Results 81 to 90 of about 1,378,466 (344)

Optimization of Humanistic Education in the Integrated Islamic Primary School

open access: yesAl Ibtida: Jurnal Pendidikan Guru MI, 2019
Only a few primary schools apply humanistic education. This could be viewed from the students’ moral decadence and the process of dehumanizing education.
Asep Kurniawan
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Evaluating German PISA stratification designs: a simulation study

open access: yesLarge-scale Assessments in Education
Stratification is an important design feature of many studies using complex sampling designs and it is often used in large-scale assessment (LSA) studies, such as the Programme for International Student Assessment (PISA), for two main reasons.
Julia Mang   +2 more
doaj   +1 more source

The Social Validity of Video Modeling Versus Virtual Reality for Improving the Social Communication Skills of Middle School Students

open access: yesIssues and Trends in Learning Technologies
The extent to which an intervention is perceived as sociallyvalid significantly influences whether the intervention is selected,implemented, and maintained (Kern & Manz, 2004).
Adam C Carreon   +9 more
doaj   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Undergraduate Achievement Disparities between Demographic Subgroups in English Universities

open access: yesTrends in Higher Education
In this paper, we report a comprehensive analysis of the disparities in undergraduate degree achievements across different demographic groups in English universities.
Pallavi Banerjee, Nurullah Eryilmaz
doaj   +1 more source

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