Results 71 to 80 of about 3,624,683 (287)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Chemical trends at lakes and streams in the UK Acid Waters Monitoring Network, 1988-2000: evidence for recent recovery at a national scale [PDF]
, 2001 A detailed trend analysis of 12 years of data (1988-2000) for 22 surface waters in acid-sensitive regions of the United Kingdom, in which individual site data have been combined to identify national-scale trends, has shown strong common patterns of ...
Monteith, D. T. +3 more
core +1 more source
The effects of acid nitrogen and acid sulphur deposition on CH4 oxidation in a forest soil: a laboratory study [PDF]
, 2001 Sieved soil and soil core experiments were performed to determine the potential sensitivity of forest soil CH4 oxidation to oxidised N, reduced N and oxidised S atmospheric deposition.
H.M Lappin-Scott +11 more
core +1 more source
Atmospheric Deposition of Nitrogen and Sulphur Compounds in the Czech Republic
The Scientific World Journal, 2001 Estimates of dry and wet deposition of nitrogen and sulphur compounds in the Czech Republic for the years 1994 and 1998 are presented. Deposition has been estimated from monitored and modeled concentrations in the atmosphere and in precipitation, where ...
Milos Zapletal
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Ecology and EvolutionArtificial sulfur (S) and nitrogen (N) addition experiments often fail to accurately simulate acid deposition in terms of type, composition, intensity, frequency, and duration, potentially leading to biased estimates of deposition impact on plant ...
Chunhuan Li +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source