Results 11 to 20 of about 7,395 (191)

Evaluation of Aciclovir-Induced Nephrotoxicity in Critically Ill Patients: A Propensity-Matched Cohort Study. [PDF]

J Clin Med
Background/Objectives: Aciclovir is a widely used antiviral agent. Since aciclovir is primarily eliminated through the kidneys, maintaining renal function is crucial to avoid toxicity. Although mitigating strategies are introduced in the standard of care,
Boosman RJ, Bosman RJ, van der Voort PHJ, Franssen EJF.   +3 more
europepmc   +4 more sources

A UHPLC–MS/MS Method for Therapeutic Drug Monitoring of Aciclovir and Ganciclovir in Plasma and Dried Plasma Spots

Biomedicines, 2021
The role of therapeutic drug monitoring (TDM) of valaciclovir (VA)/aciclovir (A) and valganciclovir/ganciclovir (VG/G) in critically ill patients is still a matter of debate.
Federica Pigliasco, Alessia Cafaro, Raffaele Simeoli, Sebastiano Barco, Alberto Magnasco, Maura Faraci, Gino Tripodi, Bianca Maria Goffredo, Giuliana Cangemi   +8 more
doaj   +2 more sources

Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial

BMJ Open, 2019
Objective To compare New Zealand medical grade kanuka honey with topical aciclovir for the treatment of herpes simplex labialis.Design Prospective parallel randomised controlled open-label superiority trial.Setting 76 community pharmacies across New ...
Nick Shortt, Alex Semprini, Mark Weatherall, Richard Beasley, Irene Braithwaite, Angela Liu, Melanie McConnell, Joseph Singer, Darmiga Thayabaran, Abbie Copinga, Abigail Cadwallader, Ahmad Zareh, Aidan Kortegast, Al-Sheibani Saif, Alaina van Zyl, Alex Graham, Alice Liu, Alice Manch, Alison van Wyke, Amanda Barkley, Amy Zhuang, Andrew Mcglashen, Androulla Kotrotsos, Angela Blackwood, Angeline Day-Mesuré, Annabel Turley, Anne Lim, Anne Marie-Nimmo, Anstey Harsant, Anthony Roberts, Ashley Cronin, Barbara Mcrae, Blair Finlayson, Bob Kim, Brandon, Brendon Mcintosh, Brian Johnston, Carina Soeteman, Carla Mcinness, Carrol Newman, Cassie Butler, Catherine Hosler, Cathy Hight, Chantel Kissick, Charlotte Schimanski, Chau Ly, Cheryl Mabbett, Chris Wrapson, Christy Biju, Chuck Varghese, Claire Livingston, Corry Bezems, Danielle Stewart, Daryl Sayer, David Postlewaight, Deb Lawrence, Debora Ngny, Deborah Ellison, Debra Clutterback, Delphine Destrez, Diana Montelli, Dipika Parmar, Dixie Howard, Donnie Loh, Eddie See, Elda Lubbe, Eric Li, Evan Tan, Fiona Mclachlan, Fiona Srush, Fran Chen, Garth Mitchinson, Gina Azer-Iskander, Glenn Summerville, Grace O’conner, Grant Bell, Hayley Garvin, Helen Jarvie, Henriette Meyer, Ingrid Nickson, Ingrid Reed, Irene Nicks, Jackie Jamieson, Jacqui Brus, Jacqui Craw, James Westbury, Jan Green, Janet Downing, Jayne Lewis, Jenna Ludlow, Jenni Puckley, Jennifer Gerbes, Jenny Sparks, Jenny Wu, Jess Barton, Jessica Ensor, Jilly Alexander, Jim Sherborne, Joanna Topliss, Jordan Jeffray, Jordon Hinton, Joseph Tsou, Joy Birch, Julia Mcdonald, Julie Earwaker, Julie Lamb, Julie Summers, Kadyn Lowe, Kaleigh Mackel, Karen Rich, Karen Chen, Karen Wainman, Karena Hall, Kate Adams, Kate Griffin, Kayleigh Mackel, Kelly Burgess, Kelly Harvey, Kelly Shearer, Kelsi Burns, Kerry Dean, Kerry Oxenham, Kritika Singh, Lara Blaikie, Leanne Hall, Leanne Herbert, Leanne Hosking, Leanne Steele, Leigh Vaughan, Lesley Robertson, Levi Bian, Linda Herman, Linda Joe, Linda Southby, Lisa Josephs, Lisa Mitchell, Lorina Lu, Lorraine Brunton, Lucy Armstrong, Lynda Bell, Malinda Ouk, Malli Kotali, Marcus Liddle, Margaret Helms, Marion Gray, Mark Arundel, Mark Webster, Martin Boyle, Maryanne Smyth, Mate Hegedus-Gaspar, Matthew Grey, Maureen Raju, Melanie Wong, Michelle Hwang, Michelle Nawisielski, Michelle Speirs, Natascha Roughton, Navjot Kaw, Neha Chand, Nehad Kamel, Neville Puckey, Nicholas Tee, Nimmi Gnanasekaran, Nolan Mcrae, Noor Al-Rawe, Oliver Rew, Olivia Haslam, Outi Kolju, Palak Mehta, Patrick Lim, Peter Neal, Rachael Gerretzen, Rachael Munns, Rachel Yang, Rachelle Smith, Raksha Goundar, Rav Singh, Ravniel Singh, Rebecca Coley, Rebecca Hesom, Rebekah Beard, Reece Olsen, Renee Belling, Robyn Morrison, Roseanna Mcdonald, Ruby Willing, Saif Al-Sherbeni, Sally Purdie, Sam Betty, Sam Appleford, Samantha Fordham, Samit Patel, Sara Preston, Sarah Wallace, Sascha Ion, Shahlaa Al Salih, Sharon Sullivan, Shazeel Rauf, Sheryl Montgomerie, Shilpa Narain, Shirin Namjou, Shuji Zhang, Simerjeet Singh, Sjaani Stanley, Sonia Schwaum, Steve Jo, Sultana Zannat, Tanya Baker, Tyler Pornchaisuksiri, Utsav Sharma, Vicki Douglas, Victoria Rameke, Vincent Ho, Vioky Usher, Violet Harley, Vishwatej Gangapuri, Warren Greene, Wendy Parkes, William Gia, Wilma Gordon, Yalun Weng, Yasmin Razoki, Yolanda Savage, Zheng Li   +223 more
doaj   +2 more sources

