Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention [PDF]
Cell Death Discovery, 2023 Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues ...
Zhenyu Zhang +10 more
doaj +2 more sources
Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. [PDF]
PLoS ONE, 2016 Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR.
Leah R Reznikov +9 more
doaj +4 more sources
Commentary: Potential Therapeutic Consequences of an Acid-Sensing Ion Channel 1a-Blocking Antibody [PDF]
Frontiers in Pharmacology, 2019 Andrew Peterson +3 more
doaj +5 more sources
Smooth muscle Acid-sensing ion channel 1a as a therapeutic target to reverse hypoxic pulmonary hypertension [PDF]
Frontiers in Molecular Biosciences, 2022 Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that conducts both Na+ and Ca2+. Activation of ASIC1a elicits plasma membrane depolarization and stimulates intracellular Ca2+-dependent signaling pathways in ...
Selina M. Garcia +7 more
doaj +2 more sources
Acid-Sensing Ion Channel 1a Contributes to the Prefrontal Cortex Ischemia-Enhanced Neuronal Activities in the Amygdala [PDF]
Brain Sciences, 2023 Following a stroke, the emergence of amygdala-related disorders poses a significant challenge, with severe implications for post-stroke mental health, including conditions such as anxiety and depression.
Gyeongah Park +3 more
doaj +2 more sources
Selective blockade of acid-sensing ion channel 1a can provide substantial hippocampal neuroprotection [PDF]
Frontiers in Cell and Developmental BiologyBackgroundAcid-sensing ion channel 1a (ASIC1a) is the only member of the ASIC family where Ca2+ osmosis has been reported, and it is highly expressed in neurons of the central nervous system.
Jiaai Li +7 more
doaj +2 more sources
Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance The response from every type of neurotransmitter-gated ion channel (NGIC) decays within a proscribed time when its agonist is removed. NGICs that decay faster are more involved in higher frequency signals, whereas slower channels promote cell excitability and plasticity.
David Maclean +2 more
exaly +3 more sources
Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a [PDF]
Cell Death and Disease, 2022 Eliciting regulated cell death, like necroptosis, is a potential cancer treatment. However, pathways eliciting necroptosis are poorly understood. It has been reported that prolonged activation of acid-sensing ion channel 1a (ASIC1a) induces necroptosis ...
Jan Clusmann +9 more
doaj +2 more sources
Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1 [PDF]
eLife, 2020 Acid-sensing ion channels (ASICs) are proton-gated cation channels that are involved in diverse neuronal processes including pain sensing. The peptide toxin Mambalgin1 (Mamba1) from black mamba snake venom can reversibly inhibit the conductance of ASICs,
Demeng Sun +13 more
doaj +2 more sources
Acid-sensing ion channel 1a deficiency drives endocrine hypertension in male mice. [PDF]
J PhysiolAbstract Acid‐sensing ion channel 1a (ASIC1a) is a proton‐gated cation channel activated by extracellular acidosis, a condition often associated with ischaemia, inflammation and metabolic stress.
Garcia SM +9 more
europepmc +4 more sources