Results 21 to 30 of about 20,488 (221)

Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis [PDF]

Frontiers in Immunology, 2021
Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation channel family. Emerging evidence has suggested that ASIC1a plays a crucial role in the pathogenesis of rheumatoid arthritis (RA).
Yayun Xu, Yayun Xu, Yayun Xu, Feihu Chen, Feihu Chen, Feihu Chen   +5 more
doaj   +2 more sources

The acid-sensing ion channel 1a modulates anxiety- and depression-related behaviors via its influencing on the activity of corticotropin-releasing hormone-expressing neurons in the hypothalamic paraventricular nucleus in male mice [PDF]

Translational Psychiatry
A variety of studies show the involvement of acid-sensing ion channel 1a (ASIC1a) in the modulation of stress, however, the precise underlying mechanisms remain unclear.
Jiayin Yue, Qilun Zhang, Mengyuan Wang, Xuelin Yao, Mengtian Wang, Ling Liu, Zhaohuan Huang, Yan Xing, Jinling Yan, Zihui Yan, Xing-Lei Song, Wei Wang   +11 more
doaj   +2 more sources

Blocking acid-sensing ion channel 1a attenuates bilirubin-induced ototoxicity in cochlear organotypic culture [PDF]

Fundamental Research
Neonatal hyperbilirubinemia leads to neural dysfunction, including sensorineural hearing loss. Our previous studies demonstrated that elevated bilirubin induced apoptotic pathway activation and led to cell malformation in spiral ganglion neurons of ...
Yazhi Xing, Jia Jia, Ling Zhang, Fei Sun, Zhengnong Chen, Dalian Ding, Di Qian, Jianning Zhang, Haibo Ye, Haibo Shi, Shankai Yin   +10 more
doaj   +2 more sources

Acid-sensing ion channel 1a contributes to the calcium/calmodulin-dependent ferroptosis and aggravates intervertebral disc degeneration [PDF]

Redox Report
Objectives Acid-sensing ion channel 1a (ASIC1a) functions as an extracellular acid sensor, with its activation frequently associated with age-related diseases.
Lu-Ping Zhou, Jia-Qi Wang, Liang Kang, Yan-Xiang Hou, Xu Yan, Chen-Hao Zhao, Chong-Yu Jia, Hua-Qing Zhang, Ren-Jie Zhang, Cai-Liang Shen   +9 more
doaj   +2 more sources

Lycocasine A, a Lycopodium Alkaloid from Lycopodiastrum casuarinoides and Its Acid-Sensing Ion Channel 1a Inhibitory Activity [PDF]

Molecules
A novel Lycopodium alkaloid, lycocasine A (1), and seven known Lycopodium alkaloids (2–8), were isolated from Lycopodiastrum casuarinoides. Their structures were determined through NMR, HRESIMS, and X-ray diffraction analysis.
Shuai Jiang, Wen-Yan Li, Bei-Bei Gao, Qin-Shi Zhao   +3 more
doaj   +2 more sources

The secreted protein PCYOX1L controls the surface expression of acid-sensing ion channel 1a. [PDF]

Sci Adv
The modulation of neurotransmitter receptor density is an important molecular mechanism underlying synaptic plasticity. Acid-sensing ion channel 1a (ASIC1a), a receptor for protons, plays an important role in synaptic transmission. In this study, we used high-resolution proteomic analysis to identify prenylcysteine oxidase 1 like (PCYOX1L) as a ...
Kuspiel S, Schilling M, Weiß F, Wiesehahn A, Strüver L, Schmalzing G, Wiemuth D, Gründer S.   +7 more
europepmc   +3 more sources

Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites. [PDF]

Acta Naturae, 2019
The proton-gated cationic channels belonging to the ASIC family are widely distributed in the central nervous system of vertebrates and play an important role in several physiological and pathological processes. ASIC1a are most sensitive to acidification of the external medium, which is the reason for the current interest in their function and ...
Tikhonov DB, Magazanik LG, Nagaeva EI.
europepmc   +4 more sources

Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels [PDF]

Biomolecules, 2020
Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions.
Qian Jiang, Andrew M. Peterson, Yuyang Chu, Xiaolan Yao, Xiang-ming Zha, Xiang-Ping Chu   +5 more
doaj   +2 more sources

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography. [PDF]

PLoS ONE, 2018
Acid sensing ion channels (ASICs) are proton-gated ion channels that are members of the degenerin/epithelial sodium channel superfamily and are expressed throughout central and peripheral nervous systems.
Nate Yoder, Eric Gouaux
doaj   +2 more sources

Commentary: Effects of acid-sensing ion channel-1A (ASIC1A) on cocaine-induced synaptic adaptations [PDF]

Frontiers in Physiology, 2023
Abbas Bader, Abdul Yousaf, Xiang-Ping Chu   +2 more
doaj   +2 more sources