Results 21 to 30 of about 108,706 (283)

Hydrogen Sulfide, an Emerging Regulator of Acid-Sensing Ion Channels [PDF]

Function, 2021
Csaba Szabo
doaj   +2 more sources

Acid-sensing ion channels and migraine

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are activated by extracellular protons (H+), which belong to epithelial sodium channels/degenerin (ENaC/DEG) superfamily.
Yu-qi KANG, Zu-neng LU, Zhe-man XIAO
doaj   +1 more source

Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain. [PDF]

Curr Neuropharmacol, 2021
Storozhuk M, Cherninskyi A, Maximyuk O, Isaev D, Krishtal O.   +4 more
europepmc   +2 more sources

Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors. [PDF]

J Physiol, 2021
Rook ML, Musgaard M, MacLean DM.
europepmc   +2 more sources

Peripheral Inflammation Results in Increased Excitability of Capsaicin-Insensitive Nociceptive DRG Neurons Mediated by Upregulation of ASICs and Voltage-Gated Ion Channels

Frontiers in Cellular Neuroscience, 2021
Previously, we have characterized the capsaicin-insensitive low pH-sensitive (caps−lpH+) subtype of small-sized nociceptive dorsal root ganglion (DRG) neurons that express acid-sensing ion channels, T-type Ca2+ channels, and have isolectin B4-negative ...
Dmytro E. Duzhyy, Nana V. Voitenko, Nana V. Voitenko, Nana V. Voitenko, Pavel V. Belan, Pavel V. Belan   +5 more
doaj   +1 more source

Ion Channel Genes in Painful Neuropathies

Biomedicines, 2023
Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets.
Milena Ślęczkowska, Kaalindi Misra, Silvia Santoro, Monique M. Gerrits, Janneke G. J. Hoeijmakers   +4 more
doaj   +1 more source

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells

Toxins, 2023
Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family.
Ekaterina N. Lyukmanova, Maxim M. Zaigraev, Dmitrii S. Kulbatskii, Aizek B. Isaev, Ilya D. Kukushkin, Maxim L. Bychkov, Mikhail A. Shulepko, Anton O. Chugunov, Mikhail P. Kirpichnikov   +8 more
doaj   +1 more source

Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. [PDF]

PLoS ONE, 2013
It has been reported that both activation of N-methyl-D-aspartate receptors and acid-sensing ion channels during cerebral ischemic insult contributed to brain injury.
Kwok Keung Tai, Daniel D Truong
doaj   +1 more source

Voltage Sensing in Bacterial Protein Translocation [PDF]

, 2020
The bacterial channel SecYEG efficiently translocates both hydrophobic and hydrophilic proteins across the plasma membrane. Translocating polypeptide chains may dislodge the plug, a half helix that blocks the permeation of small molecules, from its ...
Bondar, Ana-Nicoleta, Knyazev, Denis G., Kuttner, Roland, Pohl, Peter, Siligan, Christine, Zimmerman, Mirjam   +5 more
core   +1 more source

A Role for Acid-sensing Ion Channel 3, but Not Acid-sensing Ion Channel 2, in Sensing Dynamic Mechanical Stimuli [PDF]

Anesthesiology, 2010
Background Acid-sensing ion channels 2 and 3 (ASIC2 and ASIC3, respectively) have been implicated as putative mechanotransducers. Because mechanical hyperalgesia is a prominent consequence of nerve injury, we tested whether male and female ASIC2 or ASIC3 knockout mice have altered responses to mechanical and heat ...
Jasenka, Borzan, Chengshui, Zhao, Richard A, Meyer, Srinivasa N, Raja   +3 more
openaire   +2 more sources