Results 41 to 50 of about 1,823 (155)
Molecular Brain, 2010 Background Acid-sensing ion channel 1a (ASIC1a) is the major ASIC subunit determining acid-activated currents in brain neurons. Recent studies show that ASIC1a play critical roles in acid-induced cell toxicity. While these studies raise the importance of
Jin Wenying +4 more
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Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction
eLife, 2015 Acidotoxicity is common among neurological disorders, such as ischemic stroke. Traditionally, Ca2+ influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered to be the leading cause of ischemic acidotoxicity. Here we show that extracellular
Yi-Zhi Wang +8 more
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The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking. [PDF]
PLoS ONE, 2011 Acid-sensing ion channel-1a (ASIC1a), the primary proton receptor in the brain, contributes to multiple diseases including stroke, epilepsy and multiple sclerosis.
Lan Jing +5 more
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Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels [PDF]
ACS Chemical Neuroscience, 2018 Acid-sensing ion channels (ASICs) are neuronal Na+-selective ion channels that open in response to extracellular acidification. They are involved in pain, fear, learning, and neurodegeneration after ischemic stroke. 2-Guanidine-4-methylquinazoline (GMQ) was recently discovered as the first nonproton activator of ASIC3.
Alijevic, Omar +7 more
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Biomolecules, 2020 Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions.
Qian Jiang +5 more
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ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing
Frontiers in Neuroscience, 2015 Mice display an unconditioned freezing response to TMT, a predator odor isolated from fox feces. Here we found that in addition to freezing, TMT caused mice to decrease breathing rate, perhaps because of the aversive smell.
Rebecca J. Taugher +10 more
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Biomedicines, 2021 Melanoma is an aggressive cancer characterized by the acidification of the extracellular environment. Here, we showed for the first time that extracellular media acidification increases proliferation, migration, and invasion of patient-derived metastatic
Maxim L. Bychkov +5 more
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Regulation of gliomagenesis and stemness through acid sensor ASIC1a
International Journal of Oncology, 2021 Glioblastoma multiforme (GBM) is the most prevalent and aggressive type of adult gliomas. Despite intensive therapy including surgery, radiation, and chemotherapy, invariable tumor recurrence occurs, which suggests that glioblastoma stem cells (GSCs) render these tumors persistent.
King, Pendelton +5 more
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Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a
Cell Death and Disease, 2022 Eliciting regulated cell death, like necroptosis, is a potential cancer treatment. However, pathways eliciting necroptosis are poorly understood. It has been reported that prolonged activation of acid-sensing ion channel 1a (ASIC1a) induces necroptosis ...
Jan Clusmann +9 more
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Frontiers in Pharmacology, 2022 Acidosis is a hallmark of ischemic stroke and a promising neuroprotective target for preventing neuronal injury. Previously, genetic manipulations showed that blockade of acid-sensing ion channel 1a (ASIC1a)-mediated acidotoxicity could dramatically ...
Xin Qi +19 more
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