Antiviral activity of the organic germanium complex with aciclovir against herpes simplex virus (Herpesviridae: Alphaherpesvirinae: Simplexvirus: Human alphaherpesvirus 1/2) in the in vitro and in vivo systems

Вопросы вирусологии, 2021
Introduction. A significant increase in the incidence of various forms of herpesvirus infection (HVI) determines the need to search for new approaches to the modification of one of the basic antiviral drugs aciclovir (ACV) and its dosage forms to improve
L. M. Alimbarova, I. V. Ambrosov, S. K. Matelo, I. F. Barinsky   +3 more
doaj   +2 more sources

Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV. [PDF]

PLoS ONE, 2017
There is a clinical need for new therapeutic products against Herpes simplex virus (HSV). The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection.
David M J Houston, Joachim J Bugert, Stephen P Denyer, Charles M Heard   +3 more
doaj   +2 more sources

Praxisempfehlungen für die Therapie und Überwachung von Mogamulizumab‐Patienten in Deutschland [PDF]

J Dtsch Dermatol Ges
Zusammenfassung Mycosis fungoides (MF) und Sézary‐Syndrom (SS) sind die häufigsten Subtypen der heterogenen Gruppe der kutanen T‐Zell‐Lymphome (CTCL). Mit der Erweiterung der Therapielandschaft sind in den letzten Jahren neue Behandlungsoptionen verfügbar geworden, allen voran der gegen den C‐C‐Chemokinrezeptor 4 (CCR4) gerichtete monoklonale ...
Assaf C, Booken N, Dippel E, Dobos G, Eich H, Klemke C, Mitteldorf C, Nicolay J, Theurich S, Wobser M, Stadler R.   +10 more
europepmc   +2 more sources

Stewardship: it's going viral [PDF]

Infection Prevention in Practice
Summary: Introduction: Historically, antimicrobial stewardship (AMS) has considered the judicious use of antibiotics. AMS is widely adopted across Europe and the US; recently antifungal AMS is gaining momentum but antiviral AMS has been little described.
Abigail Jenkins, Jubeyr Ahmed, Andrew Bosworth, I Michael Kidd, Husam Osman, Sowsan F. Atabani   +5 more
doaj   +2 more sources

The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial

Neurological Research and Practice, 2019
Introduction Comprehensive treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major clinical challenge. The current therapy gold standard is aciclovir, a drug that inhibits viral replication.
U. Meyding-Lamadé, C. Jacobi, F. Martinez-Torres, T. Lenhard, B. Kress, M. Kieser, C. Klose, K. Einhäupl, J. Bösel, M-B Mackert, V. Homberg, C. Koennecke, G. Weißheit, D. Claus, B. Kieseier, J. Bardutzky, T. Neumann-Haefelin, M. W. Lorenz, H. Steinmetz, C. Gerloff, D. Schneider, A. Grau, M. Klein, R. Dziewas, U. Bogdahn, W. Jakob, R. Linker, K. Fuchs, A. Sander, S. Luntz, T. Hoppe-Tichy, D. F. Hanley, R. von Kummer, E. Craemer   +33 more
doaj   +2 more sources

Acute kidney injury (AKI) associated with intravenous aciclovir in adults: Incidence and risk factors in clinical practice

International Journal of Infectious Diseases, 2018
Objectives: This study sought to identify the incidence of, and risk factors for, acute kidney injury (AKI) in adults treated with parenteral aciclovir.
Lucy Ryan, Andrew Heed, Jonathan Foster, Manoj Valappil, Matthias L. Schmid, Christopher J.A. Duncan   +5 more
doaj   +2 more sources

High-dose aciclovir in CMV infection prophylaxis after allogeneic HSCT: a single-center long-term experience. [PDF]

Bone Marrow Transplant, 2023
There is only limited data on cytomegalovirus (CMV) prophylaxis with high-dose (HD) aciclovir after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Kabut T, Weinbergerová B, Folber F, Lengerová M, Mayer J.   +4 more
europepmc   +2 more sources