Results 31 to 40 of about 1,823 (155)
Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse
Frontiers in Molecular Biosciences, 2023 Drugs of abuse produce rearrangements at glutamatergic synapses thought to contribute to drug-reinforced behaviors. Acid-Sensing Ion Channels (ASICs) have been suggested to oppose these effects, largely due to observations in mice lacking the ASIC1A ...
Margaret J. Fuller +22 more
doaj +1 more source
Effects of acid-sensing ion channel-1A (ASIC1A) on cocaine-induced synaptic adaptations
Frontiers in Physiology, 2023 Chronic drug abuse is thought to induce synaptic changes in nucleus accumbens medium spiny neurons (MSNs) that promote subsequent craving and drug-seeking behavior. Accumulating data suggest acid-sensing ion channels (ASICs) may play a critical role.
Subhash C. Gupta +17 more
doaj +1 more source
Opening the Pore of ASIC1a [PDF]
Biophysical Journal, 2011 Acid-sensing ion channels (ASICs) are voltage-independent proton-gated ion channels expressed throughout neurons of the mammalian central and peripheral nervous systems. These channels are organized as homo- or hetero-trimers. Each subunit has two transmembrane segments (TMs) connected by a large extracellular region with the N- and C- termini on the ...
Tolino, Lindsey A. +3 more
openaire +1 more source
A Gating Mutation in the Internal Pore of ASIC1a [PDF]
Journal of Biological Chemistry, 2006 Using a substituted cysteine accessibility scan, we have investigated the structures that form the internal pore of the acid-sensing ion channel 1a. We have identified the amino acid residues Ala-22, Ile-33, and Phe-34 in the amino terminus and Arg-43 in the first transmembrane helix, which when mutated into cysteine, were modified by intracellular ...
Pfister Y +5 more
openaire +3 more sources
Diminazene Interaction with ASIC1A Channels [PDF]
Biophysical Journal, 2014 Diaryldiamidines, a class of DNA minor groove binders used clinically since the 1940s in the treatment of tropical parasitoses such as trypanosomiasis, leishmaniasis, pneumocystis pneumonia and babesiosis, have been recently found to exert specific blocking effects on acid-sensing ion channels (ASIC), raising hopes to develop new small molecule ...
Amuzescu, Bogdan P. +4 more
openaire +1 more source
Signaling Pathways in Proton and Non-proton ASIC1a Activation [PDF]
Frontiers in Cellular Neuroscience, 2021 Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases as well as pain conditions. Classically, ASICs are described as transiently activated by a reduced pH, followed by desensitization; the activation allows sodium influx, and in the case of ASIC1a-composed channels, also calcium to some ...
Libia Catalina Salinas Castellanos +2 more
openaire +4 more sources
CaM/CaMKII mediates activation and proliferation of hepatic stellate cells regulated by ASIC1a
Frontiers in Pharmacology, 2022 The activation of hepatic stellate cells (HSCs) is closely related to hepatic fibrosis and plays a key role in its occurrence and development. In the damaged liver, inhibition of the activation, proliferation, and clearance of HSCs is an important ...
Hui Liu +30 more
doaj +1 more source
The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface. [PDF]
PLoS ONE, 2015 The chicken acid-sensing ion channel ASIC1 has been crystallized as a homotrimer. We address here the oligomeric state of the functional ASIC1 in situ at the cell surface.
Miguel Xavier van Bemmelen +3 more
doaj +1 more source
Mechanism and site of action of big dynorphin on ASIC1a [PDF]
Proceedings of the National Academy of Sciences, 2019 Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as well as initiation of pain and neuronal death following ischemic stroke. As such, there is a great interest in understanding the in vivo regulation of ASICs, especially by endogenous neuropeptides that potently modulate ASICs.
Borg, Christian B. +13 more
openaire +5 more sources
ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice
Communications Biology, 2023 The body temperature of mice is higher at night than during the day. We show here that global deletion of acid-sensing ion channel 1a (ASIC1a) results in lower body temperature during a part of the night.
Zhong Peng +8 more
doaj +1 more source