Results 11 to 20 of about 38,896 (239)

Acid-Sensing Ion Channels and Mechanosensation [PDF]

International Journal of Molecular Sciences, 2021
Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium channel superfamily due to their sodium permeability. Predominantly expressed in the central nervous system, ASICs are involved in synaptic plasticity, learning/memory, and fear
Andrew Peterson, Chu Xp, John Wang
exaly   +5 more sources

Acid-sensing ion channels in sensory signaling [PDF]

American Journal of Physiology - Renal Physiology, 2020
Acid-sensing ion channels (ASICs) are cation-permeable channels that in the periphery are primarily expressed in sensory neurons that innervate tissues and organs. Soon after the cloning of the ASIC subunits, almost 20 yr ago, investigators began to use genetically modified mice to assess the role of these channels in physiological processes.
Marcelo Carattino, Nicolas Montalbetti
exaly   +4 more sources

Gating mechanisms of acid-sensing ion channels [PDF]

Nature, 2018
Acid-sensing ion channels (ASICs) are trimeric, proton-gated and sodium-selective members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout vertebrate central and peripheral nervous systems.
Craig Yoshioka, Eric Gouaux, Nathan Yoder   +2 more
exaly   +5 more sources

Modulation of Neurotransmission by Acid-Sensing Ion Channels

Journal of Physiological Investigation
Interstitial pH fluctuations occur normally in the brain and significantly modulate neuronal functions. Acid-sensing ion channels (ASICs), which serve as neuronal acid chemosensors, play important roles in synaptic plasticity, learning, and memory ...
Pu-Yeh Wu, Cheng-Chang Lien
doaj   +3 more sources

Acid-sensing ion channels: trafficking and synaptic function [PDF]

Molecular Brain, 2013
Extracellular acidification occurs in the brain with elevated neural activity, increased metabolism, and neuronal injury. This reduction in pH can have profound effects on brain function because pH regulates essentially every single biochemical reaction.
Zha Xiang-ming
doaj   +3 more sources

Hydrogen Sulfide, an Emerging Regulator of Acid-Sensing Ion Channels [PDF]

Function, 2021
Csaba Szabo
doaj   +2 more sources

Acid-sensing ion channels and migraine

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are activated by extracellular protons (H+), which belong to epithelial sodium channels/degenerin (ENaC/DEG) superfamily.
Yu-qi KANG, Zu-neng LU, Zhe-man XIAO
doaj   +1 more source

Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain [PDF]

Current Neuropharmacology, 2021
Maksim Storozhuk, Dmytro Isaev, Oleksandr Maximyuk   +2 more
exaly   +2 more sources

Cholestane-3β,5α,6β-Triol Inhibits Acid-Sensing Ion Channels and Reduces Acidosis-Mediated Ischemic Brain Injury [PDF]

Stroke
Zhigang Xiong, Tiandong Leng, Huawei Sun   +2 more
exaly   +2 more sources

Peripheral Inflammation Results in Increased Excitability of Capsaicin-Insensitive Nociceptive DRG Neurons Mediated by Upregulation of ASICs and Voltage-Gated Ion Channels

Frontiers in Cellular Neuroscience, 2021
Previously, we have characterized the capsaicin-insensitive low pH-sensitive (caps−lpH+) subtype of small-sized nociceptive dorsal root ganglion (DRG) neurons that express acid-sensing ion channels, T-type Ca2+ channels, and have isolectin B4-negative ...
Dmytro E. Duzhyy, Nana V. Voitenko, Nana V. Voitenko, Nana V. Voitenko, Pavel V. Belan, Pavel V. Belan   +5 more
doaj   +1 more source