Results 31 to 40 of about 38,896 (239)
Acid-Sensing Ion Channel 2: Function and Modulation [PDF]
Membranes, 2022 Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family. Four genes encode at least six subunits, which combine to form a variety of homotrimers and heterotrimers.
Andy Sivils +3 more
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Cell Death and Disease, 2022 Inflammation is one of the main pathological features leading to skin fibrosis and a key factor leading to the progression of skin fibrosis. Acidosis caused by a decrease in extracellular pH is a sign of the inflammatory process.
Jun-Jie Wu +9 more
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Acid-Sensing Ion Channels Contribute to Neurotoxicity [PDF]
Translational Stroke Research, 2013 Acidosis that occurs under pathological conditions not only affects intracellular signaling molecules, but also directly activates a unique family of ligand-gated ion channels: acid-sensing ion channels (ASICs). ASICs are widely expressed throughout the central and peripheral nervous systems and play roles in pain sensation, learning and memory, and ...
Xiang-Ping, Chu +2 more
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Heliyon, 2023 Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
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Acid-Sensing Ion Channels in Postoperative Pain [PDF]
The Journal of Neuroscience, 2011 Iatrogenic pain consecutive to a large number of surgical procedures has become a growing health concern. The etiology and pathophysiology of postoperative pain are still poorly understood, but hydrogen ions appear to be important in this process. We have investigated the role of peripheral acid-sensing ion channels (ASICs), which form depolarizing ...
Deval, Emmanuel +8 more
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Pancreatic ductal bicarbonate secretion: challenge of the acinar acid load
Frontiers in Physiology, 2011 Acinar and ductal cells of the exocrine pancreas form a close functional unit. Although most studies contain data either on acinar or ductal cells, an increasing number of evidence highlights the importance of the pancreatic acinar-ductal functional unit.
Peter eHegyi +3 more
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Marine Drugs, 2022 Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior +5 more
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Acid-sensing ion channel 3: An analgesic target [PDF]
Channels, 2021 Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation by extracellular protons mediate a transient inward current inducing cellular excitability.
Dulai, Jasdip Singh +2 more
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Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing
Journal of Biomedical Science, 2018 Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system
Yuan-Ren Cheng +2 more
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Acid-Sensing Ion Channels in Pathological Conditions [PDF]
, 2012 Acid-sensing ion channels (ASICs), a novel family of proton-gated amiloride-sensitive cation channels, are expressed primarily in neurons of peripheral sensory and central nervous systems. Recent studies have shown that activation of ASICs, particularly the ASIC1a channels, plays a critical role in neuronal injury associated with neurological disorders
Xiang-Ping, Chu, Zhi-Gang, Xiong
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