Results 61 to 70 of about 1,823 (155)

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

An iEEG investigation on sex‐specific differences in seizure duration

Epilepsia Open, Volume 11, Issue 3, Page 912-921, June 2026.
Abstract Objective Male people with epilepsy (mPWE) are at higher risk for bilateral tonic–clonic seizures (BTCs) and sudden unexpected death in epilepsy (SUDEP) compared to female people with epilepsy (fPWE). Despite major clinical and personal implications, little is known about sex‐specific differences in seizure propagation and termination ...
Paula Albert I Gracenea, Alexandra Muss, Magdalena Seethaler, Jan Rémi, Elisabeth Kaufmann   +4 more
wiley   +1 more source

Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. [PDF]

PLoS ONE, 2016
Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR.
Leah R Reznikov, David K Meyerholz, Ryan J Adam, Mahmoud Abou Alaiwa, Omar Jaffer, Andrew S Michalski, Linda S Powers, Margaret P Price, David A Stoltz, Michael J Welsh   +9 more
doaj   +1 more source

Role of ASIC1a in Aβ-induced synaptic alterations in the hippocampus

Pharmacological Research, 2018
Acid-sensing ion channels (ASICs) are widely expressed in the mammalian central nervous system where they play a key role in synaptic transmission and in specific forms of memory. On the other hand, ASICs can be persistently active under pathological conditions contributing to neuronal damage in ischemic stroke, brain trauma, epilepsy and Parkinson's ...
Mango, D, Nisticò, R
openaire   +4 more sources

The effects of acid-sensing ion channel-1A on conditioned fear memory are age-dependent

IBRO Neuroscience Reports
The neuronal circuits underlying Pavlovian fear conditioning have been suggested to undergo marked changes during brain development. One molecule that is expressed in the brain during early development and that plays a key role in fear learning and fear ...
R.J. Taugher-Hebl, A. Berns, M. Jones, A. Townsend, A. Eagen, Langbehn, DR, H. Janouschek, MD   +6 more
doaj   +1 more source

Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation. [PDF]

PLoS ONE, 2013
Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel that contributes to fear and pain as well as neuronal damage following persistent cerebral acidosis.
Erin N Frey, Ryan E Pavlovicz, Clem John Wegman, Chenglong Li, Candice C Askwith   +4 more
doaj   +1 more source

Epilepsy: Molecular Pathogenesis and Emerging Therapies

MedComm, Volume 7, Issue 4, April 2026.
Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Wanbin Huang, Jiabin Zong, Yu Zhang, Ming Li, Songqing Pan, Zheman Xiao   +5 more
wiley   +1 more source

ASIC1a activation by amitriptyline and FMRF-amide is removed by serine proteases [PDF]

Channels, 2008
Analgesia induced by certain tricyclic antidepressants has been largely used for decades, yet the mechanisms involved are incompletely understood. Starting from previously reported dual effects of amitriptyline on wild-type ENaC (Pena F, et al. J Pharm Pharmacol 54:1393-8: 2002), we extended our study to ASIC1a by performing a series of whole cell and ...
Adela N, Marin, Corina M, Prica, Bogdan P, Amuzescu, Emil I, Neaga, Maria-Luiza G, Flonta   +4 more
openaire   +2 more sources

Molecular basis of inhibition of acid sensing ion channel 1A by diminazene. [PDF]

PLoS ONE, 2018
Acid-sensing ion channels (ASICs) are trimeric proton-gated cation permeable ion channels expressed primarily in neurons. Here we employed site-directed mutagenesis and electrophysiology to investigate the mechanism of inhibition of ASIC1a by diminazene.
Aram J Krauson, James G Rooney, Marcelo D Carattino   +2 more
doaj   +1 more source

Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling.

PLoS Computational Biology, 2023
Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity mechanisms that can lead to chronic pain states. Windup is a well-known spinal pain facilitation process initially described several decades
Magda Chafaï, Ariane Delrocq, Perrine Inquimbert, Ludivine Pidoux, Kevin Delanoe, Maurizio Toft, Frederic Brau, Eric Lingueglia, Romain Veltz, Emmanuel Deval   +9 more
doaj   +1 more source