ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing
Frontiers in Neuroscience, 2015 Mice display an unconditioned freezing response to TMT, a predator odor isolated from fox feces. Here we found that in addition to freezing, TMT caused mice to decrease breathing rate, perhaps because of the aversive smell.
Rebecca J Taugher +2 more
exaly +4 more sources
ASIC1a contributes to the symptom of pain in a rat model of chronic prostatitis
Asian Journal of Andrology, 2018 This study aims to validate our hypothesis that acid-sensing ion channels (ASICs) may contribute to the symptom of pain in patients with chronic prostatitis (CP). We first established a CP rat model, then isolated the L5-S2 spinal dorsal horn neurons for
Song Fan +7 more
doaj +4 more sources
Targeting ASIC1a Promotes Neural Progenitor Cell Migration and Neurogenesis in Ischemic Stroke
Research, 2023 Cell replacement therapy using neural progenitor cells (NPCs) has been shown to be an effective treatment for ischemic stroke. However, the therapeutic effect is unsatisfactory due to the imbalanced homeostasis of the local microenvironment after ...
Hongfei Ge +11 more
doaj +2 more sources
PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner [PDF]
Molecular Brain, 2010 Background Acid-sensing ion channel 1a (ASIC1a) is the major ASIC subunit determining acid-activated currents in brain neurons. Recent studies show that ASIC1a play critical roles in acid-induced cell toxicity. While these studies raise the importance of
Jin Wenying +4 more
doaj +2 more sources
Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels [PDF]
ACS Chemical Neuroscience, 2018 Acid-sensing ion channels (ASICs) are neuronal Na+-selective ion channels that open in response to extracellular acidification. They are involved in pain, fear, learning, and neurodegeneration after ischemic stroke. 2-Guanidine-4-methylquinazoline (GMQ) was recently discovered as the first nonproton activator of ASIC3.
Alijevic, Omar +7 more
openaire +5 more sources
ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice [PDF]
Communications Biology, 2023 The body temperature of mice is higher at night than during the day. We show here that global deletion of acid-sensing ion channel 1a (ASIC1a) results in lower body temperature during a part of the night.
Zhong Peng +8 more
doaj +2 more sources
The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking. [PDF]
PLoS ONE, 2011 Acid-sensing ion channel-1a (ASIC1a), the primary proton receptor in the brain, contributes to multiple diseases including stroke, epilepsy and multiple sclerosis.
Lan Jing +5 more
doaj +2 more sources
Mechanism and site of action of big dynorphin on ASIC1a [PDF]
Proceedings of the National Academy of Sciences, 2019 Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as well as initiation of pain and neuronal death following ischemic stroke. As such, there is a great interest in understanding the in vivo regulation of ASICs, especially by endogenous neuropeptides that potently modulate ASICs.
Borg, Christian B. +13 more
openaire +7 more sources
The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface. [PDF]
PLoS ONE, 2015 The chicken acid-sensing ion channel ASIC1 has been crystallized as a homotrimer. We address here the oligomeric state of the functional ASIC1 in situ at the cell surface.
Miguel Xavier van Bemmelen +3 more
doaj +2 more sources
Zinc Permeation Through Acid-Sensing Ion Channels [PDF]
CellsAcid-sensing ion channels (ASICs), activated under acidic conditions, play a critical role in ischemic brain injury, but the detailed mechanisms and signaling pathways remain unclear.
Xiang-Ping Chu +2 more
doaj +2 more sources