Results 31 to 40 of about 59,217 (252)

The Domino Effect: Hyperventilation, Hypocapnia, and Tetany in Airway Management [PDF]

open access: yesJournal of Clinical and Diagnostic Research
Airway management represents one of the most critical challenges in anaesthesiology, particularly in patients with history of head and neck surgeries due to altered anatomy.
Subha Teresa Jose Vazhakalayil   +3 more
doaj   +1 more source

Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota

open access: yesFrontiers in Medicine, 2022
The incidence and mortality of colorectal cancer (CRC) have been markedly increasing worldwide, causing a tremendous burden to the healthcare system. Therefore, it is crucial to investigate the risk factors and pathogenesis of CRC.
Xi Jiang   +5 more
doaj   +1 more source

Hyperchloremic metabolic acidosis during bipolar transurethral resection of the prostate: a report of two cases

open access: yesJournal of International Medical Research, 2021
Compared with monopolar transurethral resection of the prostate (TURP), which requires electrolyte-free irrigation fluid, normal saline can be used as the irrigation solution in bipolar and laser TURP.
Ann Hee You   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Study on the content of nurses' right to prescribe medicines for correcting water, electrolytes, acid⁃base disorders, blood volume expansion medicines and nutrition medicines

open access: yesHuli yanjiu, 2020
ObjectiveTo probe into the contents and forms of prescription right of drugs that correcting imbalance of water,electrolyte and acid⁃base,dilatating blood volume and providing nutrition,and prescirbed by general surgical nurses who met applicant ...
JIA Xiaoyue   +6 more
doaj  

Correlation of base deficit and age shock index with in-hospital mortality in geriatric major trauma patients: a 1-year retrospective study at a single level I trauma center in Indonesia [PDF]

open access: yesJournal of Trauma and Injury
Purpose Base deficit (BD) and age shock index have been utilized as an indicator of resuscitation adequacy and a predictor of poor outcomes in trauma cases, respectively.
Miftahul Khairat Musmar Elbama   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Tubular Handling of Uric Acid and Factors Influencing Its Renal Excretion: A Short Review [PDF]

open access: yesEuropean Medical Journal Nephrology, 2016
In this review, the authors briefly examine the most recent evidence concerning the role of several proteins involved in tubular urate transport. They also analyse the influence of extracellular volume, electrolyte disorders, acid-base imbalance, and ...
Tubular Handling of Uric Acid and Factors Influencing Its Renal Excretion: A Short Review   +4 more
doaj  

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