Results 61 to 70 of about 155,407 (333)

Acid-base abnormalities and liver dysfunction

Annals of Hepatology, 2022
In addition to the kidneys and lungs, the liver also plays an important role in the regulation of the Acid-Base Equilibrium (ABE). The involvement of the liver in the regulation of ABE is crucial because of its role in lactic acid metabolism, urea ...
Periklis Katopodis, Efthymios M. Pappas, Konstantinos P. Katopodis   +2 more
doaj   +1 more source

Effects of low seawater pH on the marine polychaete Platynereis dumerilii [PDF]

, 2015
An important priority for any organism is to maintain internal cellular homeostasis including acidbase balance. Yet, the molecular level impacts of changing environmental conditions, such as low pH, remain uncharacterised.
Arendt, Detlev, Chapman, Emma C., Hardege, Joerg D., Hardege, Jörg D., Larsson, Tomas A., Rotchell, Jeanette M., Simakov, Oleg, Waege, Janine, Wäge, Janine   +8 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Study on the content of nurses' right to prescribe medicines for correcting water, electrolytes, acid⁃base disorders, blood volume expansion medicines and nutrition medicines

Huli yanjiu, 2020
ObjectiveTo probe into the contents and forms of prescription right of drugs that correcting imbalance of water,electrolyte and acid⁃base,dilatating blood volume and providing nutrition,and prescirbed by general surgical nurses who met applicant ...
JIA Xiaoyue, HAN Shifan, ZHU Ruifang, CAO Yan, MENG Yifei, XU Zhuya, WANG Yaping   +6 more
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. [PDF]

, 2019
One fundamental but understudied mechanism of gene regulation in disease is allele-specific expression (ASE), the preferential expression of one allele.
A Chess, A de la Chapelle, A Gimelbrant, A Hogart, A McKenna, A Mortazavi, AA Adegbola, AL Oberg, AM Veerappa, B DeVeale, B Howie, B Langmead, B Tycko, C Fuchsberger, C Gicquel, C Gregg, C Lee, CA de Leeuw, CCY Wong, Changhoon Lee, Cross-Disorder Group of the Psychiatric Genomics Consortium., D Kim, Daniel H. Geschwind, DH Geschwind, E Ben-David, E Eden, E Eden, E Gardiner, EH Cook Jr., Eleazar Eskin, EM Quinn, Eun Yong Kang, EY Kang, F Supek, GT Consortium, GV Kryukov, H Li, HA Scoles, I Iossifov, I Voineagu, J Cavaille, J Cavaille, J Grove, JC Darnell, JF Degner, JK Pickrell, KR Kukurba, M Elsabbagh, M Meguro-Horike, Michael J. Gandal, N Mukherjee, NN Parikshak, NN Parikshak, PH Sudmant, PS Bazeley, R Karlic, S Anders, S Kehr, S Kishore, S Nardone, S Purcell, Schizophrenia Working Group of the Psychiatric Genomics Consortium., SE Castel, SJ Sanders, SM Weyn-Vanhentenryck, T Hulsen, V Savova, Y Zhang, YE Wu   +68 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Tubular Handling of Uric Acid and Factors Influencing Its Renal Excretion: A Short Review [PDF]

European Medical Journal Nephrology, 2016
In this review, the authors briefly examine the most recent evidence concerning the role of several proteins involved in tubular urate transport. They also analyse the influence of extracellular volume, electrolyte disorders, acid-base imbalance, and ...
Tubular Handling of Uric Acid and Factors Influencing Its Renal Excretion: A Short Review, Gabriele Pricoco, Damiano Cantone, Elisa Marino, Francesca Bruno   +4 more
doaj  

Use of intravenous sodium bicarbonate in neonatal intensive care units in Italy: a nationwide survey

Italian Journal of Pediatrics, 2021
Background Metabolic Acidosis (MA) is a disturbance of the acid-base balance that can occur in preterm and critically ill term neonates due to different etiologies. Intravenous sodium bicarbonate (SB) has been traditionally used to correct such unbalance,
Luca Massenzi, Roberto Aufieri, Silvia Donno, Rocco Agostino, Andrea Dotta, on behalf of the Neonatal Pharmacotherapy Study Group of the Italian Society of Neonatology (SIN)   +5 more
doaj   +1 more source

A Rare Case Received A Late Diagnosis Despite Recurrent Hospital Admissions: Infantile Hypertrophic Pyloric Stenosis

Çocuk Dergisi, 2021
Infantile hypertrophic pyloric stenosis is the narrowing of the pyloric duct due to hypertrophy of the pylorus. The disease manifests itself with gushing and non-bile vomiting in babies after feeding.
Cüneyt Uğur, Enes Ay, Hasan Madenci
doaj   +1 more source