Results 51 to 60 of about 1,823 (155)

Acid-Sensing Ion Channel 1a Is Involved in N-Methyl D-Aspartate Receptor-Dependent Long-Term Depression in the Hippocampus

Frontiers in Pharmacology, 2019
Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are largely expressed in the mammalian nervous system. ASIC1a is highly permeable to Ca2+ and are involved in many physiological processes, including synaptic
D. Mango, R. Nisticò, R. Nisticò
doaj   +1 more source

Conformational Changes Associated with Proton-dependent Gating of ASIC1a [PDF]

Journal of Biological Chemistry, 2009
Acid-sensing ion channels are proton-gated Na(+) channels expressed predominantly in neurons. How channel structure translates an environmental stimulus into changes in pore permeability remains largely undefined. The pore of ASIC1 is defined by residues in the second transmembrane domain (TM2), although a segment of the outer vestibule is formed by ...
Christopher J, Passero, Sora, Okumura, Marcelo D, Carattino   +2 more
openaire   +2 more sources

Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries.

PLoS ONE, 2020
Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist and play important roles in vasoreactivity.
Selina M Garcia, Lindsay M Herbert, Benjimen R Walker, Thomas C Resta, Nikki L Jernigan   +4 more
doaj   +1 more source

ASIC1a inhibits cell pyroptosis induced by acid‐induced activation of rat hepatic stellate cells

FEBS Open Bio, 2020
The activation of hepatic stellate cells (HSCs) is associated with liver fibrosis, the pathological feature of most forms of chronic hepatic damage, and is accompanied by abnormal deposition of the extracellular matrix (ECM).
Jun Li, Lingjin Kong, Huiping Huang, Shaohua Luan, Rui Jin, Fanrong Wu   +5 more
doaj   +1 more source

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells

Toxins, 2023
Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family.
Ekaterina N. Lyukmanova, Maxim M. Zaigraev, Dmitrii S. Kulbatskii, Aizek B. Isaev, Ilya D. Kukushkin, Maxim L. Bychkov, Mikhail A. Shulepko, Anton O. Chugunov, Mikhail P. Kirpichnikov   +8 more
doaj   +1 more source

Coordinated Movements During ASIC1A Activity

Biophysical Journal, 2014
Acid-sensing ion channels (ASICs) are H+-gated and Na+-conducting channels predominantly expressed in the nervous system. They are involved in H+ sensing in many physiological and pathological states such as ischemia and pain perception. The crystal structure of the chicken ASIC1 isoform has been revealed in the desensitized and the open state ...
Bonifacio, Gaetano, Suenaga lelli, Claudia, Kellenberger, Stephan   +2 more
openaire   +1 more source

Acid-Sensing Ion Channels in Glial Cells

Membranes, 2022
Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells.
Victoria Cegielski, Rohan Chakrabarty, Shinghua Ding, Michael J. Wacker, Paula Monaghan-Nichols, Xiang-Ping Chu   +5 more
doaj   +1 more source

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu, Zhixing Hao, Lili Li, Huiying Liu, Chenghui Yang, Zhen Wang   +5 more
wiley   +1 more source

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Cell Death Discovery, 2023
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues ...
Zhenyu Zhang, Minnan Chen, Wenjing Zhan, Yuechun Chen, Tongtong Wang, Zhonghua Chen, Yifei Fu, Gang Zhao, Dong Mao, Jingjing Ruan, Feng-Lai Yuan   +10 more
doaj   +1 more source

ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

eLife, 2021
Accumulating evidence has shown transcranial low-intensity ultrasound can be potentially a non-invasive neural modulation tool to treat brain diseases.
Jormay Lim, Hsiao-Hsin Tai, Wei-Hao Liao, Ya-Cherng Chu, Chen-Ming Hao, Yueh-Chun Huang, Cheng-Han Lee, Shao-Shien Lin, Sherry Hsu, Ya-Chih Chien, Dar-Ming Lai, Wen-Shiang Chen, Chih-Cheng Chen, Jaw-Lin Wang   +13 more
doaj   +1 more source