Results 231 to 240 of about 41,686 (254)

Targeting Acid-Sensing Ion Channels in Disease

Acidosis is a central feature of many pathological conditions, and while the activity of many ion channels is suppressed under acidic conditions, acid-sensing ion channels (ASICs) are exquisitely sensitive to decreases in pH and activated by protons. The expression and function of ASICs is enhanced under conditions of ischemia, inflammation, and trauma.
Senescall, Victor, Budusan, Elena, Knezic, Adriana, Waqar, Maleeha, Butcher, Neville, Khan, Nemat, McCarthy, Claudia, Widopp, Robert, Karatt-Vellat, Aneesh, Rash, Lachlan D.   +9 more
openaire   +2 more sources

Acid-Sensing Ion Channels

2023
Yangyu Wu, Cecilia M. Canessa
openaire   +1 more source

Acid‐sensing ion channels in allergic rhinitis

Clinical & Experimental Allergy, 2012
openaire   +3 more sources

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1

Journal of General Physiology, 2021
Matthew L Rook, Megan Miaro, Tyler Couch   +2 more
exaly  

Acid-Sensing Ion Channels

2013
Eric Lingueglia, Michel Lazdunski
openaire   +1 more source

Global Ischemia Induces Expression of Acid-Sensing Ion Channel 2a in Rat Brain

Journal of Cerebral Blood Flow and Metabolism, 2001
Martha B Johnson, Kunlin Jin, Dexi Chen   +2 more
exaly  

Acid-sensing ion channel 1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs

Expert Opinion on Therapeutic Targets, 2014
Xia Li, Wei Hu
exaly  

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model

Brain, 2011
Matthew J Craner, Kathrine E Attfield, Manuel A Friese   +2 more
exaly  

Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive

Proceedings of the National Academy of Sciences of the United States of America, 2017
David M Maclean, Vasanthi Jayaraman, David M Maclean   +2 more
exaly  

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3

Toxicon, 2009
Thomas Durek, Paul F Alewood, David J Adams   +2 more
exaly