Results 31 to 40 of about 2,470 (188)

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis

Advanced Biology, EarlyView.
Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard, Kaja Borup Løvschall, Mireia Casanovas Montasell, Clara Bakkegaard Cramer, Pere Monge Marcet, Andreas Bøtker Pedersen, Josefine Hammer Jakobsen, Alexander N. Zelikin   +7 more
wiley   +1 more source

Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells

Advanced Biology, EarlyView.
TEV Prtoease‐mediated Releasable Actin‐binding Protein (TRAP) is a protein‐based platform consisting of a cargo tightly bound to reconstituted actin networks in synthetic cells which can be proteolyticly released from the bound actin, followed by its secretion through membrane translocation mediated by a cell‐penetrating peptide.
Mousumi Akter, Hossein Moghimianavval, Gary D. Luker, Allen P. Liu   +3 more
wiley   +1 more source

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer‐Lipid Hybrid Vesicles

Advanced Biology, EarlyView.
The successful in situ polymerization of microtubules in giant polymer‐lipid hybrid vesicles is illustrated. The microtubules formed in the giant hybrid vesicles exhibit different morphologies including lumenal network formation and membrane association. Abstract Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a
Paula De Dios Andres, Mousumi Akter, Cecilie Ryberg, Brigitte Städler, Allen P. Liu   +4 more
wiley   +1 more source

Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

Advanced Biology, EarlyView.
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André, Nikita Rehnberg, Ankush Garg, Magnus Kjærgaard   +3 more
wiley   +1 more source

Hydrogel‐Based Capacitive Sensor Model for Ammonium Monitoring in Aquaculture

Advanced Engineering Materials, EarlyView.
Traditional techniques for monitoring aquaculture water quality, particularly ammonium levels, harm fish. This work presents a novel capacitive sensor with an ionic hydrogel transducer to monitor ammonium concentration in real time based on the ammonium‐induced hydrogel dissociation and osmotic pressure. Monitoring aquaculture water quality, especially
Mohammad Mirzaee, Mahdi Askari‐sedeh, Ali Zolfagharian, Mostafa Baghani   +3 more
wiley   +1 more source

THE STABILITY OF THE ACID-BASE EQUILIBRIUM OF THE BLOOD IN NATURALLY NEPHROPATHIC ANIMALS AND THE EFFECT ON RENAL FUNCTION OF CHANGES IN THIS EQUILIBRIUM [PDF]

, 1918
William deB. MacNider
openalex   +1 more source

Impact of Surface Roughness on the Yield Drop of Hot‐Rolled AZX311 Mg Alloy

Advanced Engineering Materials, EarlyView.
Rough‐surfaced AZX311 Mg alloy samples have significantly lower yield strength than polished ones due to stress concentrators forming at V‐notch irregularities. Surface profilometry confirms higher Ra values for rough samples. Highest hardness values were observed near scratched surfaces, indicating strain localization effects near the rough surface ...
Hafiz Muhammad Rehan Tariq, Hyun‐Hak Kang, Umer Masood Chaudry, Muhammad Kashif Khan, Tea‐Sung Jun   +4 more
wiley   +1 more source

Acid-base equilibrium: The best clinical approach☆

Colombian Journal of Anesthesiology, 2015
Acid-base balance disorders can be found in a primary or secondary form in patients with a disease process such as Diabetes Mellitus or acute renal failure, among others. The objective of this article is to explain and guide the correlation ship between the clinical findings in the patient and the parameters of arterial blood gases in a simple and ...
Aristizábal-Salazar, Raúl E, Calvo-Torres, L. Felipe, Valencia-Arango, Luis Alfonso, Montoya-Canon, Mauricio, Barbosa-Gantiva, Oscar, Hincapié-Baena, Vanessa   +5 more
openaire   +3 more sources

Revealing the γ′ and γ″ Phase Fractions of Additively Manufactured and Differently Heat‐Treated Nickel‐Base Superalloy IN718 by Atom Probe Tomography and Their Impact on Mechanical Properties

Advanced Engineering Materials, EarlyView.
Additive manufacturing is a promising route for the production of Ni‐base superalloys for turbine applications, such as Inconel 718. Nonetheless, it induces various changes in the microstructure and performance of these materials. One such change is the incidence of the δ‐Ni3Nb phase, whose impact on microstructure, aging precipitate fractions, and ...
Guilherme Maziero Volpato, Jan Vollhüter, Benedikt Diepold, Martin Sebastian Meier, Martin Pröbstle, Mathias Göken, Thomas Niendorf, Peter Felfer, Steffen Neumeier   +8 more
wiley   +1 more source