Results 21 to 30 of about 2,309 (187)

Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2 [PDF]

Cellular & Molecular Biology Letters
Background Traumatic injuries to spinal cord lead to severe motor, sensory, and autonomic dysfunction. The accumulation of inhibitory compounds plays a pivotal role in the secondary damage to sparing neural tissue and the failure of axonal regeneration ...
Zuomeng Wu, Tianyu Han, Yixiang Dong, Wang Ying, Huang Fang, Yunlei Liu, Peiwen Song, Cailiang Shen   +7 more
doaj   +2 more sources

Lacking ASIC1a in ASIC4-positive amygdala/bed nucleus of the stria terminalis (BNST) neurons reduces anxiety and innate fear in mice [PDF]

Journal of Biomedical Science
Background Anxiety is an innate response in the face of danger. When anxiety is overwhelming or persistent, it could be considered an anxiety disorder. Recent studies have shown that acid-sensing ion channels (ASICs) represent a novel class of promising ...
Ya-Chih Chien, Shing-Hong Lin, Cheng-Chang Lien, John N. Wood, Chih-Cheng Chen   +4 more
doaj   +2 more sources

Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis

Journal of Translational Medicine, 2022
Background Destruction of articular cartilage and bone is the main cause of joint dysfunction in rheumatoid arthritis (RA). Acid-sensing ion channel 1a (ASIC1a) is a key molecule that mediates the destruction of RA articular cartilage.
Zhuoyan Zai, Yayun Xu, Xuewen Qian, Zihan Li, Ziyao Ou, Tao Zhang, Longfei Wang, Yian Ling, Xiaoqing Peng, Yihao Zhang, Feihu Chen   +10 more
doaj   +3 more sources

Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry [PDF]

Cell Calcium, 2009
Acid Sensing Ion Channels (ASICs) are a family of proton-gated cation channels that play a role in the sensation of noxious stimuli. Of these, ASIC1a is the only family member that is reported to be permeable to Ca(2+), although the absolute magnitude of the Ca(2+) current is unclear.
Amy B Harkins, Terrance M Egan
exaly   +3 more sources

Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis

Journal of Inflammation Research, 2021
Xiaoyu Hang,1,2 Zhenyu Zhang,1,2 Ruowen Niu,1,2 Chen Wang,1,2 Jing Yao,1,2 Yayun Xu,1,2 Jingjing Tao,1,2 Lanlan Li,1,2 Feihu Chen1,2 1Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, Hefei, 230032 ...
Hang X, Zhang Z, Niu R, Wang C, Yao J, Xu Y, Tao J, Li L, Chen F   +8 more
doaj   +5 more sources

ASIC1a-Dependent Potentiation of Acid-Sensing Ion Channel Currents by Cyanide [PDF]

Biomolecules
Cyanide (CN) is a potent, fast-acting toxicant that impacts endogenous biomolecules in the nervous system, including acid-sensing ion channels (ASICs), which play a vital role in various neurological and psychological conditions.
Qian Jiang, Felix Yang, Amber Sun, Yuyang Chu, Joseph Cascone, Dylan Glaser, Xiang-Ping Chu   +6 more
doaj   +2 more sources

The Isolated Thumb Domain of Acid-Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies. [PDF]

Angew Chem Int Ed Engl
An independently folded thumb domain from acid‐sensing ion channels (ASICs) preserves ligand‐binding and proton‐sensing properties. NMR‐based interaction and pKa analyses uncover how endogenous and exogenous peptides modulate ASICs, providing a simplified model for rational drug discovery targeting proton‐gated ion channels.
Mishra BP, Cristofori-Armstrong B, Budusan E, Golder M, Butcher NJ, Liu J, Crawford T, Chin YK, Schmidt AP, Jia X, Smallwood TB, Clark RJ, Wurm JP, Rash LD, Mobli M.   +14 more
europepmc   +3 more sources

α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala [PDF]

Experimental Biology and Medicine
Epilepsy affects more than 70 million people worldwide. A seizure focus that develops in different cortical brain regions can present as either focal or generalized seizures.
Volodymyr I. Pidoplichko, Taiza H. Figueiredo, Maria F. M. Braga, Ann M. Marini   +3 more
doaj   +2 more sources

Mutagenesis of the Peptide Inhibitor of ASIC3 Channel Introduces Binding to Thumb Domain of ASIC1a but Reduces Analgesic Activity [PDF]

Marine Drugs
Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic plasticity, anxiety ...
Timur A. Khasanov, Ekaterina E. Maleeva, Sergey G. Koshelev, Victor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Sergey A. Kozlov, Yaroslav A. Andreev, Dmitry I. Osmakov   +8 more
doaj   +2 more sources

Inhibition of ASIC1a Attenuates Neuronal Pyroptosis and Neuroinflammation Following Traumatic Brain Injury. [PDF]

CNS Neurosci Ther
This study identifies ASIC1a as a key modulator of neuroinflammation following traumatic brain injury. Pharmacological inhibition of ASIC1a mitigates neuronal pyroptosis and improves neurological outcomes, a protective effect closely associated with the downregulation of the NF‐κB/NLRP3 signaling axis.
Liang J, Chen P, Zhao Y, Lei P, Li Y, Zhang Y, Cai JH, Jiang YA, Zhang Y, Cheng S.   +9 more
europepmc   +2 more sources