Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a) [PDF]
Scientific Reports, 2018 Acid-Sensing Ion Channels (ASICs) are gated by extracellular protons and play important roles in physiological and pathological states, such as pain and stroke.
Yi Liu +2 more
doaj +3 more sources
The acid-sensing ion channel 1a modulates anxiety- and depression-related behaviors via its influencing on the activity of corticotropin-releasing hormone-expressing neurons in the hypothalamic paraventricular nucleus in male mice [PDF]
Translational PsychiatryA variety of studies show the involvement of acid-sensing ion channel 1a (ASIC1a) in the modulation of stress, however, the precise underlying mechanisms remain unclear.
Jiayin Yue +11 more
doaj +2 more sources
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression. [PDF]
Arch Pharm (Weinheim)Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Rychlik N +4 more
europepmc +2 more sources
The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
Frontiers in Pharmacology, 2022 It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H+-activated cation channel family.
Yinghong Wang +3 more
doaj +3 more sources
Zinc Permeation Through Acid-Sensing Ion Channels [PDF]
CellsAcid-sensing ion channels (ASICs), activated under acidic conditions, play a critical role in ischemic brain injury, but the detailed mechanisms and signaling pathways remain unclear.
Xiang-Ping Chu +2 more
doaj +2 more sources
Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2 [PDF]
Cellular & Molecular Biology LettersBackground Traumatic injuries to spinal cord lead to severe motor, sensory, and autonomic dysfunction. The accumulation of inhibitory compounds plays a pivotal role in the secondary damage to sparing neural tissue and the failure of axonal regeneration ...
Zuomeng Wu +7 more
doaj +2 more sources
Lacking ASIC1a in ASIC4-positive amygdala/bed nucleus of the stria terminalis (BNST) neurons reduces anxiety and innate fear in mice [PDF]
Journal of Biomedical ScienceBackground Anxiety is an innate response in the face of danger. When anxiety is overwhelming or persistent, it could be considered an anxiety disorder. Recent studies have shown that acid-sensing ion channels (ASICs) represent a novel class of promising ...
Ya-Chih Chien +4 more
doaj +2 more sources
Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis
Journal of Translational Medicine, 2022 Background Destruction of articular cartilage and bone is the main cause of joint dysfunction in rheumatoid arthritis (RA). Acid-sensing ion channel 1a (ASIC1a) is a key molecule that mediates the destruction of RA articular cartilage.
Zhuoyan Zai +10 more
doaj +3 more sources
ASIC1a contributes to the symptom of pain in a rat model of chronic prostatitis
Asian Journal of Andrology, 2018 This study aims to validate our hypothesis that acid-sensing ion channels (ASICs) may contribute to the symptom of pain in patients with chronic prostatitis (CP). We first established a CP rat model, then isolated the L5-S2 spinal dorsal horn neurons for
Song Fan +7 more
doaj +3 more sources
ASIC1a-Dependent Potentiation of Acid-Sensing Ion Channel Currents by Cyanide [PDF]
BiomoleculesCyanide (CN) is a potent, fast-acting toxicant that impacts endogenous biomolecules in the nervous system, including acid-sensing ion channels (ASICs), which play a vital role in various neurological and psychological conditions.
Qian Jiang +6 more
doaj +2 more sources