Results 51 to 60 of about 2,309 (187)
Biomolecules, 2020 Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions.
Qian Jiang +5 more
doaj +1 more source
Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction
eLife, 2015 Acidotoxicity is common among neurological disorders, such as ischemic stroke. Traditionally, Ca2+ influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered to be the leading cause of ischemic acidotoxicity. Here we show that extracellular
Yi-Zhi Wang +8 more
doaj +1 more source
Distance in ASIC1a WT between mutated residues.
, 2022 Distance in ASIC1a WT between mutated residues.
Stephan Kellenberger (5042927) +1 more
core +1 more source
Biomedicines, 2021 Melanoma is an aggressive cancer characterized by the acidification of the extracellular environment. Here, we showed for the first time that extracellular media acidification increases proliferation, migration, and invasion of patient-derived metastatic
Maxim L. Bychkov +5 more
doaj +1 more source
Regulation of gliomagenesis and stemness through acid sensor ASIC1a
International Journal of Oncology, 2021 Glioblastoma multiforme (GBM) is the most prevalent and aggressive type of adult gliomas. Despite intensive therapy including surgery, radiation, and chemotherapy, invariable tumor recurrence occurs, which suggests that glioblastoma stem cells (GSCs) render these tumors persistent.
King, Pendelton +5 more
openaire +3 more sources
Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a
Cell Death and Disease, 2022 Eliciting regulated cell death, like necroptosis, is a potential cancer treatment. However, pathways eliciting necroptosis are poorly understood. It has been reported that prolonged activation of acid-sensing ion channel 1a (ASIC1a) induces necroptosis ...
Jan Clusmann +9 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are largely expressed in the mammalian nervous system. ASIC1a is highly permeable to Ca2+ and are involved in many physiological processes, including synaptic
D. Mango, R. Nisticò, R. Nisticò
doaj +1 more source
Conformational Changes Associated with Proton-dependent Gating of ASIC1a [PDF]
Journal of Biological Chemistry, 2009 Acid-sensing ion channels are proton-gated Na(+) channels expressed predominantly in neurons. How channel structure translates an environmental stimulus into changes in pore permeability remains largely undefined. The pore of ASIC1 is defined by residues in the second transmembrane domain (TM2), although a segment of the outer vestibule is formed by ...
Christopher J, Passero +2 more
openaire +2 more sources
PLoS ONE, 2020 Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist and play important roles in vasoreactivity.
Selina M Garcia +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Acidosis is a hallmark of ischemic stroke and a promising neuroprotective target for preventing neuronal injury. Previously, genetic manipulations showed that blockade of acid-sensing ion channel 1a (ASIC1a)-mediated acidotoxicity could dramatically ...
Xin Qi +19 more
doaj +1 more source