Results 131 to 140 of about 802,100 (213)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Bacteriological Assessment of Different Root Canal Irrigants

open access: yesJournal of Baghdad College of Dentistry
Aim of the study: To evaluate the antibacterial action of different root canal irrigants. Materials and method: By the use of the zone of inhibition method, sodium hypochlorite (2.5% and 5%), acetic acid (2%), sodium chloride solutions (5 and 10%), and ...
Hussain F Al-Huwaizi
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Complex Protection of Some Steels in Sulfuric Acid Solutions by 1,2,4-Triazole Derivatives. [PDF]

open access: yesMaterials (Basel)
Avdeev YG   +4 more
europepmc   +1 more source

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