Results 81 to 90 of about 1,823 (155)
Nature Communications, 2016 The acid-sensing ion channel, ASIC1a, is known to play a role in synaptic transmission and plasticity. Here, the authors demonstrate a role for ASIC1a in regulating plasticity in the insular cortex and find that extinction of conditioned taste aversion ...
Wei-Guang Li +11 more
doaj +1 more source
Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties
Toxins, 2019 Acid-sensing ion channels (ASICs), which are present in almost all types of neurons, play an important role in physiological and pathological processes. The ASIC1a subtype is the most sensitive channel to the medium’s acidification, and it plays an
Dmitry I. Osmakov +7 more
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International Journal of Rheumatic Diseases, Volume 28, Issue 10, October 2025.ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic synovitis and skeletal joint deformities, often accompanied by systemic symptoms. Over the past few decades, various susceptibility factors for RA have been revealed, and numerous therapeutic drugs have been developed, including analgesics, glucocorticoids ...
Xiaorong Zhi +5 more
wiley +1 more source
Identification of the modulatory Ca2+-binding sites of acid-sensing ion channel 1a
Open BiologyAcid-sensing ion channels (ASICs) are neuronal Na+-permeable ion channels activated by extracellular acidification. ASICs are involved in learning, fear sensing, pain sensation and neurodegeneration.
Ophélie Molton +2 more
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The Journal of Physiology, Volume 603, Issue 18, Page 5053-5070, September 15, 2025.Abstract figure legend The role of lactate and hydrogen ions in evoking the metabolic component of the exercise pressor reflex was studied in rats with either a functional pygm gene (pygm+/+) or with a non‐functional “knocked out” pygm gene (pygm−/−). The pygm gene is responsible for producing the myophosphorylase enzyme which catalyses the breakdown ...
Guillaume P. Ducrocq +3 more
wiley +1 more source
4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors
International Journal of Molecular SciencesAcid-sensing ion channels (ASICs) play a key role in the perception and response to extracellular acidification changes. These proton-gated cation channels are critical for neuronal functions, like learning and memory, fear, mechanosensation and internal adjustments like synaptic plasticity.
Maksym Platonov +11 more
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Inhibition of ASIC1a Improves Behavioral Recovery after Stroke
eneuroStroke continues to be a leading cause of death and long-term disabilities worldwide, despite extensive research efforts. The failure of multiple clinical trials raises the need for continued study of brain injury mechanisms and novel therapeutic strategies for ischemic stroke. The contribution of acid-sensing ion channel 1a (ASIC1a) to neuronal injury
Ariel Armstrong +3 more
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The Effects of Synthetic ASIC1a Peptide on Glial Proliferation
The FASEB Journal, 2012 Increased activity of large conductance calcium and voltage‐activated potassium (BK) channels has been shown to accelerate glial proliferation. Our previous studies indicate that Acid Sensing Ion channels (ASICs) inhibit BK at physiological pH levels, and that this inhibition can be relieved at acidic pH. Both normal glia and glioma express BK and ASIC
Jennifer C. Guercio, Elena Petroff
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An inhibitory action of ASIC1a peptide on BK channels
The FASEB Journal, 2009 Acid Sensing Ion Channels contain a sequence that is identical to scorpion toxins blocking potassium channels, and this sequence is critical for ASICs' inhibition of large conductance calcium‐ and voltage‐activated potassium (BK) channels (Petroff et al., PNAS 2008, 118(4), 1571). In this
openaire +1 more source
Neuronal ASIC1A As a Cerebral pH Sensor [PDF]
Circulation Research, 2019 Ryan J, Stark +2 more
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