Results 11 to 20 of about 41,896 (210)
Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. [PDF]
PLoS ONE, 2013 It has been reported that both activation of N-methyl-D-aspartate receptors and acid-sensing ion channels during cerebral ischemic insult contributed to brain injury.
Kwok Keung Tai, Daniel D Truong
doaj +1 more source
Topography and motion of acid-sensing ion channel intracellular domains
eLife, 2021 Acid-sensing ion channels (ASICs) are trimeric cation-selective channels activated by decreases in extracellular pH. The intracellular N and C terminal tails of ASIC1 influence channel gating, trafficking, and signaling in ischemic cell death.
Tyler Couch +5 more
doaj +1 more source
Ion Channel Genes in Painful Neuropathies
Biomedicines, 2023 Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets.
Milena Ślęczkowska +4 more
doaj +1 more source
The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a)
Biomolecules, 2021 Acid-sensing ion channels (ASICs) are ionotropic receptors that are directly activated by protons. Although protons have been shown to act as a neurotransmitter and to activate ASICs during synaptic transmission, it remains a possibility that other ...
Sven Kuspiel +2 more
doaj +1 more source
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
Frontiers in Cellular Neuroscience, 2021 Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango +3 more
doaj +1 more source
Basics on the use of acid-sensing ion channels’ inhibitors as therapeutics
Neural Regeneration Research, 2019 Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases
Jamileh Dibas +2 more
doaj +1 more source
The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
Frontiers in Pharmacology, 2022 It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H+-activated cation channel family.
Yinghong Wang +3 more
doaj +1 more source
Tumor Biology, 2017 Acid-sensing ion channels, a proton-gated cation channel, can be activated by low extracellular pH and involved in pathogenesis of some tumors such as glioma and breast cancer.
Yu Wu +5 more
doaj +1 more source
Pancreatic ductal bicarbonate secretion: challenge of the acinar acid load
Frontiers in Physiology, 2011 Acinar and ductal cells of the exocrine pancreas form a close functional unit. Although most studies contain data either on acinar or ductal cells, an increasing number of evidence highlights the importance of the pancreatic acinar-ductal functional unit.
Peter eHegyi +3 more
doaj +1 more source
Molecular Pain, 2017 Tachyphylaxis of itch refers to a markedly reduced scratching response to consecutive exposures of a pruritogen, a process thought to protect against tissue damage by incessant scratching and to become disrupted in chronic itch.
Yi-Ming Jiang +6 more
doaj +1 more source