Results 31 to 40 of about 41,686 (254)
Proton-binding sites of acid-sensing ion channel 1.
PLoS ONE, 2011 Acid-sensing ion channels (ASICs) are proton-gated cation channels that exist throughout the mammalian central and peripheral nervous systems. ASIC1 is the most abundant of all the ASICs and is likely to modulate synaptic transmission.
Hiroshi Ishikita
doaj +1 more source
Acid-Sensing Ion Channels in Postoperative Pain [PDF]
The Journal of Neuroscience, 2011 Iatrogenic pain consecutive to a large number of surgical procedures has become a growing health concern. The etiology and pathophysiology of postoperative pain are still poorly understood, but hydrogen ions appear to be important in this process. We have investigated the role of peripheral acid-sensing ion channels (ASICs), which form depolarizing ...
Deval, Emmanuel +8 more
openaire +2 more sources
Bio-Protocol, 2017 Two-Electrode Voltage-Clamp (TEVC) recording in Xenopus laevis oocytes provides a powerful method to investigate the functions and regulation of ion channel proteins.
cun wang, Jingbo Zhang, Julian Schroeder
doaj +1 more source
Neural Regeneration Research, 2016 Ischemic postconditioning renders brain tissue tolerant to brain ischemia, thereby alleviating ischemic brain injury. However, the exact mechanism of action is still unclear.
Wang-sheng Duanmu +5 more
doaj +1 more source
Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. [PDF]
PLoS ONE, 2016 Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR.
Leah R Reznikov +9 more
doaj +1 more source
Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels
eLife, 2015 Tarantula toxins that bind to voltage-sensing domains of voltage-activated ion channels are thought to partition into the membrane and bind to the channel within the bilayer.
Kanchan Gupta +9 more
doaj +1 more source
Acid-Sensing Ion Channels in Pathological Conditions [PDF]
, 2012 Acid-sensing ion channels (ASICs), a novel family of proton-gated amiloride-sensitive cation channels, are expressed primarily in neurons of peripheral sensory and central nervous systems. Recent studies have shown that activation of ASICs, particularly the ASIC1a channels, plays a critical role in neuronal injury associated with neurological disorders
Xiang-Ping, Chu, Zhi-Gang, Xiong
openaire +2 more sources
Gating mechanisms of acid-sensing ion channels [PDF]
Nature, 2018 Acid-sensing ion channels (ASICs) are trimeric, proton-gated and sodium-selective members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout vertebrate central and peripheral nervous systems.
Nate, Yoder +2 more
openaire +2 more sources
Nature Communications, 2020 Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto ...
Jing-Jing Wang +8 more
doaj +1 more source
ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand
Cell Reports, 2015 The regulation and mechanisms underlying itch sensation are complex. Here, we report a role for acid-sensing ion channel 3 (ASIC3) in mediating itch evoked by certain pruritogens during tissue acidosis.
Zhong Peng +7 more
doaj +1 more source