Results 91 to 100 of about 40,009 (268)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
, 2006 Ion channels are one of the main drug targets and are in the focus of various membrane biosensor applications and drug screening assays. The aim of this thesis was to develop and characterize a novel membrane system suspending highly ordered porous ...
Römer, Winfried
core +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3
Nature Communications, 2018 Acid-sensing ion channels (ASICs) sense changes in extracellular acidity with Ca2+ as an allosteric modulator and channel blocker. Here authors use electrophysiology and molecular dynamics simulation to identify the residue in ASIC3 which modulates ...
Zhicheng Zuo +7 more
doaj +1 more source
Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses. [PDF]
PLoS ONE, 2018 Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to ventilatory drive in conscious, unrestrained animals remain largely unknown.
Neil D Detweiler +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Layer-by-layer assembly of organic films and their application to multichannel surface plasmon resonance sensing [PDF]
, 2004 This thesis provides a study of a single chip, multi-channel surface plasmon resonance (SPR) imaging system. The equipment has no moving parts and uses a single sensor "chip" onto which multiple channels can be incorporated.
Palumbo, Marco, Marco Palumbo, Dott
core
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
An acid-sensing ion channel that detects ischemic pain [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The pain of a heart attack is the prototypical example. Multiple compounds released from ischemic muscle likely contribute to this pain by acting on sensory neurons that innervate muscle. One such compound is lactic acid.
Naves, L.A., McCleskey, E.W.
openaire +5 more sources
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain [PDF]
, 2011 Coral snake's potent toxin identifiedThe bite of the Texas coral snake, although not fatal, causes excruciating and long-lasting pain. The toxin involved has now been characterized.
Allan I. Basbaum +19 more
core +1 more source