Results 51 to 60 of about 40,009 (268)

Plant-derived natural products targeting ion channels for pain

Neurobiology of Pain, 2023
Chronic pain affects approximately one-fifth of people worldwide and reduces quality of life and in some cases, working ability. Ion channels expressed along nociceptive pathways affect neuronal excitability and as a result modulate pain experience ...
Sachin Goyal, Shivali Goyal, Aleyah E. Goins, Sascha R.A. Alles   +3 more
doaj   +1 more source

The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis

Cell Death and Disease, 2022
Inflammation is one of the main pathological features leading to skin fibrosis and a key factor leading to the progression of skin fibrosis. Acidosis caused by a decrease in extracellular pH is a sign of the inflammatory process.
Jun-Jie Wu, Zi-Li Sun, Si-Yu Liu, Zhong-Hua Chen, Zheng-Dong Yuan, Ming-Li Zou, Ying-Ying Teng, Yue-Yue Li, Dan-Yang Guo, Feng-Lai Yuan   +9 more
doaj   +1 more source

Acid-Sensing Ion Channels Contribute to Neurotoxicity [PDF]

Translational Stroke Research, 2013
Acidosis that occurs under pathological conditions not only affects intracellular signaling molecules, but also directly activates a unique family of ligand-gated ion channels: acid-sensing ion channels (ASICs). ASICs are widely expressed throughout the central and peripheral nervous systems and play roles in pain sensation, learning and memory, and ...
Xiang-Ping, Chu, Kenneth A, Grasing, John Q, Wang   +2 more
openaire   +2 more sources

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review

Heliyon, 2023
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj   +1 more source

Pancreatic ductal bicarbonate secretion: challenge of the acinar acid load

Frontiers in Physiology, 2011
Acinar and ductal cells of the exocrine pancreas form a close functional unit. Although most studies contain data either on acinar or ductal cells, an increasing number of evidence highlights the importance of the pancreatic acinar-ductal functional unit.
Peter eHegyi, Jozsef eMaléth, Viktória eVenglovecz, Zoltan eRakonczay   +3 more
doaj   +1 more source

Acid-Sensing Ion Channel 2: Function and Modulation [PDF]

Membranes, 2022
Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family. Four genes encode at least six subunits, which combine to form a variety of homotrimers and heterotrimers.
Andy Sivils, Felix Yang, John Q. Wang, Xiang-Ping Chu   +3 more
openaire   +3 more sources

A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels

Marine Drugs, 2022
Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior, Rimma Kalina, Irina Gladkikh, Elena Leychenko, Jan Tytgat, Steve Peigneur   +5 more
doaj   +1 more source

The selectivity, voltage-dependence and acid sensitivity of the tandem pore potassium channel TASK-1 : contributions of the pore domains [PDF]

, 2007
We have investigated the contribution to ionic selectivity of residues in the selectivity filter and pore helices of the P1 and P2 domains in the acid sensitive potassium channel TASK-1.
Sutcliffe, M. J., M. J. Sutcliffe, Stanfield, P. R., Stanfield, Peter R., Stansfeld, P. J., Yuill, K. H., Ashmole, I., Yuill, K.H., Stansfeld, P.J., Stansfeld, Phillip J., I. Ashmole, P. J. Stansfeld, K. H. Yuill, P. R. Stanfield, Stanfield, P.R.   +14 more
core   +1 more source

Acid-sensing ion channel 3: An analgesic target [PDF]

Channels, 2021
Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation by extracellular protons mediate a transient inward current inducing cellular excitability.
Dulai, Jasdip Singh, Smith, Ewan St John, Rahman, Taufiq   +2 more
openaire   +2 more sources

Acid-Sensing Ion Channels in Pathological Conditions [PDF]

, 2012
Acid-sensing ion channels (ASICs), a novel family of proton-gated amiloride-sensitive cation channels, are expressed primarily in neurons of peripheral sensory and central nervous systems. Recent studies have shown that activation of ASICs, particularly the ASIC1a channels, plays a critical role in neuronal injury associated with neurological disorders
Xiang-Ping, Chu, Zhi-Gang, Xiong
openaire   +2 more sources