Results 121 to 130 of about 2,309 (187)
Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia
, 2007 Acid-sensing ion channels (ASICs), newly discovered members of epithelial Na+ channels/degenirin superfamily, are widely distributed throughout the mammalian peripheral and central nervous system and have been implicated in many physiological and ...
Simon RP, PIGNATARO, GIUSEPPE, Xiong ZG
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, 2018 Increases in pulmonary arterial smooth muscle cell (PASMC) intracellular Ca2+ levels and enhanced RhoA/Rho kinase-dependent Ca2+ sensitization are key determinants of PASMC contraction, migration, and proliferation accompanying the development of ...
Nikki L. Jernigan +2 more
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Neuronal ASIC1A As a Cerebral pH Sensor [PDF]
Circulation Research, 2019 Ryan J, Stark +2 more
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ASIC1a is present in vagal ganglia and expression in the airway is non-specific or negligible.
, 2016 A) Images of wild-type (WT) and ASIC1a-/- mouse vagal ganglia. ASIC1a immunostaining is in green, and DIC indicates differential interference contrast images. Scale bar in left and middle panels is 60 μm; scale bar in the right panel is 40 μm. B) Western
Leah R. Reznikov (674878) +9 more
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ASIC1a contributes to neuroprotection elicited by ischemic preconditioning and postconditioning.
International journal of physiology, pathophysiology and pharmacology, 2011 Acid-sensing ion channels, ASICs, are proton-gated cation channels widely expressed in peripheral sensory neurons and in neurons of the central nervous system that play an important role in a variety of physiological and pathological processes. To further confirm the role played by ASIC1a in cerebral ischemia, here we examined the involvement of this ...
PIGNATARO, GIUSEPPE +5 more
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Voltage-dependent inhibition of ASIC1a by diminazene.
, 2018 (A) Representative ramp tracings from an oocyte expressing ASIC1a before and after diminazene. Ramps from +60 to -140 mV with a duration of 500 msec were generated in the absence and presence of diminazene (1 nM and 1 μM).
Marcelo D. Carattino (5244173) +2 more
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A Selectivity Filter at the Lower End of ASIC1a [PDF]
Biophysical Journal, 2017 Timothy Lynagh +7 more
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Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction
, 2016 Acid sensing ion channels 1a (ASIC1a) are of crucial importance in numerous physiological and pathological processes in the brain. Here we demonstrate that novel 2-oxo-2H-chromene-3-carboxamidine derivative 5b, designed with molecular modeling approach ...
Oleksandr Ievglevskyi (1671187) +9 more
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Inhibitor-Induced Conformational Changes in ASIC1A [PDF]
Biophysical Journal, 2018 Lund, Camilla +3 more
openaire +2 more sources
, 2009 Acid-sensing ion channels (ASIC) are a class of ligand gated plasma membrane ion channels that are activated by low extracellular pH. During ischemia, ASIC1a are activated and contribute to the demise of neurons.
Herrera, Yelenis
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