Results 151 to 160 of about 458,181 (213)

Mitochondrial Dysfunction in Propionic Acidemia: A Case-Report and Review of the Literature. [PDF]

JIMD Rep
Walther BK, Murray BM, Pandiyan P, Ray R, Yeoh L, Kritzer A.   +5 more
europepmc   +1 more source

Tuned Oxidation Potential of Continuous Defective Photocatalyst for Selective Biomass Conversion

Advanced Science, EarlyView.
This work develops a wavelength‐controlled photocatalytic strategy that utilizes defect‐state excitation to modulate oxidative capability for biomass selective conversion. By tuning the photooxidation potential to match substrate reactivity, the system suppresses overoxidation and enables the selective formation of value‐added products, providing a ...
Longfei Hong, Huiyan Zhang, Liangdong Hu, Xiang Gao, Lianhua Xu, Qingyu Liu, Rui Xiao, Sheng Chu   +7 more
wiley   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Sustainable leaching of mixed LIB waste cathode employing a deep eutectic solvent composed of l-proline and lactic acid. [PDF]

RSC Adv
Panda P, Mishra S.
europepmc   +1 more source

Improving microbial safety of poultry products by combined steam and lactic acid decontamination treatments [PDF]

, 2008
Collignan, Antoine, Kondjoyan, Alain, Lecompte, Jean-Yves, Portaguen, Stéphane, Sarter, Samira   +4 more
core  

Ultrasound‐Responsive Engineered Bacteria for Targeted Cancer Therapy: Strategies, Mechanisms, and Applications

Advanced Science, EarlyView.
This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang, Wenjing Xu, Yafang Lu, Huaibin Yu, Zhengbao Zha, Xijun Zhang   +5 more
wiley   +1 more source

Novel green solvent-in situ ultrasound synergistic extraction of phenolic acids from Lonicera japonica thunb. [PDF]

Ultrason Sonochem
Liu C, Zhao Q, Ma X, He S, Zou X, Gong F, Liu Y, Lei J, Xiong Z, Liu J.   +9 more
europepmc   +1 more source

Molecularly Engineered Phenoxazinone‐Skeleton Cascade‐Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis‐Mediated Parkinson's Disease

Advanced Science, EarlyView.
A series of Fe2+/viscosity cascade‐activated NIR fluorescence probes (NP1–5) are synthesized, and NP3 is selected for its optimal properties. To verify application of NP3 in ferroptosis intervention in PD, PQR NPs, is constructed by NP3 and quercetin self‐assembling.
Lixia Guo, Tao Liu, Hongfei Wang, Qi Gao, Zhaobo Yang, Zumeng Wang, Chenlong Li, Yubing Kang, Kahleong Lim, Wen Liu, Li Lu, Chengwu Zhang   +11 more
wiley   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source