Results 11 to 20 of about 40,009 (268)
Acid-Sensing Ion Channels in Glial Cells [PDF]
Membranes, 2022 Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells.
Victoria Cegielski +5 more
doaj +6 more sources
Acid-Sensing Ion Channels and Mechanosensation. [PDF]
Int J Mol Sci, 2021 Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium channel superfamily due to their sodium permeability. Predominantly expressed in the central nervous system, ASICs are involved in synaptic plasticity, learning/memory, and fear
Ruan N +5 more
europepmc +6 more sources
Acid-Sensing Ion Channels in Zebrafish [PDF]
Animals, 2021 The ASICs, in mammals as in fish, control deviations from the physiological values of extracellular pH, and are involved in mechanoreception, nociception, or taste receptions. They are widely expressed in the central and peripheral nervous system.
Giuseppe Montalbano +7 more
doaj +5 more sources
Acid-Sensing Ion Channels and Pain [PDF]
Pharmaceuticals, 2010 Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis.
Qihai Gu, Lu-Yuan Lee
doaj +4 more sources
Basics on the use of acid-sensing ion channels’ inhibitors as therapeutics
Neural Regeneration Research, 2019 Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases
Jamileh Dibas +2 more
doaj +3 more sources
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? [PDF]
Frontiers in Cellular Neuroscience, 2021 Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango +3 more
doaj +4 more sources
Modulation of Neurotransmission by Acid-Sensing Ion Channels
Journal of Physiological InvestigationInterstitial pH fluctuations occur normally in the brain and significantly modulate neuronal functions. Acid-sensing ion channels (ASICs), which serve as neuronal acid chemosensors, play important roles in synaptic plasticity, learning, and memory ...
Pu-Yeh Wu, Cheng-Chang Lien
doaj +4 more sources
Acid-sensing ion channels: trafficking and synaptic function [PDF]
Molecular Brain, 2013 Extracellular acidification occurs in the brain with elevated neural activity, increased metabolism, and neuronal injury. This reduction in pH can have profound effects on brain function because pH regulates essentially every single biochemical reaction.
Zha Xiang-ming
doaj +5 more sources
Acid-sensing ion channels and migraine
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are activated by extracellular protons (H+), which belong to epithelial sodium channels/degenerin (ENaC/DEG) superfamily.
Yu-qi KANG, Zu-neng LU, Zhe-man XIAO
doaj +2 more sources
The role of acid sensing ion channels in the cardiovascular function [PDF]
Frontiers in Physiology, 2023 Acid Sensing Ion Channels (ASIC) are proton sensors involved in several physiological and pathophysiological functions including synaptic plasticity, sensory systems and nociception.
Omar López-Ramírez +1 more
doaj +2 more sources