Results 91 to 100 of about 1,085,498 (298)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

‘We were there too’: There is much to learn from embedding auto/biography in the knowing and doing of prison research

Methodological Innovations, 2017
Within the social sciences, there is a wealth of literature that examines the challenges and ethical dilemmas encountered by researchers in conceptualising, conducting and understanding their research.
Geraldine Brown, Elizabeth Bos
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Nominations for Hamming Faculty Award for Interdisciplinary Achievement, 2000 [PDF]

, 2000
Hamming Interdisciplinary Achievement Award Recognition ...
Hamming Interdisciplinary Achievement Award Selection Committee
core   +1 more source

Reliable and Cost-Effective QuEChERS–UHPLC–MS/MS Method for the Simultaneous Analysis of Ten Mycotoxins in Dendrobium Officinale: A Study on Food-Medicine Homology Quality Control

Journal of Analytical Methods in Chemistry
This study developed a method for simultaneously detecting 10 mycotoxins in Dendrobium officinale using the QuEChERS technique combined with ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). The method was optimized for
Zejun Wang, Qingcheng Wang, Fei Xu, Linhua Wang, Jingjing Liang, Qing Shen, Shunyuan Guo   +6 more
doaj   +1 more source

Unraveling HIV-1 spread in Southwest China: a phylogenetic and molecular network approach

Frontiers in Microbiology
Guangxi is one of the regions most affected by HIV-1 in China, yet the fine-scale transmission dynamics and molecular epidemiology remain incompletely characterized.
Xianwu Pang, Kailing Tang, Qin He, Jie Ma, Ningye Fang, Haomin Xie, Ge Zhong, Shujia Liang   +7 more
doaj   +1 more source

Teacher certification and student achievement in Swedish compulsory schools [PDF]

This study examines how the teaching staff composition with respect to certification affects student achievement in compulsory Swedish schools. The share of non-certified teachers in compulsory schooling has increased dramatically during the last decade,
Waldenström, Nina, Andersson, Christian
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An exploration of Turkish EFL pre-service Teachers' perceptions on the integration of generative AI in English language Teacher Education: benefits, challenges, and future directions

Asian-Pacific Journal of Second and Foreign Language Education
This study explores the perceptions of pre-service English as a Foreign Language (EFL) teachers in Türkiye regarding the integration of generative artificial intelligence (GenAI) into English language teacher education.
Meltem Eşki, Nurullah Eryılmaz
doaj   +1 more source