Results 101 to 110 of about 10,325 (203)

Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice [PDF]

The American Journal of Pathology, 2011
Hyperhomocysteinemia (hHcys) enhances ceramide production, leading to the activation of NADPH oxidase and consequent glomerular oxidative stress and sclerosis. The present study was performed to determine whether acid sphingomyelinase (Asm), a ceramide-producing enzyme, is implicated in the development of hHcys-induced glomerular oxidative stress and ...
Krishna M, Boini, Min, Xia, Caixia, Li, Chun, Zhang, Lori P, Payne, Justine M, Abais, Justin L, Poklis, Philip B, Hylemon, Pin-Lan, Li   +8 more
openaire   +2 more sources

The epidthelial sodium channel ENaC and its regulators in the epidermal permeability barrier function [PDF]

, 2010
The highly amiloride-sensitive epithelial sodium channel ENaC is well known to be involved in controlling whole body sodium homeostasis and lung liquid clearance. ENaC expression has also been detected in the skin of amphibians and mammals.
Charles, R-P., Frateschi, S., Hummler, E.   +2 more
core   +1 more source

Inhibition of PLA2G15 Alleviates Palmitic Acid‐Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 2, June 2026.
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan, Jiang Jiang, Shuangshuang Tu, Chuanfu Li, Yijun Dong, Yongjin Li, Wenzhi Zhang, Xi Chen   +7 more
wiley   +1 more source

Favorable clinical response to olipudase alfa in a patient with two variants of uncertain significance in SMPD1: a case report

Egyptian Journal of Medical Human Genetics
Background Acid sphingomyelinase deficiency (ASMD), also known as Niemann–Pick disease, is a rare lysosomal storage disorder caused by biallelic pathogenic variants in the Sphingomyelin phosphodiesterase 1 (SMPD1) gene, leading to the deficient activity ...
Luz María Sánchez-Sánchez, Jorge Álvarez-Longoria, Beatriz De la Fuente-Cortez, Valentina Martínez-Montoya, Ekaterina Sánchez-Romero   +4 more
doaj   +1 more source

Les sphingolipides : vecteurs d’agents pathogènes et cause de maladies génétiques [PDF]

, 2006
Les sphingolipides (SPL) sont des molécules ubiquitaires indispensables au maintien et au développement des organismes vivants. Ils ne sont pas répartis uniformément le long de la membrane mais regroupés sous forme de microdomaines lipidiques appelés ...
Fasano, Caroline, Hiol, Abel, Miolan, Jean-Pierre, Niel, Jean-Pierre   +3 more
core   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Tetanus toxin Hc fragment induces the formation of ceramide platforms and protects neuronal cells against oxidative stress [PDF]

, 2013
Tetanus toxin (TeTx) is the protein, synthesized by the anaerobic bacteria Clostridium tetani, which causes tetanus disease. TeTx gains entry into target cells by means of its interaction with lipid rafts, which are membrane domains enriched in ...
A Gómez-Muñoz, A Rummel, Ana Candalija, Arturo Ortega, BA Tsui-Pierchala, BX Wu, C Gil, C Gil, C Gil, C Gil, C Montecucco, Carles Gil, CR Hauck, CR Hauck, D Samet, E Albi, E Gassert, EI Posse de Chaves, FL Yeh, G Lalli, G Schiavo, GS Baron, H Grassmé, H Grassmé, I Chaïb-Oukadour, I Chaïb-Oukadour, J Herreros, J Riethmüller, JK Bentley, JL Halpern, JM Holopainen, JM Toivonen, José Aguilera, K Deinhardt, K Jiang, K Schutze, K Trajkovic, L Abrami, L Mendieta, L Peng, LJ Ira, Johnston, LJ Pike, LK Koriazova, LL Simpson, M Bhuiyan, M Dong, M Dong, M Moreno-Igoa, MF Hanzal-Bayer, Michel R. Popoff, MP Veiga, O Dolly J, P Munro, PP Ruvolo, Roger Cubí, S Dreschers, S Falcone, S Grösch, S Karahatay, SC Murphy, SML Tse, T Numakawa, T Rogasevskaia, Y Chai, YH Zeidan, YPM van der Meer-Janssen   +65 more
core   +6 more sources

Study of Adult and Pediatric Spanish Patients with Cryptogenic Splenomegaly and Splenectomy

Diseases
Introduction: The differential diagnosis of splenomegaly is a complex process that encompasses a wide variety of diseases. Moreover, it is not always standardized and lacks a definitive consensus on which tests should be performed and in what order ...
Marta Morado Arias, Jesús Villarrubia Espinosa, Isidro Vitoria Miñana, Enrique Calderón Sandubete, Víctor Quintero, Miguel Ángel Torralba-Cabeza   +5 more
doaj   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Hypoxia and lipid signaling [PDF]

, 2017
Sufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to detect and ...
Huwiler, Andrea, Pfeilschifter, Josef
core