Results 1 to 10 of about 1,823 (155)

ASIC1a senses lactate uptake to regulate metabolism in neurons

Redox Biology, 2022
Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations ...
Qin Hu, Tian-Le Xu, Qin Hu
exaly   +5 more sources

The Isolated Thumb Domain of Acid-Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies. [PDF]

Angew Chem Int Ed Engl
An independently folded thumb domain from acid‐sensing ion channels (ASICs) preserves ligand‐binding and proton‐sensing properties. NMR‐based interaction and pKa analyses uncover how endogenous and exogenous peptides modulate ASICs, providing a simplified model for rational drug discovery targeting proton‐gated ion channels.
Mishra BP, Cristofori-Armstrong B, Budusan E, Golder M, Butcher NJ, Liu J, Crawford T, Chin YK, Schmidt AP, Jia X, Smallwood TB, Clark RJ, Wurm JP, Rash LD, Mobli M.   +14 more
europepmc   +3 more sources

Acid-sensing ion channel 1a contributes to the calcium/calmodulin-dependent ferroptosis and aggravates intervertebral disc degeneration [PDF]

Redox Report
Objectives Acid-sensing ion channel 1a (ASIC1a) functions as an extracellular acid sensor, with its activation frequently associated with age-related diseases.
Lu-Ping Zhou, Jia-Qi Wang, Liang Kang, Yan-Xiang Hou, Xu Yan, Chen-Hao Zhao, Chong-Yu Jia, Hua-Qing Zhang, Ren-Jie Zhang, Cai-Liang Shen   +9 more
doaj   +2 more sources

Inhibition of ASIC1a Attenuates Neuronal Pyroptosis and Neuroinflammation Following Traumatic Brain Injury. [PDF]

CNS Neurosci Ther
This study identifies ASIC1a as a key modulator of neuroinflammation following traumatic brain injury. Pharmacological inhibition of ASIC1a mitigates neuronal pyroptosis and improves neurological outcomes, a protective effect closely associated with the downregulation of the NF‐κB/NLRP3 signaling axis.
Liang J, Chen P, Zhao Y, Lei P, Li Y, Zhang Y, Cai JH, Jiang YA, Zhang Y, Cheng S.   +9 more
europepmc   +2 more sources

Acid-sensing ion channel 1a deficiency drives endocrine hypertension in male mice. [PDF]

J Physiol
Abstract figure legend Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in aged male mice. Global deletion of ASIC1a (Asic1a−/−) in adult male mice (6 months old) elevates corticosterone, leading to hypokalaemia, volume expansion, increased pulse pressure and cardiomyocyte hypertrophy.
Garcia SM, Tuineau MN, DeLeon XA, Detweiler ND, Tamang S, Kanagy NL, Gonzalez Bosc LV, Resta TC, Naik JS, Jernigan NL.   +9 more
europepmc   +2 more sources

Role of Acid-Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota. [PDF]

Obesity (Silver Spring)
ABSTRACT Objective Acid‐sensing ion channels are proton‐activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear. This study investigates how systemic deletion of Asic1a influences obesity, metabolic, and gut‐based ...
Shearer J, Scantlebury MH, Erome-Utunedi O, Choudhary A, Thompson JA, Ohland C, McCoy KD, Mu C.   +7 more
europepmc   +2 more sources

Selective blockade of acid-sensing ion channel 1a can provide substantial hippocampal neuroprotection [PDF]

Frontiers in Cell and Developmental Biology
BackgroundAcid-sensing ion channel 1a (ASIC1a) is the only member of the ASIC family where Ca2+ osmosis has been reported, and it is highly expressed in neurons of the central nervous system.
Jiaai Li, Yu Cheng, Yu Cheng, Di Ma, Guangjian Li, Weixuan Zhao, Ting Jiang, Hongmei Meng   +7 more
doaj   +2 more sources

Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions. [PDF]

CNS Neurosci Ther
Carbogen, a low‐dose CO2/O2 mixture, modulates brain pH to suppress hyperexcitability through rapid and reversible pH‐dependent mechanisms distinct from conventional antiseizure medications (ASMs). Preclinical and small clinical studies show efficacy in focal and absence seizures, whereas variable responses in other types highlight the need for ...
Wang L, Liu Y, Ding W, Yang M, Liu Q, Xu F.   +5 more
europepmc   +2 more sources

Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment [PDF]

Biomolecules
Reactive astrogliosis and acidosis, common features of epileptogenic lesions, express a high level of astrocytic acid-sensing ion channel-1a (ASIC1a), a proton-gated cation channel and key mediator of responses to neuronal injury. This study investigates
Wen Li, Huimin Zhou, Xiaona Li, Gengyao Hu, Dong Wei   +4 more
doaj   +2 more sources

ASIC1a Promotes nucleus pulposus derived stem cells apoptosis through modulation of SIRT3-dependent mitochondrial redox homeostasis in intervertebral disc degeneration [PDF]

Redox Report
The death of human nucleus pulposus derived stem cells (NPSCs) is a key factor affecting the endogenous repair capability and degeneration of intervertebral discs (IVD).
Zhi-Gang Zhang, Liang Kang, Lu-Ping Zhou, Yan-Xin Wang, Chong-Yu Jia, Chen-Hao Zhao, Bo Zhang, Jia-Qi Wang, Hua-Qing Zhang, Ren-Jie Zhang, Cai-Liang Shen   +10 more
doaj   +2 more sources