Results 221 to 230 of about 41,686 (254)
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Acid-sensing ion channels and their modulators
Biochemistry (Moscow), 2014According to a modern look acid-sensing ion channels (ASICs) are one of the most important receptors that perceive pH change in the body. ASICs represent proton-gated Na+-selective channels, which are expressed in neurons of the central and peripheral nervous system.
D I, Osmakov, Ya A, Andreev, S A, Kozlov
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Ion conduction and selectivity in acid-sensing ion channel 1 [PDF]
Journal of General Physiology, 2014 The ability of acid-sensing ion channels (ASICs) to discriminate among cations was assessed based on changes in conductance and reversal potential with ion substitution. Human ASIC1a was expressed in Xenopus laevis oocytes, and acid-induced currents were measured using two-electrode voltage clamp.
Lei Yang +2 more
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Acid Sensing Ion Channels and Acid Nociception
Current Pharmaceutical Design, 2009Acid Sensing Ion Channels (ASICs) are a family of cation channels expressed principally in neurons and that are activated by protons. The sensitivity of ASICs to acidosis and their distribution in primary sensory neurons points to a significant role of these channels in acid nociception. However, despite the fact that the first ASIC was identified more
G R, Dubé, A, Elagoz, H, Mangat
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Peptides inhibitors of acid-sensing ion channels
Toxicon, 2007Acid-sensing ion channels (ASICs) channels are proton-gated cationic channels mainly expressed in central and peripheric nervous system and related to the epithelial amiloride-sensitive Na(+) channels and to the degenerin family of ion channels. ASICs comprise four proteins forming functional channel subunits (ASIC1a, ASIC1b, ASIC2a, and ASIC3) and two
Diochot, S. +4 more
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Identification of acid-sensing ion channels in bone
Biochemical and Biophysical Research Communications, 2005Bone balances serum pH variations and both osteoclasts and osteoblasts are regulated by subtle changes in pH. The aim of the current study was to identify molecules in bone that can sense pH. Interesting candidates are the acid-sensing ion channels (ASICs). In bone, ASIC2 and ASIC3 were most abundant, while in chondrocytes it was ASIC1.
Jahr, Holger +4 more
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Acid-sensing ion channels modulate bladder nociception
American Journal of Physiology-Renal Physiology, 2021Our study indicates that protons and their cognate acid-sensing ion channel receptors are part of a mechanism that operates at bladder afferent terminals to control their function and that the loss of this regulatory mechanism results in hyperactivation of nociceptive pathways and the development of pain in the setting of chemical-induced cystitis.
Nicolas Montalbetti +1 more
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Biophysical properties of acid-sensing ion channels (ASICs)
Neuropharmacology, 2015Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely sensitive to extracellular protons and can sense transient as well as sustained acidification. In this review, we will discuss activation and desensitization of ASICs by protons.
Grunder S, Pusch M
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Genetic exploration of the role of acid-sensing ion channels
Neuropharmacology, 2015Advanced gene targeting technology and related tools in mice have been incorporated into studies of acid-sensing ion channels (ASICs). A single ASIC subtype can be knocked out specifically and screened thoroughly for expression in the nervous system at the cellular level.
Shing-Hong, Lin +2 more
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Potentiation of acid-sensing ion channels by sulfhydryl compounds
American Journal of Physiology-Cell Physiology, 2007The acid-sensing ion channels (ASICs) are voltage-independent ion channels activated by acidic extracellular pH. ASICs play a role in sensory transduction, behavior, and acidotoxic neuronal death, which occurs during stroke and ischemia. During these conditions, the extracellular concentration of sulfhydryl reducing agents increases.
Jun-Hyeong, Cho, Candice C, Askwith
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