Results 31 to 40 of about 40,009 (268)

Hydrogen Sulfide, an Emerging Regulator of Acid-Sensing Ion Channels [PDF]

Function, 2021
Csaba Szabo
doaj   +2 more sources

Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation [PDF]

Mediators of Inflammation, 2017
Acid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride. Derived from 5 genes (ACCN1–5), 7 subunits have been identified,
Audrey Ortega-Ramírez, Rosario Vega, Enrique Soto   +2 more
doaj   +2 more sources

Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain. [PDF]

Curr Neuropharmacol, 2021
Storozhuk M, Cherninskyi A, Maximyuk O, Isaev D, Krishtal O.   +4 more
europepmc   +2 more sources

Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors. [PDF]

J Physiol, 2021
Rook ML, Musgaard M, MacLean DM.
europepmc   +2 more sources

Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock. [PDF]

Elife, 2022
Biological clocks are fundamental to an organism's health, controlling periodicity of behaviour and metabolism. Here, we identify two acid-sensing ion channels, with very different proton sensing properties, and describe their role in an ultradian clock,
Kaulich E, Carroll T, Ackley BD, Tang YQ, Hardege I, Nehrke K, Schafer WR, Walker DS.   +7 more
europepmc   +2 more sources

Voltage-clamp fluorometry for advancing mechanistic understanding of ion channel mechanisms with a focus on acid-sensing ion channels. [PDF]

Biochem Soc Trans
Voltage-clamp fluorometry (VCF) has revolutionized the study of ion channels by combining electrophysiology with fluorescence spectroscopy. VCF allows ion channel researchers to link dynamic structural changes, measured in real time, to function.
Centonze E, Kellenberger S.
europepmc   +2 more sources

Activating Acid-Sensing Ion Channels with Photoacid Generators. [PDF]

ChemPhotoChem, 2020
Acid-sensing ion channels (ASICs), present in both central and peripheral neurons, respond to changes in extracellular protons. They play important roles in many symptoms and diseases, such as pain, ischemic stroke and neurodegenerative diseases. Herein,
Liu X, Sambath K, Hutnik L, Du J, Belfield KD, Zhang Y.   +5 more
europepmc   +2 more sources

Peripheral Inflammation Results in Increased Excitability of Capsaicin-Insensitive Nociceptive DRG Neurons Mediated by Upregulation of ASICs and Voltage-Gated Ion Channels

Frontiers in Cellular Neuroscience, 2021
Previously, we have characterized the capsaicin-insensitive low pH-sensitive (caps−lpH+) subtype of small-sized nociceptive dorsal root ganglion (DRG) neurons that express acid-sensing ion channels, T-type Ca2+ channels, and have isolectin B4-negative ...
Dmytro E. Duzhyy, Nana V. Voitenko, Nana V. Voitenko, Nana V. Voitenko, Pavel V. Belan, Pavel V. Belan   +5 more
doaj   +1 more source

Determinants of ion selectivity in ASIC1a- and ASIC2a-containing acid-sensing ion channels. [PDF]

J Gen Physiol, 2020
Trimeric acid-sensing ion channels (ASICs) contribute to neuronal signaling by converting extracellular acidification into excitatory sodium currents. Previous work with homomeric ASIC1a implicates conserved leucine (L7') and consecutive glycine-alanine ...
Lynagh T, Flood E, Boiteux C, Sheikh ZP, Allen TW, Pless SA.   +5 more
europepmc   +3 more sources

Ion Channel Genes in Painful Neuropathies

Biomedicines, 2023
Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets.
Milena Ślęczkowska, Kaalindi Misra, Silvia Santoro, Monique M. Gerrits, Janneke G. J. Hoeijmakers   +4 more
doaj   +1 more source