Results 241 to 250 of about 4,277,838 (300)

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Cooperative Host-Guest Complexation in Densely Assembled Host Structures on Surfaces Revealed at the Single-Molecular Level. [PDF]

J Am Chem Soc
Asakawa H, Hatano H, Fa S, Sumikama T, Shibata M, Takashima S, Ogasawara M, Ohta A, Yamagishi TA, Ogoshi T.   +9 more
europepmc   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Unravelling the Interaction Mechanism Between Oryzanol and Human Serum Albumin: An Integrated Approach Using Multispectral Analysis and Molecular Simulations. [PDF]

Foods
Zhang C, Zhu S, Duan S, Meng K, Guo M, Wei L, Shi J, Liang F.   +7 more
europepmc   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

<i>ortho</i>-Substituents govern aryl aldehyde reactivity: toward lysine-targeted, tunable inhibitors of glucose-6-phosphate dehydrogenase. [PDF]

RSC Chem Biol
Rowland BE, Roy KD, Alkaş A, Barsoum M, Kuot T, Fuller JC, Naudet AJ, Ospanow E, Jakeman DL.   +8 more
europepmc   +1 more source

Phase-Engineered Ru-MoC Heterointerfaces for Efficient Alkaline Hydrogen Evolution by Boosting Interfacial Water Dissociation. [PDF]

Adv Mater
Bai X, Feng B, Huang J, Tian J, Jiang Y, Yu Y, Wang X, Yang L, Huang H, Hu Z, Wu Q.   +10 more
europepmc   +1 more source

Digitized dataset of aqueous acid dissociation constants. [PDF]

RSC Adv
Zheng JW, Lafontant-Joseph O, Green WH.
europepmc   +1 more source

VEGFR2 dimerization kinetics on the cell surface determined by microscopy and mathematical modeling. [PDF]

Biophys J
Guerrero J, Malik Z, Bilal F, Jana S, Dasgupta A, Jaqaman K.   +5 more
europepmc   +1 more source

Structural Characterization of Calcium-Dependent Calmodulin-Calmidazolium Binding Using Capillary Vibrating Sharp-Edge Spray Ionization-Based Native Mass Spectrometry and In-Droplet Hydrogen-Deuterium Exchange Mass Spectrometry. [PDF]

ACS Omega
Ahmed S, Woehrling A, Li P, Valentine SJ, Courtney KC.   +4 more
europepmc   +1 more source