Results 21 to 30 of about 41,896 (210)
Proton-binding sites of acid-sensing ion channel 1.
PLoS ONE, 2011 Acid-sensing ion channels (ASICs) are proton-gated cation channels that exist throughout the mammalian central and peripheral nervous systems. ASIC1 is the most abundant of all the ASICs and is likely to modulate synaptic transmission.
Hiroshi Ishikita
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An acid-sensing ion channel that detects ischemic pain
Brazilian Journal of Medical and Biological Research, 2005 Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The pain of a heart attack is the prototypical example. Multiple compounds released from ischemic muscle likely contribute to this pain by acting on sensory ...
L.A. Naves, E.W. McCleskey
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Bio-Protocol, 2017 Two-Electrode Voltage-Clamp (TEVC) recording in Xenopus laevis oocytes provides a powerful method to investigate the functions and regulation of ion channel proteins.
cun wang, Jingbo Zhang, Julian Schroeder
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Neural Regeneration Research, 2016 Ischemic postconditioning renders brain tissue tolerant to brain ischemia, thereby alleviating ischemic brain injury. However, the exact mechanism of action is still unclear.
Wang-sheng Duanmu +5 more
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Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. [PDF]
PLoS ONE, 2016 Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR.
Leah R Reznikov +9 more
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Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels
eLife, 2015 Tarantula toxins that bind to voltage-sensing domains of voltage-activated ion channels are thought to partition into the membrane and bind to the channel within the bilayer.
Kanchan Gupta +9 more
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Nature Communications, 2020 Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto ...
Jing-Jing Wang +8 more
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ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand
Cell Reports, 2015 The regulation and mechanisms underlying itch sensation are complex. Here, we report a role for acid-sensing ion channel 3 (ASIC3) in mediating itch evoked by certain pruritogens during tissue acidosis.
Zhong Peng +7 more
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Molecular basis of inhibition of acid sensing ion channel 1A by diminazene. [PDF]
PLoS ONE, 2018 Acid-sensing ion channels (ASICs) are trimeric proton-gated cation permeable ion channels expressed primarily in neurons. Here we employed site-directed mutagenesis and electrophysiology to investigate the mechanism of inhibition of ASIC1a by diminazene.
Aram J Krauson +2 more
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Acid sensing ion channel 1 in lateral hypothalamus contributes to breathing control. [PDF]
PLoS ONE, 2012 Acid-sensing ion channels (ASICs) are present in neurons and may contribute to chemoreception. Among six subunits of ASICs, ASIC1 is mainly expressed in the central nervous system. Recently, multiple sites in the brain including the lateral hypothalamus (
Nana Song +9 more
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