Results 41 to 50 of about 7,605,068 (272)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Studying the effect of complex therapy with the application of antigypoxants on some indicators of electrolytic blood composition in borderline dissociative disorders

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2021
Background. The development of new approaches to the therapy of dissociative disorders, taking into account the pathogenetic mechanisms in their formation, is an urgent task of psychopharmacology.
E.V. Govsh, S.V. Kiryukhina, V.G. Podsevatkin, D.A. Labunskiy, V.A. Kolmykov   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mixed acid-base disorders, hydroelectrolyte imbalance and lactate production in hypercapnic respiratory failure: the role of noninvasive ventilation. [PDF]

PLoS ONE, 2012
BACKGROUND: Hypercapnic Chronic Obstructive Pulmonary Disease (COPD) exacerbation in patients with comorbidities and multidrug therapy is complicated by mixed acid-base, hydro-electrolyte and lactate disorders.
Claudio Terzano, Fabio Di Stefano, Vittoria Conti, Marta Di Nicola, Gregorino Paone, Angelo Petroianni, Alberto Ricci   +6 more
doaj   +1 more source

Pharmacotherapy of Acid-Base disturbances

, 2022
Acid-base balance is a complex and delicate system regulated by multiple components that have a critical function in the human body. The balance of acid and bases is a key component in keeping the homeostasis of blood plasma.
Heimisdóttir, Arndís
core  

PATTERN OF ACID BASE ABNORMALITIES IN CRITICALLY ILL PATIENTS

Pakistan Armed Forces Medical Journal, 2015
Objective: To find out the pattern of acid base abnormalities in critically ill patients in a tertiary care health facility. Study Design: A descriptive study.
Tariq Mahmood Ahmad, Aamer Mehmood, Tariq Masood Malik, Muhammad Aamir   +3 more
doaj   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Antacid preparations in the modern treatment of acid-base disorders

Медицинский совет, 2014
Until the middle of the XX century, a large group of drugs called antacids played the key role in the treatment of acid-related diseases. Antacids have long been used to relieve heartburn and pain in the upper gastrointestinal tract.
S. A. Babanov, E. B. Grischenko
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source