Results 101 to 110 of about 2,309 (187)

Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties

Toxins, 2019
Acid-sensing ion channels (ASICs), which are present in almost all types of neurons, play an important role in physiological and pathological processes. The ASIC1a subtype is the most sensitive channel to the medium’s acidification, and it plays an
Dmitry I. Osmakov, Sergey G. Koshelev, Victor A. Palikov, Yulia A. Palikova, Elvira R. Shaykhutdinova, Igor A. Dyachenko, Yaroslav A. Andreev, Sergey A. Kozlov   +7 more
doaj   +1 more source

Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions

The Journal of Physiology, Volume 603, Issue 18, Page 5053-5070, September 15, 2025.
Abstract figure legend The role of lactate and hydrogen ions in evoking the metabolic component of the exercise pressor reflex was studied in rats with either a functional pygm gene (pygm+/+) or with a non‐functional “knocked out” pygm gene (pygm−/−). The pygm gene is responsible for producing the myophosphorylase enzyme which catalyses the breakdown ...
Guillaume P. Ducrocq, Laura Anselmi, Victor Ruiz‐Velasco, Marc P. Kaufman   +3 more
wiley   +1 more source

Identification of the modulatory Ca2+-binding sites of acid-sensing ion channel 1a

Open Biology
Acid-sensing ion channels (ASICs) are neuronal Na+-permeable ion channels activated by extracellular acidification. ASICs are involved in learning, fear sensing, pain sensation and neurodegeneration.
Ophélie Molton, Olivier Bignucolo, Stephan Kellenberger   +2 more
doaj   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

MedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li, Xing Li, Jieqiong Liu, Rao Sun, Yingze Ye, Hongbing Xiang, Fang Luo, Shiyong Li, Ailin Luo   +8 more
wiley   +1 more source

Neural Stem Cell‐Derived Extracellular Vesicles for Advanced Neural Repair

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Neurodegenerative and neuroinflammatory diseases, such as Alzheimer's and multiple sclerosis (MS), are characterized by inflammation, nerve cell damage, and a limited capacity for natural repair, which worsens with aging. While neural stem cells (NSCs) show promise for brain repair, their clinical use is limited by safety and delivery challenges.
Eduardo H. Moretti, Ally L. Y. Lin, Luca Peruzzotti‐Jametti, Stefano Pluchino, Sabah Mozafari   +4 more
wiley   +1 more source

Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a

Frontiers in Cell and Developmental Biology, 2020
Acid-sensing ion channels (ASICs) are members of the degenerin/epithelial sodium channel superfamily. They are extracellular pH sensors that are activated by protons.
Yayun Xu, Yayun Xu, Yayun Xu, Feihu Chen, Feihu Chen, Feihu Chen   +5 more
doaj   +1 more source

4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors

International Journal of Molecular Sciences
Acid-sensing ion channels (ASICs) play a key role in the perception and response to extracellular acidification changes. These proton-gated cation channels are critical for neuronal functions, like learning and memory, fear, mechanosensation and internal adjustments like synaptic plasticity.
Maksym Platonov, Oleksandr Maximyuk, Alexey Rayevsky, Vasyl Hurmach, Olena Iegorova, Vasyl Naumchyk, Elijah Bulgakov, Andrii Cherninskyi, Danil Ozheredov, Serhiy V. Ryabukhin, Oleg Krishtal, Dmytro M. Volochnyuk   +11 more
openaire   +2 more sources

Inhibition of ASIC1a Improves Behavioral Recovery after Stroke

eneuro
Stroke continues to be a leading cause of death and long-term disabilities worldwide, despite extensive research efforts. The failure of multiple clinical trials raises the need for continued study of brain injury mechanisms and novel therapeutic strategies for ischemic stroke. The contribution of acid-sensing ion channel 1a (ASIC1a) to neuronal injury
Ariel Armstrong, Tao Yang, Tiandong Leng, Zhi-Gang Xiong   +3 more
openaire   +2 more sources

Lowering the culture temperature increases ASIC1a surface expression.

, 2013
Representative Western blot (A) and quantification (B) showing the effect of 24 hrs of 27°C on surface expression of wild-type and mutant ASIC1a. ASIC1a (red channel) and tubulin (green channel) were blotted and detected on the same blot as described in ...
Xiang-ming Zha (340963), Xiang-Ping Chu (340962), Lan Jing (340960), Yu-Qing Jiang (340961), Qian Jiang (216582), Bin Wang (30851)   +5 more
core   +1 more source

The Effects of Synthetic ASIC1a Peptide on Glial Proliferation

The FASEB Journal, 2012
Increased activity of large conductance calcium and voltage‐activated potassium (BK) channels has been shown to accelerate glial proliferation. Our previous studies indicate that Acid Sensing Ion channels (ASICs) inhibit BK at physiological pH levels, and that this inhibition can be relieved at acidic pH. Both normal glia and glioma express BK and ASIC
Jennifer C. Guercio, Elena Petroff
openaire   +1 more source