Results 251 to 260 of about 445,203 (313)

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Ultrafast, High‐Capacity Uranium Harvesting From Seawater via a Hierarchically Porous Polymer Electrode

Advanced Science, EarlyView.
A hierarchically porous AOPIM‐CNT electrode enables uranium harvesting from seawater via adsorption‐promoted electrodeposition. Rapid diffusion and selective adsorption are coupled with electrochemical crystallization and spontaneous detachment, creating a self‐refreshing process that sustains high‐capacity, continuous extraction from ultradilute ...
Zejun Song, Zhenggong Wang, Lele Guo, Zhining Wang, Keming Wan, Ting Zhang, Wangxi Fang, Jian Jin   +7 more
wiley   +1 more source

Precision Lignocellulosic Biorefinery: Process Regulation From Corn Stover to Products

Advanced Science, EarlyView.
This study presents a precision biorefinery framework that transforms corn stover into high‐value bioproducts through whole‐process regulation. Mechanical fractionation separates feedstock into parenchyma‐rich short fibers and vascular‐bundle‐dominant long fibers.
Xue‐Cheng Lin, Lan Wang, Tai‐Ran Pang, Ming‐Yuan Yin, Hong‐Zhang Chen   +4 more
wiley   +1 more source

Electrostatic Self‐Assembly Induced Nest‐Like MXene Networks on Fabric for Ultra‐Broadband Flexible Absorption

Advanced Science, EarlyView.
In this study, an electrostatically self‐assembled WPU‐MXene@FC flexible fabric constructs a “nest‐like” structure on fibers, building construct MXene multiple loss paths, achieving ultra‐wideband absorption of 25.3–1200 GHz in a thickness of 1.8 mm, while also exhibiting superhydrophobicity, acid and alkali resistance, and bending resistance ...
Min Luo, Zihao Chen, Haotian Li, Kexun Li, Wei Wang, Weishi Jiao, Donghong Wang, Qiye Wen   +7 more
wiley   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Simulation of dilute acid hydrolysis of lignocellulosic materials: wheat straw

, 1998
Sidiras Dimitris, K
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The acid hydrolysis of glycosides

Carbohydrate Research, 1967
Abstract Isopropyl and 2-chloroethyl 3-O-methyl-β- d -glucopyranosiduronic acids, but not the corresponding β- d -glucopyranosides, are hydrolyzed in acid solution at a rate higher than that for the unmethylated compounds. The hydrolysis of 6-O-methyl-β- d -glucopyranosides is independent of the polarity of the aglycon. Several 5-C-substituted methyl
M.D. Saunders, T.E. Timell
openaire   +1 more source

Acid Hydrolysis of Sulphapyridines

Nature, 1946
SULPHAPYRIDINE (M and B 693) is readily hydrolysed by dilute mineral acids1. Many isomerides of sulphapyridine have been made and it has been found that the three isomeric derivatives from 3-aminopyridine (3-(o-, m- and p-aminobenzenesulphonamido)pyri-dine) are stable to hot mineral acids.
openaire   +2 more sources