Results 71 to 80 of about 2,309 (187)
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, Volume 13, Issue 33, 15 June 2026.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
Functional characteristics of the ASIC1a constructs.
, 2015 ASIC1a currents (INa) were elicited at pH 6.0. ΔCCt denotes ASIC1a mutant lacking the cysteines in the C-terminus. BMOE (2mM), Cd2+ and DTT (10 mM) were added in the extracellular medium.** denotes statistical significance ...
Delphine Huser (781307) +3 more
core +1 more source
Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway
, 2021 Oxidative stress is intimately tied to neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis, and acute injuries, such as ischemic stroke and traumatic brain injury.
Bao-ming Wu +11 more
core +1 more source
An iEEG investigation on sex‐specific differences in seizure duration
Epilepsia Open, Volume 11, Issue 3, Page 912-921, June 2026.Abstract Objective Male people with epilepsy (mPWE) are at higher risk for bilateral tonic–clonic seizures (BTCs) and sudden unexpected death in epilepsy (SUDEP) compared to female people with epilepsy (fPWE). Despite major clinical and personal implications, little is known about sex‐specific differences in seizure propagation and termination ...
Paula Albert I Gracenea +4 more
wiley +1 more source
Mutating Tyr71 and Trp287 reduces dendritic targeting of ASIC1a.
, 2013 ASIC2-/- hippocampal slices were co-transfected with HA-tagged wild-type ASIC1a, W287G or Y71G mutants together with a membrane targeted Lck-GFP [22]. Localization of transfected ASIC1a was visualized by immunofluorescence using an anti-HA antibody.
Xiang-ming Zha (340963) +5 more
core +1 more source
Hippocampal NG2 cells express ASIC1a subunit proteins.
, 2013 (A) An example of images showing NG2 immunoreactivity of CA1 stratum radiatum. Dashed circles denote NG2 immunoreactive cells. Dashed lines demarcate the border between stratum radiatum and stratum pyramidale. Scale bar, 30 µm. (B) The same slice showing
Cheng-Chang Lien (361760) +3 more
core +1 more source
Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. [PDF]
PLoS ONE, 2016 Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR.
Leah R Reznikov +9 more
doaj +1 more source
Loss of ASIC1a did not affect neurodegeneration after MPTP.
, 2016 Mice received either subacute MPTP treatment or saline only. Dopaminergic (TH-positive) cells (A) and Nissl-positive cells (B) were stereologically counted in one hemisphere of the SNc after 14 days.
Arno Reich (163313) +4 more
core +1 more source
Role of ASIC1a in Aβ-induced synaptic alterations in the hippocampus
Pharmacological Research, 2018 Acid-sensing ion channels (ASICs) are widely expressed in the mammalian central nervous system where they play a key role in synaptic transmission and in specific forms of memory. On the other hand, ASICs can be persistently active under pathological conditions contributing to neuronal damage in ischemic stroke, brain trauma, epilepsy and Parkinson's ...
Mango, D, Nisticò, R
openaire +4 more sources
, 2015 A-B: Anti-ASIC1a western blot of surface biotinylated fractions of oocytes, treated with vehicle or with BMOE (0.5 or 2 mM) before lysis, expressing either ASIC1a wt or G433C (A) or 3ASICFP (3xFP) or 4ASICFP (4xFP) (B).
Delphine Huser (781307) +3 more
core +1 more source