Results 31 to 40 of about 2,309 (187)

Acid-sensing ion channel 1a deficiency drives endocrine hypertension in male mice. [PDF]

J Physiol
Abstract figure legend Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in aged male mice. Global deletion of ASIC1a (Asic1a−/−) in adult male mice (6 months old) elevates corticosterone, leading to hypokalaemia, volume expansion, increased pulse pressure and cardiomyocyte hypertrophy.
Garcia SM, Tuineau MN, DeLeon XA, Detweiler ND, Tamang S, Kanagy NL, Gonzalez Bosc LV, Resta TC, Naik JS, Jernigan NL.   +9 more
europepmc   +2 more sources

Identification and analgesic activity study of analgesic protein Ⅶ-2 from Naja naja atra venom [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: Acid-sensing ion channel 1a (ASIC1a) plays a critical role in physiological and pathological processes. To further elucidate the biological functions of ASICs and their relationships with disease occurrence and development, it is ...
Yao Sun, Gen-Bao Zhang, Shu Li, Xiao-Yu Liu, Lei Chen, Peng-Ju Bao   +5 more
doaj   +2 more sources

Role of Acid-Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota. [PDF]

Obesity (Silver Spring)
ABSTRACT Objective Acid‐sensing ion channels are proton‐activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear. This study investigates how systemic deletion of Asic1a influences obesity, metabolic, and gut‐based ...
Shearer J, Scantlebury MH, Erome-Utunedi O, Choudhary A, Thompson JA, Ohland C, McCoy KD, Mu C.   +7 more
europepmc   +2 more sources

Seizure termination by acidosis depends on ASIC1a [PDF]

Nature Neuroscience, 2008
Most seizures stop spontaneously; however, the molecular mechanisms that terminate seizures remain unknown. Observations that seizures reduced brain pH and that acidosis inhibited seizures indicate that acidosis halts epileptic activity. Because acid-sensing ion channel 1a (ASIC1a) is exquisitely sensitive to extracellular pH and regulates neuron ...
Adam E, Ziemann, Mikael K, Schnizler, Gregory W, Albert, Meryl A, Severson, Matthew A, Howard, Michael J, Welsh, John A, Wemmie   +6 more
openaire   +5 more sources

Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions. [PDF]

CNS Neurosci Ther
Carbogen, a low‐dose CO2/O2 mixture, modulates brain pH to suppress hyperexcitability through rapid and reversible pH‐dependent mechanisms distinct from conventional antiseizure medications (ASMs). Preclinical and small clinical studies show efficacy in focal and absence seizures, whereas variable responses in other types highlight the need for ...
Wang L, Liu Y, Ding W, Yang M, Liu Q, Xu F.   +5 more
europepmc   +2 more sources

Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension

Frontiers in Molecular Biosciences, 2022
Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that conducts both Na+ and Ca2+. Activation of ASIC1a elicits plasma membrane depolarization and stimulates intracellular Ca2+-dependent signaling pathways in ...
Selina M. Garcia, Tracy R. Yellowhair, Neil D. Detweiler, Rosstin Ahmadian, Lindsay M. Herbert, Laura V. Gonzalez Bosc, Thomas C. Resta, Nikki L. Jernigan   +7 more
doaj   +1 more source

Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis

Frontiers in Immunology, 2021
Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation channel family. Emerging evidence has suggested that ASIC1a plays a crucial role in the pathogenesis of rheumatoid arthritis (RA).
Yayun Xu, Yayun Xu, Yayun Xu, Feihu Chen, Feihu Chen, Feihu Chen   +5 more
doaj   +1 more source

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a. [PDF]

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019
Acid-sensing ion channels (ASICs) are the major proton receptor in the brain and a key mediator of acidosis-induced neuronal injuries in disease. Most of published data on ASIC function came from studies performed in mice, and relatively little is known about potential differences between human and mouse ASICs (hASIC and mASIC, respectively).
Yuanyuan, Xu, Yu-Qing, Jiang, Ce, Li, Mindi, He, W George, Rusyniak, Naga, Annamdevula, Juan, Ochoa, Silas J, Leavesley, Jiangping, Xu, Thomas C, Rich, Mike T, Lin, Xiang-Ming, Zha   +11 more
openaire   +5 more sources

Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket

, 2021
Prolonged acidosis, as it occurs during ischemic stroke, induces neuronal death via acid-sensing ion channel 1a (ASIC1a). Concomitantly, it desensitizes ASIC1a, highlighting the pathophysiological significance of modulators of ASIC1a acid sensitivity ...
Michèle Bachmann (11356946), Lilia Leisle (11356934), Giulia Rossetti (471944), Stefan Gründer, Audrey Ortega-Ramírez (11356940), Lilia Leisle, Michael Margreiter (11356937), Audrey Ortega-Ramírez, Giulia Rossetti, Michèle Bachmann, Stefan Gründer (11356949), Elinor Cleuvers, Michael Margreiter, Elinor Cleuvers (11356943)   +13 more
core   +3 more sources

Gating Transitions in the Palm Domain of ASIC1a* [PDF]

Journal of Biological Chemistry, 2013
Acid-sensing ion channels (ASICs) are trimeric cation-selective proton-gated ion channels expressed in the central and peripheral nervous systems. The pore-forming transmembrane helices in these channels are linked by short loops to the palm domain in the extracellular region.
Margaret C, Della Vecchia, Anna C, Rued, Marcelo D, Carattino   +2 more
openaire   +2 more sources