Results 1 to 10 of about 108,706 (283)
Acid-Sensing Ion Channels in Zebrafish [PDF]
Animals, 2021 The ASICs, in mammals as in fish, control deviations from the physiological values of extracellular pH, and are involved in mechanoreception, nociception, or taste receptions. They are widely expressed in the central and peripheral nervous system.
Giuseppe Montalbano +7 more
doaj +5 more sources
Acid-Sensing Ion Channels in Glial Cells [PDF]
Membranes, 2022 Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells.
Victoria Cegielski +5 more
doaj +5 more sources
Acid-Sensing Ion Channels and Mechanosensation. [PDF]
Int J Mol Sci, 2021 Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium channel superfamily due to their sodium permeability. Predominantly expressed in the central nervous system, ASICs are involved in synaptic plasticity, learning/memory, and fear
Ruan N +5 more
europepmc +5 more sources
Acid-sensing ion channels in sensory signaling. [PDF]
Am J Physiol Renal Physiol, 2020 Acid-sensing ion channels (ASICs) are cation-permeable channels that in the periphery are primarily expressed in sensory neurons that innervate tissues and organs. Soon after the cloning of the ASIC subunits, almost 20 yr ago, investigators began to use genetically modified mice to assess the role of these channels in physiological processes.
Carattino MD, Montalbetti N.
europepmc +4 more sources
Gating mechanisms of acid-sensing ion channels. [PDF]
Nature, 2018 Acid-sensing ion channels (ASICs) are trimeric, proton-gated and sodium-selective members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout vertebrate central and peripheral nervous systems.
Yoder N, Yoshioka C, Gouaux E.
europepmc +5 more sources
Acid-Sensing Ion Channels and Pain [PDF]
Pharmaceuticals, 2010 Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis.
Qihai Gu, Lu-Yuan Lee
doaj +3 more sources
The role of acid sensing ion channels in the cardiovascular function [PDF]
Frontiers in Physiology, 2023 Acid Sensing Ion Channels (ASIC) are proton sensors involved in several physiological and pathophysiological functions including synaptic plasticity, sensory systems and nociception.
Omar López-Ramírez +1 more
doaj +2 more sources
Zinc Permeation Through Acid-Sensing Ion Channels [PDF]
CellsAcid-sensing ion channels (ASICs), activated under acidic conditions, play a critical role in ischemic brain injury, but the detailed mechanisms and signaling pathways remain unclear.
Xiang-Ping Chu +2 more
doaj +2 more sources
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? [PDF]
Frontiers in Cellular Neuroscience, 2021 Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango +3 more
doaj +2 more sources
ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain [PDF]
Molecular Pain, 2010 Background Acid-sensing ion channels (ASICs) have long been known to sense extracellular protons and contribute to sensory perception. Peripheral ASIC3 channels represent natural sensors of acidic and inflammatory pain.
Cao Hui +4 more
doaj +3 more sources