Results 71 to 80 of about 40,009 (268)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structure and activity of the acid-sensing ion channels
American Journal of Physiology-Cell Physiology, 2012 The acid-sensing ion channels (ASICs) are a family of proton-sensing channels expressed throughout the nervous system. Their activity is linked to a variety of complex behaviors including fear, anxiety, pain, depression, learning, and memory. ASICs have also been implicated in neuronal degeneration accompanying ischemia and multiple sclerosis.
Thomas W, Sherwood +2 more
openaire +3 more sources
Acid-sensing ion channels and transient-receptor potential ion channels in zebrafish taste buds
, 2016 Sensory information from the environment is required for life and survival, and it is detected by specialized cells which togethermakeup the sensory system.
Germanà, A. +15 more
core +2 more sources
Proton Sensing on the Ocular Surface: Implications in Eye Pain
Frontiers in Pharmacology, 2021 Protons reaching the eyeball from exogenous acidic substances or released from damaged cells during inflammation, immune cells, after tissue injury or during chronic ophthalmic conditions, activate or modulate ion channels present in sensory nerve fibers
Núria Comes +5 more
doaj +1 more source
Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses. [PDF]
Circ Res, 2019 Rationale: Precise regulation of cerebral blood flow is critical for normal brain function. Insufficient cerebral blood flow contributes to brain dysfunction and neurodegeneration. Carbon dioxide (CO 2 ), via effects on local acidosis, is one of the most potent regulators of cerebral ...
Faraci FM +5 more
europepmc +4 more sources
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Ion Selectivity in the Selectivity Filters of Acid-Sensing Ion Channels [PDF]
Scientific Reports, 2015 Sodium-selective acid sensing ion channels (ASICs), which belong to the epithelial sodium channel (ENaC) superfamily, are key players in many physiological processes (e.g. nociception, mechanosensation, cognition, and memory) and are potential therapeutic targets.
Todor Dudev, Carmay Lim
openaire +2 more sources
, 2011 PURPOSE: We examined the possible role of H(+) activated acid-sensing ion channels in pain perception. We characterized expression in bladder dome biopsies from patients with bladder pain syndrome and controls, in cultured human urothelium and in ...
Kessler, T.M. +23 more
core +1 more source
Molecular Pain, 2010 Background Acid-sensing ion channels (ASICs) have long been known to sense extracellular protons and contribute to sensory perception. Peripheral ASIC3 channels represent natural sensors of acidic and inflammatory pain.
Cao Hui +4 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source