Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a) [PDF]
Scientific Reports, 2018 Acid-Sensing Ion Channels (ASICs) are gated by extracellular protons and play important roles in physiological and pathological states, such as pain and stroke.
Yi Liu +2 more
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ASIC1a senses lactate uptake to regulate metabolism in neurons
Redox Biology, 2022 Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na+ and Ca2+-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations ...
Xin Qi, Qin Hu, Alexandra Stavsky
exaly +5 more sources
The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
Frontiers in Pharmacology, 2022 It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H+-activated cation channel family.
Huan Wang, Yancai Sun
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Acid-sensing ion channel 1a contributes to the calcium/calmodulin-dependent ferroptosis and aggravates intervertebral disc degeneration [PDF]
Redox ReportObjectives Acid-sensing ion channel 1a (ASIC1a) functions as an extracellular acid sensor, with its activation frequently associated with age-related diseases.
Lu-Ping Zhou +9 more
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ASIC1A in neurons is critical for fear‐related behaviors [PDF]
Genes, Brain and Behavior, 2017 Acid‐sensing ion channels (ASICs) have been implicated in fear‐, addiction‐ and depression‐related behaviors in mice. While these effects have been attributed to ASIC1A in neurons, it has been reported that ASICs may also function in nonneuronal cells. To determine if ASIC1A in neurons is indeed required, we generated neuron‐specific knockout (KO) mice
Rebecca J Taugher +2 more
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The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target
Current Neuropharmacology, 2021 Background: Epilepsy represents one of the most common brain diseases among humans. Tissue acidosis is a common phenomenon in epileptogenic foci. Moreover, its role in epileptogenesis remains unclear. Acid-sensing ion channel-1a (ASIC1a) represents a potential way to assess new therapies.
Wuqiong Zhang +2 more
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Selective blockade of acid-sensing ion channel 1a can provide substantial hippocampal neuroprotection [PDF]
Frontiers in Cell and Developmental BiologyBackgroundAcid-sensing ion channel 1a (ASIC1a) is the only member of the ASIC family where Ca2+ osmosis has been reported, and it is highly expressed in neurons of the central nervous system.
Jiaai Li +7 more
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Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment [PDF]
BiomoleculesReactive astrogliosis and acidosis, common features of epileptogenic lesions, express a high level of astrocytic acid-sensing ion channel-1a (ASIC1a), a proton-gated cation channel and key mediator of responses to neuronal injury. This study investigates
Wen Li +4 more
doaj +2 more sources
ASIC1a Promotes nucleus pulposus derived stem cells apoptosis through modulation of SIRT3-dependent mitochondrial redox homeostasis in intervertebral disc degeneration [PDF]
Redox ReportThe death of human nucleus pulposus derived stem cells (NPSCs) is a key factor affecting the endogenous repair capability and degeneration of intervertebral discs (IVD).
Zhi-Gang Zhang +10 more
doaj +2 more sources
The acid-sensing ion channel 1a modulates anxiety- and depression-related behaviors via its influencing on the activity of corticotropin-releasing hormone-expressing neurons in the hypothalamic paraventricular nucleus in male mice [PDF]
Translational PsychiatryA variety of studies show the involvement of acid-sensing ion channel 1a (ASIC1a) in the modulation of stress, however, the precise underlying mechanisms remain unclear.
Jiayin Yue +11 more
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