Results 1 to 10 of about 41,686 (254)

Acid-Sensing Ion Channel 2: Function and Modulation [PDF]

Membranes, 2022
Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family.
Andy Sivils, Felix Yang, John Q. Wang, Xiang-Ping Chu   +3 more
doaj   +5 more sources

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention [PDF]

Cell Death Discovery, 2023
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues ...
Zhenyu Zhang, Minnan Chen, Wenjing Zhan, Yuechun Chen, Tongtong Wang, Zhonghua Chen, Yifei Fu, Gang Zhao, Dong Mao, Jingjing Ruan, Feng-Lai Yuan   +10 more
doaj   +2 more sources

Acid-sensing ion channel 3: An analgesic target. [PDF]

Channels (Austin), 2021
Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation by extracellular protons mediate a transient inward current inducing cellular excitability.
Dulai JS, Smith ESJ, Rahman T.
europepmc   +5 more sources

The Role of Zinc in Modulating Acid-Sensing Ion Channel Function [PDF]

Biomolecules, 2023
Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium channels widely expressed throughout the central and peripheral nervous systems. They are involved in synaptic plasticity, learning/memory, fear conditioning and pain.
Amber W. Sun, Michelle H. Wu, Madhumathi Vijayalingam, Michael J. Wacker, Xiang-Ping Chu   +4 more
doaj   +2 more sources

Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a [PDF]

eLife, 2023
Acid-sensing ion channels (ASICs) are trimeric proton-gated sodium channels. Recent work has shown that these channels play a role in necroptosis following prolonged acidic exposure like occurs in stroke.
Megan M Cullinan, Robert C Klipp, Abigail Camenisch, John R Bankston   +3 more
doaj   +2 more sources

ASIC1a-Dependent Potentiation of Acid-Sensing Ion Channel Currents by Cyanide [PDF]

Biomolecules
Cyanide (CN) is a potent, fast-acting toxicant that impacts endogenous biomolecules in the nervous system, including acid-sensing ion channels (ASICs), which play a vital role in various neurological and psychological conditions.
Qian Jiang, Felix Yang, Amber Sun, Yuyang Chu, Joseph Cascone, Dylan Glaser, Xiang-Ping Chu   +6 more
doaj   +2 more sources

Insulin enhances acid-sensing ion channel currents in rat primary sensory neurons [PDF]

Scientific Reports
Insulin has been shown to modulate neuronal processes through insulin receptors. The ion channels located on neurons may be important targets for insulin/insulin receptor signaling.
Zhong-Qing Xu, Ting-Ting Liu, Qing-Rui Qin, Huan Yuan, Xue-Mei Li, Chun-Yu Qiu, Wang-Ping Hu   +6 more
doaj   +2 more sources

Identification of the modulatory Ca2+-binding sites of acid-sensing ion channel 1a [PDF]

Open Biology
Acid-sensing ion channels (ASICs) are neuronal Na+-permeable ion channels activated by extracellular acidification. ASICs are involved in learning, fear sensing, pain sensation and neurodegeneration.
Ophélie Molton, Olivier Bignucolo, Stephan Kellenberger   +2 more
doaj   +2 more sources

Acid-sensing ion channel 1a: a novel target in Alzheimer’s disease? [PDF]

Neural Regeneration Research, 2023
Dalila Mango, Robert Nisticò
doaj   +2 more sources

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells

Toxins, 2023
Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family.
Ekaterina N. Lyukmanova, Maxim M. Zaigraev, Dmitrii S. Kulbatskii, Aizek B. Isaev, Ilya D. Kukushkin, Maxim L. Bychkov, Mikhail A. Shulepko, Anton O. Chugunov, Mikhail P. Kirpichnikov   +8 more
doaj   +1 more source