Results 51 to 60 of about 155,407 (333)

Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota

Frontiers in Medicine, 2022
The incidence and mortality of colorectal cancer (CRC) have been markedly increasing worldwide, causing a tremendous burden to the healthcare system. Therefore, it is crucial to investigate the risk factors and pathogenesis of CRC.
Xi Jiang, Zhongxiu Jiang, Qi Cheng, Wei Sun, Min Jiang, Yan Sun   +5 more
doaj   +1 more source

Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism [PDF]

, 2010
Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing α4 and β2 subunits (α4β2*) functionally interact with G-protein-coupled dopamine (DA) D_2 receptors in basal ganglia.
Andrew R. Tapper, Bruce N. Cohen, Coward D. M., Franklin K. B. J., Henry A. Lester, Herwig Just, Janssen P. A., Lester H. A., Mercuri N. B., Outi Salminen, Paul D. Gardner, Paul Whiteaker, Raz A., Rubing Zhao-Shea, Salminen O., Sharon R. Grady, Sotnikova T. D., Tapper A. R., Tristan McClure-Begley   +18 more
core   +3 more sources

Acid-Base and Electrolytes Profile in Critically Ill Pediatric Patients Admitted to Pediatric Intensive Care Unit (PICU)

Majalah Kedokteran Bandung
Critically ill pediatric patients are known to experience more frequent episodes of acid-base and electrolyte imbalances when compared to adults, which can significantly impact morbidity and mortality with higher mortality rates and longer hospital stays.
Alya Roosrahima Khairunnisa, Stanza Uga Peryoga, Ahmedz Widiasta   +2 more
doaj   +1 more source

Hyperchloremic metabolic acidosis during bipolar transurethral resection of the prostate: a report of two cases

Journal of International Medical Research, 2021
Compared with monopolar transurethral resection of the prostate (TURP), which requires electrolyte-free irrigation fluid, normal saline can be used as the irrigation solution in bipolar and laser TURP.
Ann Hee You, Ji Yoo Lee, Jeong-Hyun Choi, Mi Kyeong Kim   +3 more
doaj   +1 more source

Machine Learning and Integrative Analysis of Biomedical Big Data. [PDF]

, 2019
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome)
Choi, Howard, Chung, Neo Christopher, Mirza, Bilal, Ping, Peipei, Wang, Jie, Wang, Wei   +5 more
core   +1 more source

Pore-blockade Times for Field-Driven Polymer Translocation [PDF]

, 2008
We study pore blockade times for a translocating polymer of length $N$, driven by a field $E$ across the pore in three dimensions. The polymer performs Rouse dynamics, i.e., we consider polymer dynamics in the absence of hydrodynamical interactions.
Akeson M, de Gennes P-G, Debabrata Panja, Dreiseikelmann B, Dubbeldam J L A, Gerard T Barkema, Henk Vocks, Metzler R, Nakane J J, Panja D, Panja D, Panja D, Panja D Barkema G T, Panja D Barkema G T Ball R C, Panja D Barkema G T Ball R C, Robin C Ball, Szabò I   +16 more
core   +2 more sources

The Domino Effect: Hyperventilation, Hypocapnia, and Tetany in Airway Management [PDF]

Journal of Clinical and Diagnostic Research
Airway management represents one of the most critical challenges in anaesthesiology, particularly in patients with history of head and neck surgeries due to altered anatomy.
Subha Teresa Jose Vazhakalayil, Sandeep Veer, Brinda Badam, Jayant Mane   +3 more
doaj   +1 more source

Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans [PDF]

, 2019
Mutations in pre-synaptic voltage gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or reduced inhibition, the molecular ...
Alkema, Mark J., Francis, Michael M., Gao, Shangbang, Grant, Jeff, Huang, Yung Chi, Mulcahy, Ben, Pirri, Jennifer K., Rayes, Diego Hernán, Saheki, Yasunori, Zhen, Mei   +9 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Correlation of base deficit and age shock index with in-hospital mortality in geriatric major trauma patients: a 1-year retrospective study at a single level I trauma center in Indonesia [PDF]

Journal of Trauma and Injury
Purpose Base deficit (BD) and age shock index have been utilized as an indicator of resuscitation adequacy and a predictor of poor outcomes in trauma cases, respectively.
Miftahul Khairat Musmar Elbama, M. Iqbal Rivai, Irwan, Avit Suchitra, Aulia Rahman, Rose Dinda Martini   +5 more
doaj   +1 more source