Results 81 to 90 of about 2,309 (187)
Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation. [PDF]
PLoS ONE, 2013 Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel that contributes to fear and pain as well as neuronal damage following persistent cerebral acidosis.
Erin N Frey +4 more
doaj +1 more source
ASIC1a activation by amitriptyline and FMRF-amide is removed by serine proteases [PDF]
Channels, 2008 Analgesia induced by certain tricyclic antidepressants has been largely used for decades, yet the mechanisms involved are incompletely understood. Starting from previously reported dual effects of amitriptyline on wild-type ENaC (Pena F, et al. J Pharm Pharmacol 54:1393-8: 2002), we extended our study to ASIC1a by performing a series of whole cell and ...
Adela N, Marin +4 more
openaire +2 more sources
Epilepsy: Molecular Pathogenesis and Emerging Therapies
MedComm, Volume 7, Issue 4, April 2026.Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Wanbin Huang +5 more
wiley +1 more source
Molecular basis of inhibition of acid sensing ion channel 1A by diminazene. [PDF]
PLoS ONE, 2018 Acid-sensing ion channels (ASICs) are trimeric proton-gated cation permeable ion channels expressed primarily in neurons. Here we employed site-directed mutagenesis and electrophysiology to investigate the mechanism of inhibition of ASIC1a by diminazene.
Aram J Krauson +2 more
doaj +1 more source
PLoS Computational Biology, 2023 Dorsal horn of the spinal cord is an important crossroad of pain neuraxis, especially for the neuronal plasticity mechanisms that can lead to chronic pain states. Windup is a well-known spinal pain facilitation process initially described several decades
Magda Chafaï +9 more
doaj +1 more source
Independent Contribution of Extracellular Proton Binding Sites to ASIC1a Activation [PDF]
Journal of Biological Chemistry, 2013 Acid-sensing ion channels (ASICs) are a group of trimeric cation permeable channels gated by extracellular protons that are mainly expressed in the nervous system. Despite the structural information available for ASIC1, there is limited understanding of the molecular mechanism that allows these channels to sense and respond to drops in extracellular pH.
Aram J, Krauson +2 more
openaire +2 more sources
Acta Physiologica, Volume 242, Issue 3, March 2026.ABSTRACT Aim Controversy exists on which metabolites determine the exaggerated exercise pressor reflex (EPR) in peripheral artery disease (PAD). In decerebrated rats, we investigated the role played by lactate and hydrogen ions in a model of PAD, which was simulated by ligating the femoral artery for 72 h before the start of the experiment.
Guillaume P. Ducrocq +3 more
wiley +1 more source
Physiological Reports, Volume 14, Issue 5, March 2026.Abstract Cardiac afferent neurons have been shown to trigger overactivation of neurohormonal systems known to drive adverse cardiac remodeling following myocardial infarction (MI). Acid‐sensing ion channels (ASICs) that are highly expressed in cardiac sympathetic afferents sense ischemia‐induced myocardial acidosis.
Karley M. Monaghan +14 more
wiley +1 more source
NMDAR-Mediated Hippocampal Neuronal Death is Exacerbated by Activities of ASIC1a [PDF]
Neurotoxicity Research, 2015 NMDARs and ASIC1a both exist in central synapses and mediate important physiological and pathological conditions, but the functional relationship between them is unclear. Here we report several novel findings that may shed light on the functional relationship between these two ion channels in the excitatory postsynaptic membrane of mouse hippocampus ...
Su, Gao +9 more
openaire +2 more sources
Coexpression of ASIC2a with ASIC1a generates increased currents.
, 2014 A, Representative acid-evoked currents generated by pH 4 application to CHO cells transfected with the indicated ASIC subunits. Coexpressed ASICs were expressed at half the normal amount to keep total ASIC cDNA constant.
Mamta Gautam (327051) +4 more
core +1 more source