Correction: Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography. [PDF]
PLoS ONE, 2018 [This corrects the article DOI: 10.1371/journal.pone.0202134.].
Nate Yoder, Eric Gouaux
doaj +2 more sources
Coupling of store-operated calcium entry to vasoconstriction is acid-sensing ion channel 1a dependent in pulmonary but not mesenteric arteries. [PDF]
PLoS ONE, 2020 Although voltage-gated Ca2+ channels (VGCC) are a major Ca2+ entry pathway in vascular smooth muscle cells (VSMCs), several other Ca2+-influx mechanisms exist and play important roles in vasoreactivity.
Selina M Garcia +4 more
doaj +2 more sources
Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons [PDF]
Frontiers in Cellular Neuroscience, 2020 Acid-sensing ion channels (ASICs) are H+-activated neuronal Na+ channels. They are involved in fear behavior, learning, neurodegeneration after ischemic stroke and in pain sensation.
Omar Alijevic +6 more
doaj +2 more sources
Acid-Sensing Ion Channel 1a Is Involved in N-Methyl D-Aspartate Receptor-Dependent Long-Term Depression in the Hippocampus [PDF]
Frontiers in Pharmacology, 2019 Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are largely expressed in the mammalian nervous system. ASIC1a is highly permeable to Ca2+ and are involved in many physiological processes, including synaptic
D. Mango, R. Nisticò, R. Nisticò
doaj +2 more sources
Accelerated Current Decay Kinetics of a Rare Human Acid-Sensing ion Channel 1a Variant That Is Used in Many Studies as Wild Type [PDF]
Frontiers in Molecular Neuroscience, 2019 Acid-sensing ion channels (ASICs) are neuronal Na+-permeable ion channels that are activated by extracellular acidification and are involved in fear sensing, learning, neurodegeneration after ischemia, and in pain sensation.
Anand Vaithia +4 more
doaj +2 more sources
The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target
Frontiers in Pharmacology, 2022 It is acknowledged that chronic inflammation is associated with a rise in extracellular proton concentrations. The acid-sensing ion channel 1a (ASIC1a) belongs to the extracellular H+-activated cation channel family.
Yinghong Wang +3 more
doaj +1 more source
Insights into the Mechanism of Pore Opening of Acid-sensing Ion Channel 1A [PDF]
Journal of Biological Chemistry, 2011 Acid-sensing ion channels (ASICs) are trimeric cation channels that undergo activation and desensitization in response to extracellular acidification. The underlying mechanism coupling proton binding in the extracellular region to pore gating is unknown.
Lindsey A, Tolino +3 more
openaire +2 more sources
Activation of Acid-sensing Ion Channel 1a (ASIC1a) by Surface Trafficking [PDF]
Journal of Biological Chemistry, 2010 Acid-sensing ion channels (ASICs) are voltage-independent Na(+) channels activated by extracellular protons. ASIC1a is expressed in neurons in mammalian brain and is implicated in long term potentiation of synaptic transmission that contributes to learning and memory.
Sunghee, Chai +4 more
openaire +2 more sources
Trypsin Cleaves Acid-sensing Ion Channel 1a in a Domain That Is Critical for Channel Gating [PDF]
Journal of Biological Chemistry, 2006 Acid-sensing ion channels (ASICs) are neuronal Na(+) channels that are members of the epithelial Na(+) channel/degenerin family and are transiently activated by extracellular acidification. ASICs in the central nervous system have a modulatory role in synaptic transmission and are involved in cell injury induced by acidosis.
Vukicevic M +4 more
openaire +3 more sources
Gating Mechanism and Movements in Acid Sensing Ion Channel 1A [PDF]
Biophysical Journal, 2015 Acid Sensing Ion Channels (ASICs) are proton sensitive ion channels found in central and peripheral nervous system. They are involved in a variety of physiological processes including sensory perception, synaptic transmission and nociception. It is also involved in pathological processes like stroke and hypoxia leading to cell death. Thus understanding
Ramaswamy, Swarna S. +3 more
openaire +1 more source