Results 11 to 20 of about 41,686 (254)
An acid-sensing ion channel that detects ischemic pain [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The pain of a heart attack is the prototypical example. Multiple compounds released from ischemic muscle likely contribute to this pain by acting on sensory ...
L.A. Naves, E.W. McCleskey
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Acid-Sensing Ion Channels in Zebrafish [PDF]
Animals, 2021 The ASICs, in mammals as in fish, control deviations from the physiological values of extracellular pH, and are involved in mechanoreception, nociception, or taste receptions. They are widely expressed in the central and peripheral nervous system. In this review, we summarized the data about the presence and localization of ASICs in different organs of
Montalbano, Giuseppe +7 more
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Acid-Sensing Ion Channels and Mechanosensation [PDF]
International Journal of Molecular Sciences, 2021 Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium channel superfamily due to their sodium permeability. Predominantly expressed in the central nervous system, ASICs are involved in synaptic plasticity, learning/memory, and fear
Nina Ruan +5 more
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Acid-Sensing Ion Channels in Glial Cells [PDF]
Membranes, 2022 Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells. While there has been a lot of focus on ASIC in neurons, less is known about the roles of ASICs in glial cells.
Victoria Cegielski +5 more
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Acid-Sensing Ion Channels and Pain [PDF]
Pharmaceuticals, 2010 Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems.
Qihai Gu, Lu-Yuan Lee
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Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. [PDF]
PLoS ONE, 2013 It has been reported that both activation of N-methyl-D-aspartate receptors and acid-sensing ion channels during cerebral ischemic insult contributed to brain injury.
Kwok Keung Tai, Daniel D Truong
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Topography and motion of acid-sensing ion channel intracellular domains
eLife, 2021 Acid-sensing ion channels (ASICs) are trimeric cation-selective channels activated by decreases in extracellular pH. The intracellular N and C terminal tails of ASIC1 influence channel gating, trafficking, and signaling in ischemic cell death.
Tyler Couch +5 more
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Acid-sensing ion channels in sensory signaling [PDF]
American Journal of Physiology-Renal Physiology, 2020 Acid-sensing ion channels (ASICs) are cation-permeable channels that in the periphery are primarily expressed in sensory neurons that innervate tissues and organs. Soon after the cloning of the ASIC subunits, almost 20 yr ago, investigators began to use genetically modified mice to assess the role of these channels in physiological processes.
Marcelo D. Carattino +1 more
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Ion Channel Genes in Painful Neuropathies
Biomedicines, 2023 Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets.
Milena Ślęczkowska +4 more
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The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a)
Biomolecules, 2021 Acid-sensing ion channels (ASICs) are ionotropic receptors that are directly activated by protons. Although protons have been shown to act as a neurotransmitter and to activate ASICs during synaptic transmission, it remains a possibility that other ...
Sven Kuspiel +2 more
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