Results 111 to 120 of about 2,309 (187)
, 2014 A, Example traces of a fast-inactivating transient current and a sustained current of ASIC1a activated by pH 3.5. GABA (100 μM) attenuated a fast-inactivating transient current and enhanced the sustained current of ASIC1a in HEK293 cells co-transfected ...
Zhen Lei (480837) +6 more
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, 2013 (A & B) Representative blots showing the effect of a reduced culture temperature on ASIC1a glycosylation. CHO cells were transfected with wild-type ASIC1a, W287G or Y71G mutant.
Xiang-ming Zha (340963) +5 more
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The Role of Acid-Sensing Ion Channel 1A (ASIC1A) in the Behavioral and Synaptic Effects of Oxycodone and Other Opioids. [PDF]
Int J Mol SciOpioid-seeking behaviors depend on glutamatergic plasticity in the nucleus accumbens core (NAcc). Here we investigated whether the behavioral and synaptic effects of opioids are influenced by acid-sensing ion channel 1A (ASIC1A). We tested the effects of
Fuller MJ +9 more
europepmc +2 more sources
, 2020 Acid-sensing ion channels (ASICs) are proton-gated cation channels found in peripheral and central nervous system neurons. The ASIC1a subtype, which has high Ca 2ϩ permeability, is activated by ischemia-induced acidosis and contributes to the neuronal ...
Y H +13 more
core
Mutating Tyr71 and Trp287 reduces ASIC1a surface expression.
, 2013 (A) The effect of N- and C-terminal tags on surface expression of ASIC1a. CHO cells were transfected with untagged, N-terminal or C-terminal HA- or Flag-tagged ASIC1a as indicated.
Xiang-ming Zha (340963) +5 more
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Comparison of CFRs from predictions for ASIC1a and literature.
, 2015 Residues listed are those implicated in the literature as pH-sensing for ASIC1a (see text), followed by whether these amino acids are also highlighted in the three calculations (indicated by x).
Ivan Sazanavets (730618) +1 more
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Analysis of ASIC1a function and signalling
, 2019 The deposited files include the dataset of the experimental part of the submitted manuscript on the function of ASIC1a, as well as Matlab scripts of kinetic models that are part of the ...
Bignucolo, Olivier +5 more
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An inhibitory action of ASIC1a peptide on BK channels
The FASEB Journal, 2009 Acid Sensing Ion Channels contain a sequence that is identical to scorpion toxins blocking potassium channels, and this sequence is critical for ASICs' inhibition of large conductance calcium‐ and voltage‐activated potassium (BK) channels (Petroff et al., PNAS 2008, 118(4), 1571). In this
openaire +1 more source
, 2011 Ischemic brain injury is a major problem associated with stroke. It has been increasingly recognized that acid-sensing ion channels (ASICs) contribute significantly to ischemic neuronal damage, but the underlying mechanism has remained elusive.
Yu Huang +11 more
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Activation of GABAA receptors reversibly inhibits ASIC1a currents.
, 2014 A, ASIC1a were activated by pH 6.0 solution repetitively in HEK293 cells co-transfected with GABAA receptor subunits (α1 and β2) and ASIC1a. GABA (100 μM) reversibly attenuated ASIC1a currents. Red arrow indicates the current activated by GABA.
Zhen Lei (480837) +6 more
core +1 more source