Results 91 to 100 of about 2,309 (187)

The Role of Neuro‐Immune Regulation in the Pathogenesis of Psoriasis

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory neurons in the initiation and progression of psoriatic ...
Xin Liu, Mingyu Yu, Pan Zou, Suwen Liu, Jian Jiang, Liyang Ge, Su Jiang, Jingyu Zhang, Xin Wang, Hongxiang Chen, Poorani Gurumallesh Prabu   +10 more
wiley   +1 more source

Gating‐associated conformational changes in the pore of ASIC1a

The FASEB Journal, 2010
Acid‐sensing ion channels (ASICs) are trimeric cation channels that undergo concerted activation and desensitization in response to extracellular acidification. Each subunit has two transmembrane domains (TMs) connected by a large extracellular region with intracellular N‐ and C‐ terminus.
Lindsey A Tolino, Sora Okumura, Marcelo D Carattino   +2 more
openaire   +1 more source

Delta opioid receptor regulation of ASIC1a-dependent neurotoxicity [PDF]

, 2015
Health Professions - Laboratory/Cellular (The Ohio State University Denman Undergraduate Research Forum)Acid-sensing ion channel 1a (ASIC1a) promotes neuronal death in pathological acidosis, however, little is known regarding ASIC1a-dependent ...
Schimmoeller, Ethan, Sherwood, Tom, Vick, Jonathan   +2 more
core  

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

PSD-95 inhibits ASIC1a/2a heteromeric channels.

, 2014
A, Representative pH 5-evoked currents in CHO cells coexpressing ASIC1a and ASIC2a, with either dsRed as a control or PSD-95 at 1∶10 cDNA ratios.
Mamta Gautam (327051), Christopher J. Benson (327052), Nobuyoshi Kusama (546426), Tomonori Hattori (546427), Anne Marie S. Harding (546425)   +4 more
core   +1 more source

Ecosystem services provided by spiders

Biological Reviews, Volume 100, Issue 6, Page 2217-2236, December 2025.
ABSTRACT Spiders, ubiquitous and abundant predators in terrestrial ecosystems, often are the subjects of an unjust negative perception. However, these remarkable creatures stand as unsung heroes within our ecosystems, contributing a multitude of ecosystem services critical to human well‐being.
Pedro Cardoso, Stano Pekár, Klaus Birkhofer, Angela Chuang, Caroline Sayuri Fukushima, Eileen A. Hebets, Yann Henaut, Thomas Hesselberg, Jagoba Malumbres‐Olarte, Ondřej Michálek, Radek Michalko, Catherine Scott, Jonas Wolff, Stefano Mammola   +13 more
wiley   +1 more source

Loss of ASIC1a had no impact on striatal catecholamines after subacute MPTP treatment.

, 2016
Striatal concentration of dopamine (A) and the metabolite ratio (B) were determined by HPLC. Results were analyzed by two-way ANOVA followed by Bonferroni post hoc tests; ns = non significant. Number of animals: NaCl ASIC1a+/+: n = 3; NaCl ASIC1a-/-: n =
Arno Reich (163313), Silke Imgrund (3335688), Daniel Komnig (3335694), Stefan Gründer (652717), Björn H. Falkenburger (3335691)   +4 more
core   +1 more source

Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons

Frontiers in Cellular Neuroscience, 2020
Acid-sensing ion channels (ASICs) are H+-activated neuronal Na+ channels. They are involved in fear behavior, learning, neurodegeneration after ischemic stroke and in pain sensation.
Omar Alijevic, Olivier Bignucolo, Olivier Bignucolo, Echrak Hichri, Zhong Peng, Jan P. Kucera, Stephan Kellenberger   +6 more
doaj   +1 more source

Dysregulation of Different Modes of Programmed Cell Death in Rheumatoid Arthritis Fibroblast‐Like Synoviocyte

International Journal of Rheumatic Diseases, Volume 28, Issue 10, October 2025.
ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic synovitis and skeletal joint deformities, often accompanied by systemic symptoms. Over the past few decades, various susceptibility factors for RA have been revealed, and numerous therapeutic drugs have been developed, including analgesics, glucocorticoids ...
Xiaorong Zhi, Hong Zhu, Xiaoyan Sun, Zhaoxia Wang, Lin Wang, Guanhua Song   +5 more
wiley   +1 more source

ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion

Nature Communications, 2016
The acid-sensing ion channel, ASIC1a, is known to play a role in synaptic transmission and plasticity. Here, the authors demonstrate a role for ASIC1a in regulating plasticity in the insular cortex and find that extinction of conditioned taste aversion ...
Wei-Guang Li, Ming-Gang Liu, Shining Deng, Yan-Mei Liu, Lin Shang, Jing Ding, Tsan-Ting Hsu, Qin Jiang, Ying Li, Fei Li, Michael Xi Zhu, Tian-Le Xu   +11 more
doaj   +1 more source