Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a [PDF]
eLife, 2023 Acid-sensing ion channels (ASICs) are trimeric proton-gated sodium channels. Recent work has shown that these channels play a role in necroptosis following prolonged acidic exposure like occurs in stroke.
Megan M Cullinan +3 more
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Identification of the modulatory Ca2+-binding sites of acid-sensing ion channel 1a [PDF]
Open Biology, 2023 Acid-sensing ion channels (ASICs) are neuronal Na+-permeable ion channels activated by extracellular acidification. ASICs are involved in learning, fear sensing, pain sensation and neurodegeneration.
Ophélie Molton +2 more
doaj +6 more sources
Molecular basis of inhibition of acid sensing ion channel 1A by diminazene. [PDF]
PLoS ONE, 2018 Acid-sensing ion channels (ASICs) are trimeric proton-gated cation permeable ion channels expressed primarily in neurons. Here we employed site-directed mutagenesis and electrophysiology to investigate the mechanism of inhibition of ASIC1a by diminazene.
Aram J Krauson +2 more
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Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline [PDF]
Biomolecules, 2019 Acid-sensing ion channels (ASICs) are proton-gated sodium-selective channels that are expressed in the peripheral and central nervous systems. ASIC1a is one of the most intensively studied isoforms due to its importance and wide representation in ...
Dmitry I. Osmakov +6 more
doaj +5 more sources
Effects of acid-sensing ion channel-1A (ASIC1A) on cocaine-induced synaptic adaptations [PDF]
Frontiers in Physiology, 2023 Chronic drug abuse is thought to induce synaptic changes in nucleus accumbens medium spiny neurons (MSNs) that promote subsequent craving and drug-seeking behavior. Accumulating data suggest acid-sensing ion channels (ASICs) may play a critical role.
Subhash C. Gupta +17 more
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The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a) [PDF]
Biomolecules, 2021 Acid-sensing ion channels (ASICs) are ionotropic receptors that are directly activated by protons. Although protons have been shown to act as a neurotransmitter and to activate ASICs during synaptic transmission, it remains a possibility that other ...
Sven Kuspiel +2 more
doaj +6 more sources
Acid-sensing ion channel 1a: a novel target in Alzheimer’s disease? [PDF]
Neural Regeneration Research, 2023 Dalila Mango, Robert Nisticò
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Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties [PDF]
Toxins, 2019 Acid-sensing ion channels (ASICs), which are present in almost all types of neurons, play an important role in physiological and pathological processes. The ASIC1a subtype is the most sensitive channel to the medium’s acidification, and it plays an
Dmitry I. Osmakov +7 more
doaj +4 more sources
Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses [PDF]
JCI Insight, 2022 Recent research on altering threat memory has focused on a reconsolidation window. During reconsolidation, threat memories are retrieved and become labile.
Erin E. Koffman +10 more
doaj +5 more sources
Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment [PDF]
BiomoleculesReactive astrogliosis and acidosis, common features of epileptogenic lesions, express a high level of astrocytic acid-sensing ion channel-1a (ASIC1a), a proton-gated cation channel and key mediator of responses to neuronal injury. This study investigates
Wen Li +4 more
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