Results 21 to 30 of about 1,823 (155)

α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala [PDF]

Experimental Biology and Medicine
Epilepsy affects more than 70 million people worldwide. A seizure focus that develops in different cortical brain regions can present as either focal or generalized seizures.
Volodymyr I. Pidoplichko, Taiza H. Figueiredo, Maria F. M. Braga, Ann M. Marini   +3 more
doaj   +2 more sources

Mutagenesis of the Peptide Inhibitor of ASIC3 Channel Introduces Binding to Thumb Domain of ASIC1a but Reduces Analgesic Activity [PDF]

Marine Drugs
Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic plasticity, anxiety ...
Timur A. Khasanov, Ekaterina E. Maleeva, Sergey G. Koshelev, Victor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Sergey A. Kozlov, Yaroslav A. Andreev, Dmitry I. Osmakov   +8 more
doaj   +2 more sources

Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis

Journal of Inflammation Research, 2021
Xiaoyu Hang,1,2 Zhenyu Zhang,1,2 Ruowen Niu,1,2 Chen Wang,1,2 Jing Yao,1,2 Yayun Xu,1,2 Jingjing Tao,1,2 Lanlan Li,1,2 Feihu Chen1,2 1Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, Hefei, 230032 ...
Hang X, Zhang Z, Niu R, Wang C, Yao J, Xu Y, Tao J, Li L, Chen F   +8 more
doaj   +5 more sources

Identification and analgesic activity study of analgesic protein Ⅶ-2 from Naja naja atra venom [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: Acid-sensing ion channel 1a (ASIC1a) plays a critical role in physiological and pathological processes. To further elucidate the biological functions of ASICs and their relationships with disease occurrence and development, it is ...
Yao Sun, Gen-Bao Zhang, Shu Li, Xiao-Yu Liu, Lei Chen, Peng-Ju Bao   +5 more
doaj   +2 more sources

Seizure termination by acidosis depends on ASIC1a [PDF]

Nature Neuroscience, 2008
Most seizures stop spontaneously; however, the molecular mechanisms that terminate seizures remain unknown. Observations that seizures reduced brain pH and that acidosis inhibited seizures indicate that acidosis halts epileptic activity. Because acid-sensing ion channel 1a (ASIC1a) is exquisitely sensitive to extracellular pH and regulates neuron ...
Adam E, Ziemann, Mikael K, Schnizler, Gregory W, Albert, Meryl A, Severson, Matthew A, Howard, Michael J, Welsh, John A, Wemmie   +6 more
openaire   +5 more sources

Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension

Frontiers in Molecular Biosciences, 2022
Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that conducts both Na+ and Ca2+. Activation of ASIC1a elicits plasma membrane depolarization and stimulates intracellular Ca2+-dependent signaling pathways in ...
Selina M. Garcia, Tracy R. Yellowhair, Neil D. Detweiler, Rosstin Ahmadian, Lindsay M. Herbert, Laura V. Gonzalez Bosc, Thomas C. Resta, Nikki L. Jernigan   +7 more
doaj   +1 more source

Targeting ASIC1a Promotes Neural Progenitor Cell Migration and Neurogenesis in Ischemic Stroke

Research, 2023
Cell replacement therapy using neural progenitor cells (NPCs) has been shown to be an effective treatment for ischemic stroke. However, the therapeutic effect is unsatisfactory due to the imbalanced homeostasis of the local microenvironment after ...
Hongfei Ge, Tengyuan Zhou, Chao Zhang, Yupeng Cun, Weixiang Chen, Yang Yang, Qian Zhang, Huanhuan Li, Jun Zhong, Xuyang Zhang, Hua Feng, Rong Hu   +11 more
doaj   +1 more source

Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis

Frontiers in Immunology, 2021
Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation channel family. Emerging evidence has suggested that ASIC1a plays a crucial role in the pathogenesis of rheumatoid arthritis (RA).
Yayun Xu, Yayun Xu, Yayun Xu, Feihu Chen, Feihu Chen, Feihu Chen   +5 more
doaj   +1 more source

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a. [PDF]

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019
Acid-sensing ion channels (ASICs) are the major proton receptor in the brain and a key mediator of acidosis-induced neuronal injuries in disease. Most of published data on ASIC function came from studies performed in mice, and relatively little is known about potential differences between human and mouse ASICs (hASIC and mASIC, respectively).
Yuanyuan, Xu, Yu-Qing, Jiang, Ce, Li, Mindi, He, W George, Rusyniak, Naga, Annamdevula, Juan, Ochoa, Silas J, Leavesley, Jiangping, Xu, Thomas C, Rich, Mike T, Lin, Xiang-Ming, Zha   +11 more
  +7 more sources

Gating Transitions in the Palm Domain of ASIC1a* [PDF]

Journal of Biological Chemistry, 2013
Acid-sensing ion channels (ASICs) are trimeric cation-selective proton-gated ion channels expressed in the central and peripheral nervous systems. The pore-forming transmembrane helices in these channels are linked by short loops to the palm domain in the extracellular region.
Margaret C, Della Vecchia, Anna C, Rued, Marcelo D, Carattino   +2 more
openaire   +2 more sources