Results 121 to 130 of about 1,823 (155)

Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche. [PDF]

J Clin Invest
Gu H, Weng L, Chen C, Hao X, Tao R, Qi X, Lai X, Liu L, Zhang T, Jiang Y, Wang J, Li WG, Yu Z, Xie L, Zhang Y, He X, Yu Y, Yang Y, Wu D, Zhao Y, Xu TL, Chen GQ, Zheng J.   +22 more
europepmc   +1 more source

A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia. [PDF]

J Cereb Blood Flow Metab
Farkas E, Rose CR.
europepmc   +1 more source

Unlocking glioma vulnerabilities: targeting regulated cell death pathways for innovative therapies. [PDF]

Cell Death Discov
Guo J, Zong L, Huang Y, Liu X, Hu Y, Liu Y.   +5 more
europepmc   +1 more source

Deciphering the Role of Functional Ion Channels in Cancer Stem Cells (CSCs) and Their Therapeutic Implications. [PDF]

Int J Mol Sci
Samanta K, Reddy GSVSR, Sharma NK, Kar P.   +3 more
europepmc   +1 more source

Dual roles of lactate and lactylation modification in the nervous system: neuroprotection and neuroinjury. [PDF]

Front Aging Neurosci
Ran T, Shen Y, Peng D, Tang L, Pan Z, Zeng X, Liu H.   +6 more
europepmc   +1 more source

The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target

Current Neuropharmacology, 2021
Background: Epilepsy represents one of the most common brain diseases among humans. Tissue acidosis is a common phenomenon in epileptogenic foci. Moreover, its role in epileptogenesis remains unclear. Acid-sensing ion channel-1a (ASIC1a) represents a potential way to assess new therapies.
Cheng, Yu, Zhang, Wuqiong, Li, Yue, Jiang, Ting, Mamat, Buhajar, Zhang, Yunhai, Wang, Famin, Meng, Hongmei   +7 more
exaly   +3 more sources

ASIC1A in neurons is critical for fear‐related behaviors [PDF]

Genes, Brain and Behavior, 2017
Acid‐sensing ion channels (ASICs) have been implicated in fear‐, addiction‐ and depression‐related behaviors in mice. While these effects have been attributed to ASIC1A in neurons, it has been reported that ASICs may also function in nonneuronal cells. To determine if ASIC1A in neurons is indeed required, we generated neuron‐specific knockout (KO) mice
John Wemmie, Rebecca Taugher-Hebl
exaly   +3 more sources

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Redistribution of ASIC1a channels triggered by IL-6: Potential role of ASIC1a in neuroinflammation

Biochimica Et Biophysica Acta - Molecular Basis of Disease
Cytokines, particularly IL-6, play a crucial role in modulating immune responses in the central nervous system (CNS). Elevated IL-6 levels have been observed in neuroinflammatory conditions, as well as in the sera and brains of patients with neurodegenerative diseases such as Parkinson's, Huntington's, Multiple Sclerosis, and Alzheimer's. Additionally,
Carina Weissmann, Osvaldo Uchitel
exaly   +3 more sources

Potentiation and Block of ASIC1a by Memantine

Cellular and Molecular Neurobiology, 2017
Acid-sensing ion channels (ASICs) are modulated by various classes of ligands, including the recently described hydrophobic monoamines, which inhibit and potentiate ASICs in a subunit-specific manner. In particular, memantine inhibits ASIC1a and potentiates ASIC2a homomers.
Vasiliy Y, Shteinikov, Tatiana B, Tikhonova, Vyacheslav S, Korkosh, Denis B, Tikhonov   +3 more
openaire   +2 more sources

Kaempferol attenuates carbon tetrachloride (CCl4)-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS

Phytomedicine, 2023
Kaempferol is a flavonoid derived from the herb, Kaempferia galanga L., in addition to exhibiting a wide range of pharmacological properties, kaempferol is also an anti-inflammatory, anti-lipid metabolizing, and anti-oxidative stress agent. The underlying molecular mechanisms of its effects on vascular endothelial growth factor (VEGF) secretion and ...
Rui Cao, Chun Cao, Xiaojie Hu, Kang Du, Jingrong Zhang, Mengxue Li, Bowen Li, Huimin Lin, Anqi Zhang, Yangyang Li, Li Wu, Yan Huang   +11 more
openaire   +2 more sources