Results 11 to 20 of about 108,706 (283)
Tumor Biology, 2017 Acid-sensing ion channels, a proton-gated cation channel, can be activated by low extracellular pH and involved in pathogenesis of some tumors such as glioma and breast cancer.
Yu Wu +5 more
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Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution [PDF]
eLife, 2023 Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, the employment of specific LGICs ...
Josep Martí-Solans +4 more
doaj +2 more sources
The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity [PDF]
eLife, 2020 Acid-sensing ion channels (ASICs) are proton-gated members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout the central and peripheral nervous systems.
Nate Yoder, Eric Gouaux
doaj +2 more sources
Basics on the use of acid-sensing ion channels’ inhibitors as therapeutics
Neural Regeneration Research, 2019 Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases
Jamileh Dibas +2 more
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Acid-sensing ion channels: trafficking and synaptic function [PDF]
Molecular Brain, 2013 Extracellular acidification occurs in the brain with elevated neural activity, increased metabolism, and neuronal injury. This reduction in pH can have profound effects on brain function because pH regulates essentially every single biochemical reaction.
Zha Xiang-ming
doaj +3 more sources
Modulation of Neurotransmission by Acid-Sensing Ion Channels
Journal of Physiological InvestigationInterstitial pH fluctuations occur normally in the brain and significantly modulate neuronal functions. Acid-sensing ion channels (ASICs), which serve as neuronal acid chemosensors, play important roles in synaptic plasticity, learning, and memory ...
Pu-Yeh Wu, Cheng-Chang Lien
doaj +3 more sources
Acid-sensing ion channels in pain and disease [PDF]
Nature Reviews Neuroscience, 2013 Why do neurons sense extracellular acid? In large part, this question has driven increasing investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous system for the past two decades. Significant progress has been made in understanding the structure and function of ASICs at the molecular level.
John A Wemmie, Rebecca J Taugher
exaly +3 more sources
Acid-sensing ion channels modulate bladder nociception.
Am J Physiol Renal Physiol, 2021 Our study indicates that protons and their cognate acid-sensing ion channel receptors are part of a mechanism that operates at bladder afferent terminals to control their function and that the loss of this regulatory mechanism results in hyperactivation of nociceptive pathways and the development of pain in the setting of chemical-induced cystitis.
Montalbetti N, Carattino MD.
europepmc +3 more sources
Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses. [PDF]
Circ Res, 2019 Rationale: Precise regulation of cerebral blood flow is critical for normal brain function. Insufficient cerebral blood flow contributes to brain dysfunction and neurodegeneration. Carbon dioxide (CO 2 ), via effects on local acidosis, is one of the most potent regulators of cerebral ...
Faraci FM +5 more
europepmc +4 more sources
Acid-sensing ion channels in gastrointestinal function
Neuropharmacology, 2015 Gastric acid is of paramount importance for digestion and protection from pathogens but, at the same time, is a threat to the integrity of the mucosa in the upper gastrointestinal tract and may give rise to pain if inflammation or ulceration ensues.
Peter Holzer
exaly +3 more sources