Results 91 to 100 of about 108,706 (283)

An acid-sensing ion channel that detects ischemic pain [PDF]

Brazilian Journal of Medical and Biological Research, 2005
Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The pain of a heart attack is the prototypical example. Multiple compounds released from ischemic muscle likely contribute to this pain by acting on sensory neurons that innervate muscle. One such compound is lactic acid.
Naves, L.A., McCleskey, E.W.
openaire   +5 more sources

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Photo-responsive polymeric structures based on spiropyran [PDF]

, 2012
Spiropyrans are one of the most popular classes of photochromic compounds that change their optical and structural properties in response to external inputs such as light, protons and metal ions, making them ideal molecules for the fabrication of ...
Adelmann, Alonso, Anastasiadis, Angiolini, Bardavid, Bassetti, Beebe, Beiermann, Beiermann, Bell, Benito-Lopez, Benito-Lopez, Berkovic, Byrne, Byrne, Byrne, Byrne, Byrne, Cheng, Chung, Coleman, Coleman, Connal, Darwish, Dattilo, Davis, Delaire, Dong, Doron, Dürr, Fischer, Florea, Florea, Fries, Fries, Fries, Garcia, Guo, Higuchi, Hirshberg, Imai, Irie, Ivanov, Joseph, Kimura, Kobayashi, Kotharangannagari, Kwon, LaVan, Lee, Lee, Lee, Lee, Levy, Li, Lin, Lygeraki, Minkin, Natali, O'Bryan, Park, Park, Pennakalathil, Piech, Radu, Richter, Rosario, Rosario, Sakai, Samanta, Samoladas, Saragi, Satoh, Shiraishi, Shiraishi, Stauffer, Stitzel, Such, Sugiura, Suzuki, Tachibana, Wang, Zhao   +82 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. [PDF]

PLoS ONE, 2018
Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to ventilatory drive in conscious, unrestrained animals remain largely unknown.
Neil D Detweiler, Kenneth G Vigil, Thomas C Resta, Benjimen R Walker, Nikki L Jernigan   +4 more
doaj   +1 more source

Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating. [PDF]

, 2017
Acid-sensing ion channels (ASICs) are proton-activated Na ⁺ channels expressed in the nervous system, where they are involved in learning, fear behaviors, neurodegeneration, and pain sensation. In this work, we study the role in pH
Bernèche, S., Bonifacio, G., Johner, N., Kellenberger, S., Roy, S., Vullo, S.   +5 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3

Nature Communications, 2018
Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca2+ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates ...
Zhicheng Zuo, Rachel N. Smith, Zhenglan Chen, Amruta S. Agharkar, Heather D. Snell, Renqi Huang, Jin Liu, Eric B. Gonzales   +7 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

CO2-dependent opening of an inwardly rectifying K+ channel [PDF]

, 2011
CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Huckstepp, Robert T. R., Dale, Nicholas
core   +1 more source