Results 41 to 50 of about 38,896 (239)
Acid-sensing ion channels in pain and disease [PDF]
Nature Reviews Neuroscience, 2013 Why do neurons sense extracellular acid? In large part, this question has driven increasing investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous system for the past two decades. Significant progress has been made in understanding the structure and function of ASICs at the molecular level.
John A, Wemmie +2 more
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Acid-sensing ion channels modulate bladder nociception.
Am J Physiol Renal Physiol, 2021 Our study indicates that protons and their cognate acid-sensing ion channel receptors are part of a mechanism that operates at bladder afferent terminals to control their function and that the loss of this regulatory mechanism results in hyperactivation of nociceptive pathways and the development of pain in the setting of chemical-induced cystitis.
Montalbetti N, Carattino MD.
europepmc +3 more sources
OPINION: History and Perspectives of ASICs
BBA Advances, 2023 The author recalls several particularly memorable events during his scientific career that led to the discovery of acid-sensing ion channels and ionotropic purinergic receptors.
Oleg Krishtal
doaj +1 more source
Novel Therapeutic Targets for Migraine
Biomedicines, 2023 Migraine, a primary headache disorder involving a dysfunctional trigeminal vascular system, remains a major debilitating neurological condition impacting many patients’ quality of life.
Areeba Nisar +2 more
doaj +1 more source
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
eLife, 2019 Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear.
Florian Ullrich +5 more
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Neurosensory mechanotransduction through acid‐sensing ion channels [PDF]
Journal of Cellular and Molecular Medicine, 2013 AbstractAcid‐sensing ion channels (ASICs) are voltage‐insensitive cation channels responding to extracellular acidification. ASIC proteins have two transmembrane domains and a large extracellular domain. The molecular topology of ASICs is similar to that of the mechanosensory abnormality 4‐ or 10‐proteins expressed in touch receptor neurons and ...
Chen, Chih-Cheng, Wong, Chia-Wen
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Biomolecules, 2019 Acid-sensing ion channel (ASIC) channels belong to the family of ligand-gated ion channels known as acid-sensing (proton-gated) ion channels. Only a few activators of ASICs are known.
Dmitry I. Osmakov +4 more
doaj +1 more source
Ion Selectivity in the Selectivity Filters of Acid-Sensing Ion Channels [PDF]
Scientific Reports, 2015 Sodium-selective acid sensing ion channels (ASICs), which belong to the epithelial sodium channel (ENaC) superfamily, are key players in many physiological processes (e.g. nociception, mechanosensation, cognition, and memory) and are potential therapeutic targets.
Todor Dudev, Carmay Lim
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses. [PDF]
Circ Res, 2019 Rationale: Precise regulation of cerebral blood flow is critical for normal brain function. Insufficient cerebral blood flow contributes to brain dysfunction and neurodegeneration. Carbon dioxide (CO 2 ), via effects on local acidosis, is one of the most potent regulators of cerebral ...
Faraci FM +5 more
europepmc +4 more sources