Results 41 to 50 of about 20,488 (221)
Nature Communications, 2020 Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto ...
Jing-Jing Wang +8 more
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Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Chronic Epileptogenesis [PDF]
Scientific Reports, 2016 AbstractUnraveling mechanisms underlying epileptogenesis after brain injury is an unmet medical challenge. Although histopathological studies have revealed that reactive astrogliosis and tissue acidosis are prominent features in epileptogenic foci, their roles in epileptogenesis remain unclear.
Feng Yang +9 more
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Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a) [PDF]
Molecular Pharmacology, 2017 Acid-sensing ion channels (ASICs) are neuronal receptors for extracellular protons. They contribute to the excitatory postsynaptic current and to the detection of painful acidosis. Moreover, they are activated during peripheral inflammation and acidosis associated with various neuronal disorders, such as stroke and neuroinflammation, rendering them ...
Axel, Schmidt +3 more
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PT718. HISTAMINE SELECTIVELY POTENTIATES ACID-SENSING ION CHANNEL 1A [PDF]
Int J Neuropsychopharmacol, 2016 E.I. N, T.B T, N.N P, L.G M, D.B T.
europepmc +3 more sources
Tumor Biology, 2017 Acid-sensing ion channels, a proton-gated cation channel, can be activated by low extracellular pH and involved in pathogenesis of some tumors such as glioma and breast cancer.
Yu Wu +5 more
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Permeating protons contribute to tachyphylaxis of the acid‐sensing ion channel (ASIC) 1a [PDF]
The Journal of Physiology, 2007 The homomeric acid‐sensing ion channel 1a (ASIC1a) is a H+‐activated ion channel with important physiological functions and pathophysiological impact in the central nervous system. Here we show that homomeric ASIC1a is distinguished from other ASICs by a reduced response to successive acid stimulations.
Chen, Xuanmao, Grunder, Stefan
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Reversible Slow Desensitization of the Acid-Sensing Ion Channel (ASIC) 1a [PDF]
, 2021 Abstract Among the proton-activated channels of the ASIC family, ASIC1a exhibits a specific tachyphylaxis phenomenon in the form of a progressive decrease in the response amplitude during a series of activations. This process is well known, but its mechanism is poorly understood.
Margarita S Komarova +3 more
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Neuropeptide Interaction with the Extracellular Domain of the Acid Sensing Ion Channel 1A [PDF]
Biophysical Journal, 2012 Acidic fluctuations occur within the brain and contribute to multiple physiological and patho-physiological processes. Neurons possess specific molecules to sense and respond to these pH changes. In particular, many neurons express the acid sensing ion channels (ASICs). ASICs are ligand-gated ion channels activated by extracellular protons.
Sherwood, Thomas +3 more
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The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function. [PDF]
PLoS ONE, 2010 Degenerin/epithelial Na(+) channels (DEG/ENaC) represent a diverse family of voltage-insensitive cation channels whose functions include Na(+) transport across epithelia, mechanosensation, nociception, salt sensing, modification of neurotransmission, and
Yehuda Ben-Shahar +5 more
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Modulation of Human Acid-Sensing Ion Channel 1A Open Channel Inactivation by FRRFamide [PDF]
Biophysical Journal, 2012 The ASICs (Acid-Sensing Ion Channels) are involved in neuronal signaling in the central and peripheral nervous system. These non-voltage-gated channels are involved in learning, the expression of fear, neurodegeneration after ischemia, and pain sensation. The molecular bases underlying their activity are not yet fully understood.
Bargeton, Benoite +4 more
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