Results 21 to 30 of about 41,686 (254)
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
Frontiers in Cellular Neuroscience, 2021 Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango +3 more
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Acid-sensing ion channels under hypoxia [PDF]
Channels, 2013 Hypoxia represents the lack of oxygen below the basic level, and the range of known channels related to hypoxia is continually increasing. Since abnormal hypoxia initiates pathological processes in numerous diseases via, to a great degree, producing acidic microenvironment, the significance of these channels in this environment has, until now, remained
Guo, Yingjun, Qu, Xun
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Basics on the use of acid-sensing ion channels’ inhibitors as therapeutics
Neural Regeneration Research, 2019 Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases
Jamileh Dibas +2 more
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Acid-sensing ion channels: trafficking and pathophysiology [PDF]
Channels, 2014 Acid-sensing ion channels (ASICs) are proton-gated cation channels that are widely expressed in both the peripheral and central nervous systems. ASICs contribute to a variety of pathophysiological conditions that involve tissue acidosis, such as ischemic stroke, epileptic seizures and multiple sclerosis.
Wei-Zheng, Zeng +2 more
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The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
Frontiers in Pharmacology, 2022 It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H+-activated cation channel family.
Yinghong Wang +3 more
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Acid-sensing Ion Channels in Malignant Gliomas [PDF]
Journal of Biological Chemistry, 2003 High grade glioma cells derived from patient biopsies express an amiloride-sensitive sodium conductance that has properties attributed to the human brain sodium channel family, also known as acid-sensing ion channels (ASICs). This amiloride-sensitive conductance was not detected in cells obtained from normal brain tissue or low grade or benign tumors ...
Bakhrom K, Berdiev +12 more
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Tumor Biology, 2017 Acid-sensing ion channels, a proton-gated cation channel, can be activated by low extracellular pH and involved in pathogenesis of some tumors such as glioma and breast cancer.
Yu Wu +5 more
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Pancreatic ductal bicarbonate secretion: challenge of the acinar acid load
Frontiers in Physiology, 2011 Acinar and ductal cells of the exocrine pancreas form a close functional unit. Although most studies contain data either on acinar or ductal cells, an increasing number of evidence highlights the importance of the pancreatic acinar-ductal functional unit.
Peter eHegyi +3 more
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Molecular Pain, 2017 Tachyphylaxis of itch refers to a markedly reduced scratching response to consecutive exposures of a pruritogen, a process thought to protect against tissue damage by incessant scratching and to become disrupted in chronic itch.
Yi-Ming Jiang +6 more
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Acid-Sensing Ion Channels Contribute to Neurotoxicity [PDF]
Translational Stroke Research, 2013 Acidosis that occurs under pathological conditions not only affects intracellular signaling molecules, but also directly activates a unique family of ligand-gated ion channels: acid-sensing ion channels (ASICs). ASICs are widely expressed throughout the central and peripheral nervous systems and play roles in pain sensation, learning and memory, and ...
Xiang-Ping, Chu +2 more
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