Results 31 to 40 of about 108,706 (283)

Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. [PDF]

PLoS ONE, 2011
Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (
Xuanmao Chen, Paul Whissell, Beverley A Orser, John F MacDonald   +3 more
doaj   +1 more source

Acid-sensing ion channels under hypoxia [PDF]

Channels, 2013
Hypoxia represents the lack of oxygen below the basic level, and the range of known channels related to hypoxia is continually increasing. Since abnormal hypoxia initiates pathological processes in numerous diseases via, to a great degree, producing acidic microenvironment, the significance of these channels in this environment has, until now, remained
Guo, Yingjun, Qu, Xun
openaire   +2 more sources

Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neurons in vitro

Frontiers in Neurology, 2019
Objectives: Despite the long-term efficacy of antiepileptic drug treatments, frequent attacks of drug-resistant epilepsy necessitate the development of new antiepileptic drug therapy targets.
Fei Zhu, Fei Zhu, Fei Zhu, Fei Zhu, Wei Shan, Wei Shan, Wei Shan, Wei Shan, Qinlan Xu, Qinlan Xu, Qinlan Xu, Anchen Guo, Anchen Guo, Jianping Wu, Jianping Wu, Jianping Wu, Qun Wang, Qun Wang, Qun Wang   +18 more
doaj   +1 more source

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD, Dickenson, AH, Foulkes, T, Gerke, V, Lane, T, Matthews, EA, Nassar, MA, Okuse, K, Wood, JN   +8 more
core   +1 more source

Acid-sensing ion channels: trafficking and pathophysiology [PDF]

Channels, 2014
Acid-sensing ion channels (ASICs) are proton-gated cation channels that are widely expressed in both the peripheral and central nervous systems. ASICs contribute to a variety of pathophysiological conditions that involve tissue acidosis, such as ischemic stroke, epileptic seizures and multiple sclerosis.
Wei-Zheng, Zeng, Di-Shi, Liu, Tian-Le, Xu   +2 more
openaire   +2 more sources

Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice [PDF]

, 2014
Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also ...
Colettis, Natalia Claudia, Gonzalez, Laura Elisabeth, González Inchauspe, Carlota María Fabiola, Lino, Noelia Gisele, Uchitel, Osvaldo Daniel, Urbano Suarez, Francisco Jose, Vattino, Lucas Gabriel, Wemmie, John A., Wunsch, Amanda M.   +8 more
core   +1 more source

Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse [PDF]

, 2017
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be activated in neurons of the medial nucleus of the trapezoid body (MNTB) of the auditory system in ...
Di Guilmi, Mariano Nicolás, González Inchauspe, Carlota María Fabiola, Uchitel, Osvaldo Daniel, Urbano Suarez, Francisco Jose   +3 more
core   +1 more source

Acid-sensing Ion Channels in Malignant Gliomas [PDF]

Journal of Biological Chemistry, 2003
High grade glioma cells derived from patient biopsies express an amiloride-sensitive sodium conductance that has properties attributed to the human brain sodium channel family, also known as acid-sensing ion channels (ASICs). This amiloride-sensitive conductance was not detected in cells obtained from normal brain tissue or low grade or benign tumors ...
Bakhrom K, Berdiev, Jiazeng, Xia, Lee Anne, McLean, James M, Markert, G Yancey, Gillespie, Timothy B, Mapstone, Anjaparavanda P, Naren, Biljana, Jovov, James K, Bubien, Hong-Long, Ji, Catherine M, Fuller, Kevin L, Kirk, Dale J, Benos   +12 more
openaire   +2 more sources

Hypoxic regulation of ion channel function and expression [PDF]

, 2002
Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core   +1 more source

Acid-Sensing Ion Channel 2: Function and Modulation [PDF]

Membranes, 2022
Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family. Four genes encode at least six subunits, which combine to form a variety of homotrimers and heterotrimers.
Andy Sivils, Felix Yang, John Q. Wang, Xiang-Ping Chu   +3 more
openaire   +3 more sources