Results 91 to 100 of about 771,630 (262)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Effects of Performance-Based Teacher Pay on Student Achievement [PDF]
I evaluate the effects on student achievement of the Teacher AdvancementProgram (TAP), a school-level intervention that offers teachers professional development resources and performance-based compensation.
Sally Hudson
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Students’ perceptions of eMarking: Grademark vs. iAnnotate.
, 2015 Feedback on assessments is central to formative learning in higher education; it is also a main cause of dissatisfaction in student surveys. New advances in e-learning and eMarking have the potential to improve teaching and learning in this area. In this
Olson, Rebecca +3 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
[News Clip: Junior achievement]
, 1958 Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about a Fort Worth high school senior Ronnie Zodin receiving an award in New York for being a part of one of the United States' five junior achievement ...
WBAP-TV (Television station : Fort Worth, Tex.)
core +1 more source
Schools and student achievement: more evidence from the Milwaukee parental choice program [PDF]
Using math and reading test score gains, the author compares the achievement of students in the nonsectarian private schools participating in Milwaukee's Parental Choice Program with the achievement of students in a wide range of Milwaukee's public ...
Cecilia Elena Rouse
core
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source