Marieke G. N. Bos, Christian K. Tamnes   +11 more
wiley   +1 more source

Cholinesterase-targeting microRNAs identified in silico affect specific biological processes

Frontiers in Molecular Neuroscience, 2011
MicroRNAs (miRs) have emerged as important gene silencers affecting many target mRNAs. Here, we report the identification of 244 miRs that target the 3'-untranslated regions of different cholinesterase transcripts: 116 for butyrylcholinesterase (BChE ...
Geula eHanin, Hermona eSoreq
doaj   +1 more source