Results 61 to 70 of about 59,884 (251)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Perioperative care in pediatric OTC deficiency and goldenhar syndrome: a case report

Frontiers in Pediatrics
Ornithine transcarbamylase deficiency (OTCD) is an X-linked disorder disrupting the urea cycle in 1 per 56,000 births. Goldenhar syndrome (GS), characterized by craniofacial and vertebral anomalies, is seen in 1 per 3,000–5,000 births.
Daniela Torres Salazar, Daniela Torres Salazar, Andres Felipe Beltran, Andres Felipe Beltran, Sergio Alzate-Ricaurte, Sergio Alzate-Ricaurte   +5 more
doaj   +1 more source

Study on biochemical findings and status of acid-base disorder among the patients attending Nobel Medical College Teaching Hospital.

Journal of Nepal Medical Association, 2019
Introduction: Acid base disorder is a condition characterized by alteration in blood pH by the imbalance between the components of blood leading to a life threatening situation.
Rupesh Kumar Shreewastav, Krishna Pokhrel, Madan Pandey, Ganesh Prasad Singh, Arambam Giridhari Singh   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

ELECTROLYTES – SODIUM, POTASSIUM AND CHLORIDES IN POULTRY NUTRITION

Archives of Veterinary Medicine, 2016
Sodium, potassium and chlorides play a crucial role in maintaining body acid-base balance as well as osmotic pressure in body fluids. These processes are the result of synergetic action of all three elements, and the role of each individual component is ...
Milica Živkov Baloš, Sandra Jakšić, Slobodan Knežević, Miloš Kapetanov   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Multiple electrolyte imbalances and mixed acid-base disorder posing a diagnostic dilemma: a case report

Journal of Medical Case Reports, 2020
Background In clinical practice, both the history and laboratory testing are paramount to making an accurate diagnosis. Situations in which laboratory findings and patient history are not congruent pose a diagnostic dilemma.
Fortune O. Alabi, Christopher O. Alabi, Rafaela G. Basso, Nadia Lakhdar, Adebanke O. Oderinde   +4 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Comparison of low-cost interventions for pain during radial arterial blood gas sampling in the emergency department: a three-arm randomised controlled trial

Emergency Care Journal
This study evaluated the efficacy of topical anaesthesia and cryo-analgesia for pain management during radial Arterial Blood Gas (ABG) sampling, compared with standard care.  An open-label, randomised controlled trial with blinded statistical analysis in
Chawin Taveekijakarn, Tuntanut Lohawatcharagul, Supichaya Vitoonpanakoon, Pornchanok Sirisantisamrid, Thanathip Suenghataiphorn, Peerada Valyasevi, Ponphisudti Tangsirisatian   +6 more
doaj   +1 more source