Results 61 to 70 of about 2,309 (187)
ASIC1a inhibits cell pyroptosis induced by acid‐induced activation of rat hepatic stellate cells
FEBS Open Bio, 2020 The activation of hepatic stellate cells (HSCs) is associated with liver fibrosis, the pathological feature of most forms of chronic hepatic damage, and is accompanied by abnormal deposition of the extracellular matrix (ECM).
Jun Li +5 more
doaj +1 more source
Toxins, 2023 Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family.
Ekaterina N. Lyukmanova +8 more
doaj +1 more source
Functional expression of concatenated ASIC1a fusion proteins.
, 2015 A: Representative recording of an ASIC1a current in Xenopus oocytes expressing a fusion protein made of three ASIC1a subunit proteins, each with intact C-termini, and linked in a head to tail fashion (3xFP).
Delphine Huser (781307) +3 more
core +1 more source
Effects of PcTx1 and mambalgin-1 on ASIC1a homomeric and heteromeric channels.
, 2023 A, Typical ASIC1a, ASIC1a/2a and ASIC1a/2b currents recorded at -50 mV from HEK293 transfected cells following extracellular acidification to pH5.0. B, Statistical analysis of the current densities recorded in A.
Ludivine Pidoux (12871781) +9 more
core +1 more source
Cell Death Discovery, 2023 Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues ...
Zhenyu Zhang +10 more
doaj +1 more source
Acid-Sensing Ion Channels in Glial Cells
Membranes, 2022 Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells.
Victoria Cegielski +5 more
doaj +1 more source
Loss of ASIC1a prevents airway hyperreactivity.
, 2016 A) Male mice (8–9 weeks-old) were sensitized by intraperitoneal injection of 10 μg of OVA (Sigma) mixed with 1 mg of alum in 0.9% saline on days 0 and 7. Control mice received saline with 1 mg of alum at day 0 and 7.
Leah R. Reznikov (674878) +9 more
core +1 more source
Coordinated Movements During ASIC1A Activity
Biophysical Journal, 2014 Acid-sensing ion channels (ASICs) are H+-gated and Na+-conducting channels predominantly expressed in the nervous system. They are involved in H+ sensing in many physiological and pathological states such as ischemia and pain perception. The crystal structure of the chicken ASIC1 isoform has been revealed in the desensitized and the open state ...
Bonifacio, Gaetano +2 more
openaire +1 more source
, 2015 A: Effects of extracellular (black bars) or intracellular (grey bars) perfusion of NaTT (20 mM) on ASIC1a currents measured in Xenopus oocytes before (t = 0) and after perfusion (t = 2min.). Bars represents means ± SE (n = 28).
Delphine Huser (781307) +3 more
core +1 more source
ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain
eLife, 2021 Accumulating evidence has shown transcranial low-intensity ultrasound can be potentially a non-invasive neural modulation tool to treat brain diseases.
Jormay Lim +13 more
doaj +1 more source