Results 51 to 60 of about 108,706 (283)
Acid-Sensing Ion Channels in Postoperative Pain [PDF]
The Journal of Neuroscience, 2011 Iatrogenic pain consecutive to a large number of surgical procedures has become a growing health concern. The etiology and pathophysiology of postoperative pain are still poorly understood, but hydrogen ions appear to be important in this process. We have investigated the role of peripheral acid-sensing ion channels (ASICs), which form depolarizing ...
Deval, Emmanuel +8 more
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Acid-sensing ion channel 3: An analgesic target [PDF]
Channels, 2021 Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation by extracellular protons mediate a transient inward current inducing cellular excitability.
Dulai, Jasdip Singh +2 more
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Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
Journal of Biomedical Science, 2018 Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system
Yuan-Ren Cheng +2 more
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Architectural and Functional Similarities between Trimeric ATP-Gated P2X Receptors and Acid-Sensing Ion Channels [PDF]
, 2015 ATP-gated P2X receptors and acid-sensing ion channels are two distinct ligand-gated ion channels that assemble into trimers. They are involved in many important physiological functions such as pain sensation and are recognized as important therapeutic ...
Grutter, T., Kellenberger, S.
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Acid-Sensing Ion Channels in Pathological Conditions [PDF]
, 2012 Acid-sensing ion channels (ASICs), a novel family of proton-gated amiloride-sensitive cation channels, are expressed primarily in neurons of peripheral sensory and central nervous systems. Recent studies have shown that activation of ASICs, particularly the ASIC1a channels, plays a critical role in neuronal injury associated with neurological disorders
Xiang-Ping, Chu, Zhi-Gang, Xiong
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Molecular basis for heat desensitization of TRPV1 ion channels. [PDF]
, 2019 The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows ...
Kamau, Peter Muiruri +8 more
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Novel Therapeutic Targets for Migraine
Biomedicines, 2023 Migraine, a primary headache disorder involving a dysfunctional trigeminal vascular system, remains a major debilitating neurological condition impacting many patients’ quality of life.
Areeba Nisar +2 more
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OPINION: History and Perspectives of ASICs
BBA Advances, 2023 The author recalls several particularly memorable events during his scientific career that led to the discovery of acid-sensing ion channels and ionotropic purinergic receptors.
Oleg Krishtal
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Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
eLife, 2019 Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear.
Florian Ullrich +5 more
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Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. [PDF]
, 2016 Electrical membrane properties of skeletal muscle fibers have been thoroughly studied over the last five to six decades. This has shown that muscle fibers from a wide range of species, including fish, amphibians, reptiles, birds, and mammals, are all ...
Chen, Tsung-Yu +4 more
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