Results 131 to 140 of about 1,823 (155)
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Determinants of action of hydrophobic amines on ASIC1a and ASIC2a
European Journal of Pharmacology, 2016Acid-sensing ion channels (ASICs) are involved in numerous physiological and pathological processes in the central nervous system. Development of pharmacological tools capable to inhibit or potentiate these channels is important for our knowledge about roles of ASICs in the neuronal network and can be promising for treatment of some disorders. Recently
Elina I, Nagaeva +5 more
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Upregulation of ASIC1a channels in an in vitro model of Fabry disease
Neurochemistry International, 2020Neuropathic pain is one of the key features of the classical phenotype of Fabry disease (FD). Acid sensing ion channels (ASICs) are H+-gated cation channels, which belong to the epithelial sodium channel/DeGenerin superfamily, sensitive to the diuretic drug Amiloride. Molecular cloning has identified several distinct ASIC subunits.
Carina Weissmann, , Osvaldo Uchitel
exaly +4 more sources
Role of ASIC1a in Normal and Pathological Synaptic Plasticity
2020Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are broadly distributed in the mammalian nervous system where they play important roles in a variety of physiological processes, including neurotransmission and memory-related behaviors.
Mango, Dalila, Nisticò, Robert
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Photomodulation of the
AbstractAcid‐sensing ion channels (ASICs) are important players in detecting extracellular acidification throughout the brain and body. ASICs have large extracellular domains containing two regions replete with acidic residues: the acidic pocket, and the palm domain.
Matthew L. Rook +4 more
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ASIC1a polymorphism is associated with temporal lobe epilepsy
Epilepsy Research, 2011Recent in vitro and in vivo data show that acid-sensing ion channel 1a (ASIC1a) activation enhances neuronal excitability in the hippocampus and neocortex, indicating that ASIC1a might play a role in the generation and maintenance of epileptic seizures. The aim of this study was to investigate association of the ASIC1a gene with temporal lobe epilepsy (
Rui-Juan, Lv +8 more
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Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry [PDF]
Cell Calcium, 2009 Acid Sensing Ion Channels (ASICs) are a family of proton-gated cation channels that play a role in the sensation of noxious stimuli. Of these, ASIC1a is the only family member that is reported to be permeable to Ca(2+), although the absolute magnitude of the Ca(2+) current is unclear.
Terrance Egan, Damien S K Samways
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The Journal of Pharmacology and Experimental Therapeutics, 2008
Acid-sensing ion channels (ASICs) are proton-gated cation channels found in peripheral and central nervous system neurons. The ASIC1a subtype, which has high Ca2+ permeability, is activated by ischemia-induced acidosis and contributes to the neuronal loss that accompanies ischemic stroke.
Yelenis, Herrera +6 more
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Acid-sensing ion channels (ASICs) are proton-gated cation channels found in peripheral and central nervous system neurons. The ASIC1a subtype, which has high Ca2+ permeability, is activated by ischemia-induced acidosis and contributes to the neuronal loss that accompanies ischemic stroke.
Yelenis, Herrera +6 more
openaire +2 more sources
ASIC1a promotes synovial invasion of rheumatoid arthritis via Ca2+/Rac1 pathway
International Immunopharmacology, 2020Feihu Chen, Jingjing Tao, Cong Wang
exaly