Results 21 to 30 of about 40,009 (268)
Zinc Permeation Through Acid-Sensing Ion Channels [PDF]
CellsAcid-sensing ion channels (ASICs), activated under acidic conditions, play a critical role in ischemic brain injury, but the detailed mechanisms and signaling pathways remain unclear.
Xiang-Ping Chu +2 more
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Acid-sensing ion channels in sensory signaling. [PDF]
Am J Physiol Renal Physiol, 2020 Acid-sensing ion channels (ASICs) are cation-permeable channels that in the periphery are primarily expressed in sensory neurons that innervate tissues and organs. Soon after the cloning of the ASIC subunits, almost 20 yr ago, investigators began to use genetically modified mice to assess the role of these channels in physiological processes.
Carattino MD, Montalbetti N.
europepmc +4 more sources
Gating mechanisms of acid-sensing ion channels. [PDF]
Nature, 2018 Acid-sensing ion channels (ASICs) are trimeric, proton-gated and sodium-selective members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout vertebrate central and peripheral nervous systems.
Yoder N, Yoshioka C, Gouaux E.
europepmc +5 more sources
Tumor Biology, 2017 Acid-sensing ion channels, a proton-gated cation channel, can be activated by low extracellular pH and involved in pathogenesis of some tumors such as glioma and breast cancer.
Yu Wu +5 more
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Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
Journal of Biomedical Science, 2018 Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system
Yuan-Ren Cheng +2 more
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Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution [PDF]
eLife, 2023 Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, the employment of specific LGICs ...
Josep Martí-Solans +4 more
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Acid-Sensing Ion Channels in Postoperative Pain [PDF]
The Journal of Neuroscience, 2011 Iatrogenic pain consecutive to a large number of surgical procedures has become a growing health concern. The etiology and pathophysiology of postoperative pain are still poorly understood, but hydrogen ions appear to be important in this process. We have investigated the role of peripheral acid-sensing ion channels (ASICs), which form depolarizing ...
Deval, Emmanuel +8 more
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The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity [PDF]
eLife, 2020 Acid-sensing ion channels (ASICs) are proton-gated members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout the central and peripheral nervous systems.
Nate Yoder, Eric Gouaux
doaj +2 more sources
Biomolecules, 2019 Acid-sensing ion channel (ASIC) channels belong to the family of ligand-gated ion channels known as acid-sensing (proton-gated) ion channels. Only a few activators of ASICs are known.
Dmitry I. Osmakov +4 more
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Peptides inhibitors of acid-sensing ion channels
Toxicon, 2007 Acid-sensing ion channels (ASICs) channels are proton-gated cationic channels mainly expressed in central and peripheric nervous system and related to the epithelial amiloride-sensitive Na(+) channels and to the degenerin family of ion channels. ASICs comprise four proteins forming functional channel subunits (ASIC1a, ASIC1b, ASIC2a, and ASIC3) and two
Diochot, S. +4 more
openaire +3 more sources