Results 271 to 280 of about 5,647,881 (348)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Lactic acid fermentation using Rhizopus spp.: current insights and future prospects. [PDF]

Bioresour Bioprocess
Akter MM, Jim MA, Gilroyed B.
europepmc   +1 more source

Giant Isotope Effect in Metal–Organic Frameworks Boosts Unprecedented Photo‐ and Radio‐Luminescence Enhancement

Advanced Science, EarlyView.
Deuterated MOFs in this work exhibited unprecedented giant luminescence isotope effect via O─H oscillator suppression, achieving maximal solid‐state materials emission enhancement. This yields significantly improved X‐ray detection sensitivity and imaging resolution, marking the first integration of MOFs with isotopic luminescence and opening new ...
Junhao Lu, Dan Zhou, Xianhuan Hao, Hao Lu, Zhongyuan Zhang, Yuhuan Jia, Sen Mei, Ye Huang, Songbai Tang, Zhiyong Peng, Lanhua Chen, Mengjia Yuan, Lixi Chen, Shuaihua Wang, Meiling Feng, Yanlong Wang, Shuao Wang   +16 more
wiley   +1 more source

Effect of Conventional and Ultrasound-Assisted Extraction Conditions on the Physicochemical Properties, Phytochemical Content, Antioxidant Activity and Functional Properties of Alfalfa Protein Concentrates. [PDF]

Foods
Gurev A, Bulgaru V, Ciugureanu I, Netreba N, Dragancea V, Dianu I, Sandu I, Mazur M, Mitina T, Bandarenco N, Ghendov-Mosanu A.   +10 more
europepmc   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Metabolomic analysis of microbial effects on quality and metabolite conversion in rapidly fermented salt-free shrimp by-product sauce. [PDF]

Food Chem X
Luo JW, Li ZB, Xiao S, Chen X, Yang XY, Wang JH.   +5 more
europepmc   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Deep Eutectic Solvents as a Sustainable Approach for Silica Recovery from Rice Husk. [PDF]

Molecules
Faria-Júnior CS, Silva LDS, Cunha ALC, Buarque FS, Ribeiro BD.   +4 more
europepmc   +1 more source

A Case of Fixation Using Poly-L-Lactic Acid Pins for Chronic Juvenile Massive Osteochondritis Dissecans of the Knee. [PDF]

J Orthop Case Rep
Ichikawa K, Maeyama A, Ishimatsu T, Matsunaga T, Nakayama S, Yamamoto T.   +5 more
europepmc   +1 more source