Results 71 to 80 of about 1,823 (155)
Acta Physiologica, Volume 242, Issue 3, March 2026.ABSTRACT Aim Controversy exists on which metabolites determine the exaggerated exercise pressor reflex (EPR) in peripheral artery disease (PAD). In decerebrated rats, we investigated the role played by lactate and hydrogen ions in a model of PAD, which was simulated by ligating the femoral artery for 72 h before the start of the experiment.
Guillaume P. Ducrocq +3 more
wiley +1 more source
Independent Contribution of Extracellular Proton Binding Sites to ASIC1a Activation [PDF]
Journal of Biological Chemistry, 2013 Acid-sensing ion channels (ASICs) are a group of trimeric cation permeable channels gated by extracellular protons that are mainly expressed in the nervous system. Despite the structural information available for ASIC1, there is limited understanding of the molecular mechanism that allows these channels to sense and respond to drops in extracellular pH.
Aram J, Krauson +2 more
openaire +2 more sources
Physiological Reports, Volume 14, Issue 5, March 2026.Abstract Cardiac afferent neurons have been shown to trigger overactivation of neurohormonal systems known to drive adverse cardiac remodeling following myocardial infarction (MI). Acid‐sensing ion channels (ASICs) that are highly expressed in cardiac sympathetic afferents sense ischemia‐induced myocardial acidosis.
Karley M. Monaghan +14 more
wiley +1 more source
International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.Background Melanoma is an aggressive and highly lethal form of skin cancer, with pronounced cellular heterogeneity contributing to drug resistance and clinical challenges. Therefore, identifying reliable biomarkers and developing robust prognostic models are critical for improving clinical management and enabling personalized treatment.
Wei Wang +5 more
wiley +1 more source
NMDAR-Mediated Hippocampal Neuronal Death is Exacerbated by Activities of ASIC1a [PDF]
Neurotoxicity Research, 2015 NMDARs and ASIC1a both exist in central synapses and mediate important physiological and pathological conditions, but the functional relationship between them is unclear. Here we report several novel findings that may shed light on the functional relationship between these two ion channels in the excitatory postsynaptic membrane of mouse hippocampus ...
Su, Gao +9 more
openaire +2 more sources
The Role of Neuro‐Immune Regulation in the Pathogenesis of Psoriasis
Journal of Immunology Research, Volume 2026, Issue 1, 2026.Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory neurons in the initiation and progression of psoriatic ...
Xin Liu +10 more
wiley +1 more source
Gating‐associated conformational changes in the pore of ASIC1a
The FASEB Journal, 2010 Acid‐sensing ion channels (ASICs) are trimeric cation channels that undergo concerted activation and desensitization in response to extracellular acidification. Each subunit has two transmembrane domains (TMs) connected by a large extracellular region with intracellular N‐ and C‐ terminus.
Lindsey A Tolino +2 more
openaire +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2020 Acid-sensing ion channels (ASICs) are H+-activated neuronal Na+ channels. They are involved in fear behavior, learning, neurodegeneration after ischemic stroke and in pain sensation.
Omar Alijevic +6 more
doaj +1 more source
Ecosystem services provided by spiders
Biological Reviews, Volume 100, Issue 6, Page 2217-2236, December 2025.ABSTRACT Spiders, ubiquitous and abundant predators in terrestrial ecosystems, often are the subjects of an unjust negative perception. However, these remarkable creatures stand as unsung heroes within our ecosystems, contributing a multitude of ecosystem services critical to human well‐being.
Pedro Cardoso +13 more
wiley +1 more source